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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Enabling point-of-care molecular diagnostics by developing an adaptive PCR instrument and on-demand kit reagents

    SBC: BIOVENTURES, INC            Topic: 172

    Because of its high sensitivitypolymerase chain reactionPCRis the gold standard for the diagnosis of many infectious diseasesbut generally only implemented in well equipped laboratoriesOne of the major roadblocks for expanding PCR to point of care markets is the lack of simplerobustsingle tube PCR designs which preserve its laboratory based high sensitivity and specificityIn this Fast Track STTR a ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Development of an Open Speech Signal Processing Platform

    SBC: Flat Earth, Inc.            Topic: NIDCD

    This proposal will create an open speech signal processing platform. The open computational framework will be used for developing algorithms that will help accelerate acoustic and hearing science research. It will permit researchers to more rapidly and easily test new algorithms with greater control, performance, and ease. Several example systems will be created to show that the platform can be ad ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  3. A Hand-Held Robot to Cure BPH

    SBC: Virtuoso Surgical, Inc.            Topic: NIBIB

    Project Summary AbstractThe objective of this proposal is to transform a hand held surgical robotic system for transurethral laser prostate surgery from a lab prototype into a commercial productThe system will feature needle sized arms deployed through the endoscope port and will enable independent tissue manipulationlaser aimingand visualizationmaking surgery more accurate and ef cientClinical si ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Long non-coding RNA signatures to classify multiple sclerosis

    SBC: IQuity Labs, Inc.            Topic: NIAID

    Diagnosis of relapsing remitting multiple sclerosisMSrests on clinical symptoms and examinations asoutlined in the revised McDonald s criteria supported by appropriate magnetic resonance imaging findings andother laboratory testsThe need for early diagnosis is clearly emphasized in a position paper produced inby MS Brain Health organization calledBrain healthTime matters in multiple sclerosiswhich ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Nutritional Therapy in Elderly with Heart Failure

    SBC: Essential Blends, LLC            Topic: NIA

    Project Summary Abstract We have developed a nutritional formulation of amino acids called UpBeat that is designed to promote physical function and quality of life in older individuals with heart failureReduced exercise capacity is a prominent clinical feature of heart failureThis leads to progressive muscle weakness and a vicious cycle of sedentary behaviorweight gainand subsequent development of ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Mouse Stem Cell Research Using the Dracula Pipette

    SBC: GENESEARCH, INC.            Topic: 100

    Advanced approaches for genetic or epigenetic modification of embryonic stemEScellsincluding TALENZFNor CRISPR catalyzed genetic modifications or modulation of gene expression via small RNAssynthetic mRNAsor recombinant transcription factorshave revolutionized our ability to modify the cells from which novel mouse lines are producedIn contrastprocedures for utilizing these cells within the context ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a high-throughput screen to detect the effects of both pre- and post-biotransformed compounds for enhanced content drug discovery workflows

    SBC: 490 BIOTECH INC            Topic: 300

    Development of a high throughput screen to detect the effects of both preand postbiotransformed compounds for enhanced content drug discovery workflows Project Summary This Small Business Innovation Research Phase II project will build upon our successful Phase I demonstration that substrate free autobioluminescent signal generation can detect both the preand post biotransformed metabolic impacts ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Expressing humanized bacterial luciferase in stem cells: Moving beyond fireflyluciferase to expand the informational capacity of animal models for regenerativemedicine

    SBC: 490 BIOTECH INC            Topic: 400

    Expressing humanized bacterial luciferase in stem cellsMoving beyond firefly luciferase toexpand the informational capacity of animal models for regenerative medicine Project Summary This Small Business Technology TransferSTTRPhase II project proposes to develop complementary autonomously bioluminescentautobioluminescentin vitro stem cell lines and in vivo small animal model systems that enable th ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Development of the first thermolytic to suppress shivering and seizure

    SBC: Be Cool Pharmaceutics LLC            Topic: NHLBI

    Summary The temperature management market is expected to reach $billion byyet no pharmaceutical has yet been developed specifically for this marketAadenosineA ARagonists are well known to attenuate seizure and protect the brain from injurybut development of these drugs has been limited by side effects including hypothermiabradycardia and hypotensionInspired by our discoveries thatN cyclohexyl aden ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Development of technologies to advance fast and accurate tools for measuring fluorescence in living cells, with emphasis on developing assays optimized for screening in neuronal cells and brain tissue

    SBC: Montana Molecular LLC            Topic: 105

    Project SummaryMontana Molecular is in the business of developing and marketing genetically encoded biosensors for academic research and drug discovery in living cellsOur biosensors provide robust detection of crucial second messenger signalingincluding DAGPIPcAMP and Caon both fluorescence microscopes and the large installed base of automated plate readerswith metrics that match or surpass those ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
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