Award Data

Combat soldiers are exposed to vast numbers of dangerous chemicals with potentially adverse health outcomes. This SBIR proposal aims to develop a new class of saliva based diagnostic assays that will measure the bodys response to toxic chemical exposure with a panel of clinically validated biomarkers that are indicative of organ injury. The tests will leverage the proven functionality of lateral ...

Trauma is the most common cause of death in ages 1-48. Uncontrolled hemorrhage in the torso is the leading cause of preventable death in military combatants and civilian trauma patients with otherwise survivable injuries. The prospects for survival from hemorrhage-induced traumatic cardiac arrest (HiTCA) are dismal with only about a 1% survival rate. Advances in endovascular technologies have led ...

DoD requires a single, multiplexed, saliva-based diagnostic bioassay to determine multiorgan injury-relevant systemic toxicity. This assay should quantitatively-detect clinically relevant biomarkers in saliva and validate organ injury arising from chemical/xenobiotic exposure. Innosense LLC (ISL) is building on its proprietary carbon nanotube platform to construct Nano-Mos for detecting salivary b ...

Rapid diagnosis in conflict areas is a growingmilitary need, as troops areexposed to chemical threats (http://www.army.mil/e2/c/downloads/351235.pdf). Testingfor biomarkers in saliva has recently shown great promisein diagnostics, prognostics, and treatmentefficacy follow-up. In addition to itsconveniencefor field sampling and rapid testing,saliva is a rich body fluid with a number of physiologica ...

Despite recent tremendous leaps in the development of new technologies for image recording, presentation, manipulation, 3D capabilities, and analysis, many vision exams are still performed using paper Snellen charts, paper color charts and Amsler grids. Current procedures are time consuming, labor intensive, potentially subject to transcription errors and test preparation, which may compromise the ...

Existing visual screening devices consist of illuminated test cards. By rotating the knob, images may be changed; however, once the system is loaded with cards it cannot be easily reconfigured. There are a limited number of cards that a unit can hold at one time, and it is impossible to change cards on the fly if a patients vision needs further investigation or if the clinician wants to do variabl ...

There has been considerable interest in the development of alternative therapies for pain management that are neither opioid nor non-steroidal anti-inflammatory drugs (NSAIDs). Kalyra Pharmaceuticals has demonstrated that acetaminophen, also known as APAP

Surgical trainingrequires an understanding of the human body’scomplex3-dimensional anatomical structures and thespatial relationships of nerves, blood vessels and othervital structures.Learningthesespatial skills requires a lengthy training period and much practicethat usually takes placein the operatingroom while under thesupervision of a senior surgeon atgreat financial cost and potential risk ...

A key bottleneck to be addressed in regenerative medicine is hypothermic preservation of cells and tissues, which has been shown to extend survival of cell and tissue-based therapies by decreasing ischemic effect. However, preservation technology is aged, toxic and less effective than desired with typical cell survival post-thaw below 50% and unreliable potency. Current technology greatly hinders ...

Strategic Operations is noted for its rapid prototyping, manufacturing, distribution, and training capabilities; while Vcom3D is a leader in developing and fielding highly effective game-based learning products. The transition from R&D to manufacturing the Blended VR/Manikin Humeral Head IO Trainer for the Army and other military service use and commercialization to the civilian market will be se ...