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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Synthetic Universal Flu Vaccine

    SBC: TRIA BIOSCIENCE CORP.            Topic: NCIRD

    Abstract Type A and B Influenza viruses cause severe seasonal epidemics and less frequent but more deadly pandemic infectionsVaccination provides the best protectionalthough serious problems are confronting the global Influenza marketVirus diversity and mutation rates necessitate the annual production of hundreds of millions of vaccines using antiquated egg based technologiesCompounding this is th ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Engineering Nanoparticle Alum Adjuvants for Pandemic Influenza Vaccines

    SBC: HDT Bio Corp.            Topic: NCIRD

    Project Summary SignificanceSinceavian influenza AH Nhas sickened overpeople with amortality rateHalf of all cases occurred inwhich also saw the emergence of a highly pathogenic strainThusH Navian influenza is poised to emerge as a devastating pandemic in a worldwide population that has no pre existing immunityCurrent Hvaccineswhether attenuatedinactivatedsplit or recombinantare insufficiently imm ...

    SBIR Phase I 2018 Department of Health and Human Services

    SBC: Siteone Therapeutics, Inc.            Topic: N

    PROJECT SUMMARY The absence of safe and effective strategies for the management of ocular pain is motivating the development of a novel topical drug suitable for patient self administrationConventional local anestheticssuch as proparacaineinhibit voltage gated Naion channelsNaVand are highly effective for the management of ocular pain in acutein office settingsHoweverthese agents are short acting ...

    SBIR Phase II 2018 Department of Health and Human Services
  4. High-throughput nanoMEA-based Proarrhythmia Assay


    PROJECT SUMMARY Failure of new drugs at late stages of development is an extremely costly eventcommonly associated with the detection of unexpected arrhythmogenic properties in novel drugsUndetected arrhythmia inducing effects are also a common reason for drug withdrawal from the marketAs a resultthe FDA now mandates that all new drugs be tested for potential arrhythmogenic propertieswhich has led ...

    SBIR Phase II 2018 Department of Health and Human Services
  5. Selective inhibition of CYP26A1 in the skin for the treatment of ichthyosis

    SBC: Dermaxon LLC            Topic: NIAMS

    Project SummaryAbstract DermaXon s project goal is to develop efficacious substrate based and highly selective inhibitors of CYPsthe enzymes responsible or retinoic acidRAmetabolism in the epidermisfor the topical treatment of ichthyosisThis approach will provide a therapeutic advantage in ichthyosis without the potential adverse effects mediated by non targeted Pinhibitionassociated with previous ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. Highly Sensitive Chimerism Testing to Detect Early Leukemia Relapse Post-Allo-Transplantation

    SBC: Chimerocyte, Inc.            Topic: 102

    ABST RACT Patients with acute blood malignancies who undergo allogeneic hematopoietic stem cell transplantationHSCTare monitored for minimal residual diseaseMRDas predictive of relapseIncreasing mixed chimerismreemerging recipient cellscorrelates with reappearance of underlying disease by association with MRDGenetic and immunophenotypic heterogeneity of these malignancies often prevents establishi ...

    STTR Phase I 2018 Department of Health and Human Services
  7. Automated Contingency Management System for Reduction of Alcohol Use

    SBC: Managed Health Connections LLC            Topic: 450

    Project Summary Abstract Alcohol abuse remains a significant cause of preventable morbidity and mortality in the USYet onlyof those with AUD receive treatmentOur groupand others have demonstrated that contingency managementCMis an effective approach for reducing alcohol use in problematic drinkersThis project seeks to demonstrate the capability of an end to end CM platform designed to reduce alcoh ...

    STTR Phase I 2018 Department of Health and Human Services
  8. Transforming STEM Education in K-12 using the Biological Interactive Outcomes Modular Environment (BIOME)

    SBC: IQ Smart Interactive LLC            Topic: 500

    PROJECT SUMMARYThe United States is falling behind in Science and Math according to results from the Programme for International Student AssessmentPISAranking the US asth in Science andth in Mathematics out ofcountriesThese unfortunate statistics could be attributed to teacher hesitations in teaching math and scienceinability to excite student interest in STEM subjectsor an unclear real world appl ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Development of a PSMA-Targeted Small-Molecule Drug Conjugate for Prostate Cancer


    PROJECT SUMMARY ABSTRACTProstate Specific Membrane AntigenPSMAis an andapos ideal biomarkerandaposfor tumor targeting as it exhibits restricted expression on prostate tumor cells and the neovasculature of a number of other solid tumorsCancer Targeted Technology has developed unique phosphoramidate based PSMA inhibitor scaffolds that irreversibly bind to the enzyme target and selectively penetrate ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. NV103: Antibody Conjugated Nanoparticle for Ewing Sarcoma Targeted Therapy

    SBC: NanoValent Pharmaceuticals, Inc.            Topic: 102

    Project Summary This Phase II SBIR project seeks to demonstrate that noveltargetable nanoparticles can delivery therapeutic substances to human tumor cells and reduce tumor burden in cancerThe concept for these nanoparticles is based on the hybrid polymerized liposome nanoparticleHPLNthat displays functional antibodies that target tumor cell surface markersThe therapeutic cargos are encapsulated c ...

    SBIR Phase I 2018 Department of Health and Human Services

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