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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Therapeutic TRPA Mechanism Based Treatment of Chemotherapeutic Induced Neuropathic Pain

    SBC: ALGOMEDIX, INC.            Topic: 102

    Abstract Cancer patients treated with many widely used chemotherapeutic agents including paclitaxel PAC and oxaliplatin OXA frequently develop chemotherapy induced peripheral neuropathy CIPN that may lead to dose reduction dosing schedule changes and termination of treatment In some patients acute peripheral neuropathy PN can transition into chronic PN lasting well beyond termination ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. A Nanopatterned Interdigitated Electrode Array Device for Anti migratory Cancer Drug Screening

    SBC: NANOSURFACE BIOMEDICAL, INC.            Topic: 102

    PROJECT SUMMARY As the cancer drug industry suffers from the lowest success rate in developing cancer cure drugs cell migration assessment assays that evaluate the transition of cells from a benign to a metastatic phenotype have gained more attention Given the fact that metastatic cancer cells are substantially harder to eradicate than those that are benign migratory propensity is now understoo ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Using Serious STEM Interactive Digital Technology To Understand Agriculture

    SBC: MEADOWLARK SCIENCE AND EDUCATION, LLC            Topic: 500

    PROJECT SUMMARY Improving STEM focused curriculum is a primary objective of the current U S administration and is crucial for ensuring that upcoming generations receive the training and skills necessary to compete in the existing global economy To that end there is an urgent need for additional effective teaching tools able to reach a generation that requires instant access to information and a ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Ultra Bright Fluorescent Probes for Flow Cytometry

    SBC: LAMPROGEN INC            Topic: 100

    Project Summary For modern flow cytometry high throughput multiplexing is extremely important because of the great need in analyzing a large number of biomolecules on and in a single cell The multiplexing performance of flow cytometry is hindered by the probe performance including their fluorescence brightness and emission bandwidth However there is renewed interest and effort to develop high ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Range Encoded Difference Compression of EEG on a chip for Implantable Devices

    SBC: NEURALYNX INC            Topic: 101

    Large scale electrophysiology recordings are recognized as a powerful tool for systems neurobiology and investigation of normal and pathological brain function Buzsaki Continuous high spatial and temporal resolution intracranial electroencephalography iEEG and single neuron recordings from animals and humans are increasingly being used to investigate both normal and pathologic brain f ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Rational drug selection for Alzheimer s disease using Indicator Cell Assay Platform iCAP

    SBC: PreCyte Inc            Topic: NIA

    Project Summary We are developing a novel tool for disease diagnosis called the indicator cell assay platform iCAP that uses standardized cultured cells as biosensors to detect disease status of patients from blood or cerebral spinal fluid CSF samples Here we propose to establish proof of concept for applying the assay to drug discovery by initiating development of the iCAP for drug selectio ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A Novel Tolerance Therapeutic for Treating Type Diabetes

    SBC: VIRTICI LLC            Topic: 200

    Project Summary Our goal is to develop VTC D as a novel tolerance inducing therapeutic for the treatment of Type Diabetes T D T D is an autoimmune disease characterized by the destruction of the insulin producing pancreatic beta cells While the etiology of T D remains undefined evidence suggests that autoimmunity to insulin is a major driver of disease initiation Each year over ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Clinical Study of an Extended Patency Dialysis Access Graft

    SBC: HEALIONICS CORPORATION            Topic: 300

    Clinical Study of an Extended Patency Dialysis Access Graft PROJECT SUMMARY Objective The goals of this PAR Clinical Studies Fast Track SBIR proposal are to move a novel hemodialysis access graft design to k submission and upon k clearance conduct a patient clinical study to demonstrate improved performance compared to current synthetic grafts which have high rate of clot ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Integrating CNV analysis into a NextGen sequencing clinical analytics platform

    SBC: Golden Helix, Inc.            Topic: 400

    Copy Number Variations CNVs are a common cause of disease in humans As of today CNVs are most often detected using microarrays However microarrays are expensive and are not able to effectively detect CNVs below K bp range This project is designed to detect both point mutations and CNVs in one clinical test without having to utilize microarrays It is our goal to develop an easy to use solu ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Development of the first thermolytic to suppress shivering and seizure

    SBC: Be Cool Pharmaceutics LLC            Topic: NHLBI

    Summary The temperature management market is expected to reach $ billion by yet no pharmaceutical has yet been developed specifically for this market A adenosine A AR agonists are well known to attenuate seizure and protect the brain from injury but development of these drugs has been limited by side effects including hypothermia bradycardia and hypotension Inspired by our discover ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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