Award Data

DESIGN AND FABRICATION OF SOLID-STATE DIRECTION-INDICATING APPARATUS, WITH TILT-IMMUNITY, THAT PROVIDES AN AUDIBLE OR TACTILE INTERFACE WITH THE USER. REDUCED SIZE TO ALLOW ENCAPSULATION IN A TYPICAL WALKING CANE. A DEVICE WILL BE DESIGNED THAT WILL PROVIDE A VISUALLY IMPAIRED PERSON WITH AN INDICATION OF HORIZONTAL DIRECTION, WITH RESPECT TO THE EARTH'S MAGNETIC FIELD. THE DEVICE WILLALSO SIGNAL ...

THIS PROPOSAL REQUESTS DEPARTMENT OF EDUCATION SUPPORT FOR EDMARK, A SMALL BUSINESS IN BELLEVUE, WASHINGTON, TO DEVELOPAND FIELD-TEST A HARDWARE/SOFTWARE PACKAGE TO ADDRESS THE POSSIBLE DISABILITIES BY TEACHERS AND PARAPROFESSIONALS. PUBLIC LAW 99-457 REQUIRES THE IDENTIFICATION AND PROVISION OF SERVICES TO YOUNG CHILDREN WITH DISABILITIES. QUALIFIED PERSONAL, REMOTE LOCATION, OR OTHER REASONS. A ...

THE PROGRESSIVE SCIENCE INSTRUCTION PACKAGE WILL BE A SOFTWARE AND COURSEWARE PACKAGE WHICH WILL TEACH SCIENCE IN GRADES 6-9 TO STUDENTS WHOSE NATIVE LANGUAGE IS NOT ENGLISH. STUDENTS USING THE PACKAGE WILL LEARN SCIENCE MATERIAL IN MICROCOMPUTER-BASED TUTORIAL DIALOGS THAT INCORPORATE INTERACTIVE VIDEO, GRAPHICS, AND MULTIPLE LEVELSOF TEXTUAL RESPONSES AND REMEDIATIONS. THE STUDENTS WILL WORK PAP ...

The project team is developing a prototype of Eco, a multi-player game to prepare high school students to be environmentally literate citizens with 21st century skills. To play the game, students will enter a shared online world featuring a simulated ecosystem of plants and animals. Students will co-create the civilization by measuring, modeling, and analyzing the underlying ecosystem. Students ad ...

DESCRIPTION (provided by applicant): The goal of this project is to extend the development of a novel compound that can reprogram memory T lymphocytes to induce tolerance in allergic rhinitis (AR). AR is one of the most common chronic diseases in the United States (US) and is estimated to affect more than 50 million people [1,2]. As a result, the annual US economic burden of AR exceeds 12 billio ...

DESCRIPTION (provided by applicant): The purpose of this proposal is to adapt a technology that we have developed for monitoring residual disease in leukemia patients to monitor residual autoimmune disease in Celiac Disease patients. Celiac disease hasa significant burden on quality of life, as it is one of the most frequent autoimmune diseases, with an estimated prevalence of approximately 1% ...

Project Summary Tumors survive cancer therapy in part by blocking the entrance and permeation of drugs into the cancer. We have developed a therapeutic, JO-1 , that selectively opens up tumors, which dramatically enhances penetration. This results in markedly increased concentrations of cancer drugs in the tumor, which becomes a sink , thereby reducing drug levels in the rest of the body. JO-1 m ...

DESCRIPTION (provided by applicant): With the discovery of new biomarkers associated with tumor development, many of these tumor-associated antigens (TAA) are being utilized in immunotherapeutic modalities designed to induce anti-tumor directed cytotoxicimmune responses. It is increasingly clear that not any one of these TAA is sufficient, as a single entity to develop an immunotherapeutic treatm ...

DESCRIPTION (provided by applicant): Lung cancer is the most prevalent cancer worldwide and responsible for the most cancer deaths in the United States. Existing therapies include surgery, radiation, or chemotherapy to kill the tumor cells, but these options are not adequate for the vast majority of patients. Thus, there is a significant need to develop new therapeutic approaches. One of the most ...

DESCRIPTION (provided by applicant): Aminoglycoside antibiotics (AGs) are important for the treatment of a variety of serious infectious diseases including septicemia, complicated intra-abdominal infections, complicated urinary tract infections, and nosocomial respiratory tract infections. AGs are the mainstay of treating Pseudomonas infection in patients with cystic fibrosis and one of the best c ...