Award Data

Abstract Cancer patients treated with many widely used chemotherapeutic agents including paclitaxel PAC and oxaliplatin OXA frequently develop chemotherapy induced peripheral neuropathy CIPN that may lead to dose reduction dosing schedule changes and termination of treatment In some patients acute peripheral neuropathy PN can transition into chronic PN lasting well beyond termination ...

PROJECT SUMMARY As the cancer drug industry suffers from the lowest success rate in developing cancer cure drugs cell migration assessment assays that evaluate the transition of cells from a benign to a metastatic phenotype have gained more attention Given the fact that metastatic cancer cells are substantially harder to eradicate than those that are benign migratory propensity is now understoo ...

Project Summary There is an urgent unmet need for simplified and improved blood testing systems that can be utilized outside of centralized clinical settingsBlood cancers are a major health problem in the United Statesrepresenting overof all new cancersAcute myeloid leukemiaAMLis a particularly fast evolving form of cancer with low rates of survivalFollow initial therapy treatmentsAML patients mus ...

PROJECT SUMMARY Improving STEM focused curriculum is a primary objective of the current U S administration and is crucial for ensuring that upcoming generations receive the training and skills necessary to compete in the existing global economy To that end there is an urgent need for additional effective teaching tools able to reach a generation that requires instant access to information and a ...

Project Summary For modern flow cytometry high throughput multiplexing is extremely important because of the great need in analyzing a large number of biomolecules on and in a single cell The multiplexing performance of flow cytometry is hindered by the probe performance including their fluorescence brightness and emission bandwidth However there is renewed interest and effort to develop high ...

ABSTRACT Thetis plans to investigate TP an innovative and potential first in class therapeutic agent as an oral therapy for the induction and maintenance of remission of intestinal inflammation symptoms in ulcerative colitis UC patients While the precise etiology of UC is unknown it is thought to result from an inappropriate inflammatory response to commensal gut bacteria in genetically ...

Large scale electrophysiology recordings are recognized as a powerful tool for systems neurobiology and investigation of normal and pathological brain function Buzsaki Continuous high spatial and temporal resolution intracranial electroencephalography iEEG and single neuron recordings from animals and humans are increasingly being used to investigate both normal and pathologic brain f ...

Project Summary We are developing a novel tool for disease diagnosis called the indicator cell assay platform iCAP that uses standardized cultured cells as biosensors to detect disease status of patients from blood or cerebral spinal fluid CSF samples Here we propose to establish proof of concept for applying the assay to drug discovery by initiating development of the iCAP for drug selectio ...

Project Summary Our goal is to develop VTC D as a novel tolerance inducing therapeutic for the treatment of Type Diabetes T D T D is an autoimmune disease characterized by the destruction of the insulin producing pancreatic beta cells While the etiology of T D remains undefined evidence suggests that autoimmunity to insulin is a major driver of disease initiation Each year over ...

Clinical Study of an Extended Patency Dialysis Access Graft PROJECT SUMMARY Objective The goals of this PAR Clinical Studies Fast Track SBIR proposal are to move a novel hemodialysis access graft design to k submission and upon k clearance conduct a patient clinical study to demonstrate improved performance compared to current synthetic grafts which have high rate of clot ...