Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. A high throughput sample preparation platform for genomic and epigenetic analysis

    SBC: Matchstick Technologies Inc.            Topic: 200

    Several types of cancers e g pancreatic and brain malignancies remain extremely lethal despite the introduction of chemotherapy more than years ago The hallmark of all cancers are somatic mutations which cannot be corrected In sharp contrast epigenetic changes essential contributors to tumorigenesis are pharmacologically reversible The ability to remedy detrimental epigenetic alteratio ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. A Phase Clinical Trial Evaluating the Novel Small Molecule Immuno Oncology Antagonist SX Alone and With Pembrolizumab in Metastatic Melanoma

    SBC: Syntrix Biosystems, Inc.            Topic: 102

    The chemokine receptors CXCR and CXCR CXCR are validated as having essential roles in the growth survival motility invasion and angiogenesis of human melanoma which secretes abundant amounts of the corresponding chemokine ligands including CXCL Additionally abnormal cancer induced immunosuppressive myeloid derived suppressor cells MDSCs in the circulation and tumor correlate with ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Development of the first thermolytic to suppress shivering and seizure

    SBC: Be Cool Pharmaceutics LLC            Topic: NHLBI

    Summary The temperature management market is expected to reach $billion byyet no pharmaceutical has yet been developed specifically for this marketAadenosineA ARagonists are well known to attenuate seizure and protect the brain from injurybut development of these drugs has been limited by side effects including hypothermiabradycardia and hypotensionInspired by our discoveries thatN cyclohexyl aden ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Clinical Study of an Extended Patency Dialysis Access Graft

    SBC: HEALIONICS CORPORATION            Topic: 300

    Clinical Study of an Extended Patency Dialysis Access Graft PROJECT SUMMARY Objective The goals of this PAR Clinical Studies Fast Track SBIR proposal are to move a novel hemodialysis access graft design to k submission and upon k clearance conduct a patient clinical study to demonstrate improved performance compared to current synthetic grafts which have high rate of clot ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. HLS Potent novel inhibitor of fibrinolytic hemorrhage

    SBC: Translational Sciences Inc.            Topic: NHLBI

    This SBIR Application is responsive to NHLBI Small Business Topics of Special Interest therapeutics that are of high programmatic interest HL Hemorrhage or bleeding is a serious or fatal complication of surgery Antifibrinolytic agents that inhibit plasmin mediated fibrinolysis can significantly reduce blood loss emergency reoperation morbidity and death in patients with severe hemor ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. " Channel Multimodal Ultrathin Flexible SFE for cancer diagnosis and therapy"

    SBC: VERAVANTI INC.            Topic: 102

    Summary channel multimodal ultrathin flexible SFE for cancer diagnosis and therapy Minimally invasive optical imaging is being advanced by molecular probes that enhance contrast using fluorescence The applications in cancer imaging are very broad ranging from early diagnosis of cancer to the guiding of interventions such as surgery The high sensitivity afforded by wide field fluorescence i ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A Novel Tolerance inducing Probiotic Platform

    SBC: VIRTICI LLC            Topic: NIAID

    Project Summary Our goal is to validate a novel Lactococcus lactis L lactis based platform to rapidly develop and deliver tolerance inducing therapeutics for the treatment of autoimmunity and allergy Autoimmune and allergic diseases such as Multiple Sclerosis MS Type Diabetes and food allergies affect of the world population and are continuing to rise These illnesses are the ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A Novel Tolerance Therapeutic for Treating Type Diabetes

    SBC: VIRTICI LLC            Topic: 200

    Project Summary Our goal is to develop VTC D as a novel tolerance inducing therapeutic for the treatment of Type Diabetes T D T D is an autoimmune disease characterized by the destruction of the insulin producing pancreatic beta cells While the etiology of T D remains undefined evidence suggests that autoimmunity to insulin is a major driver of disease initiation Each year over ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Rational drug selection for Alzheimer s disease using Indicator Cell Assay Platform iCAP

    SBC: PreCyte Inc            Topic: NIA

    Project Summary We are developing a novel tool for disease diagnosis called the indicator cell assay platform iCAP that uses standardized cultured cells as biosensors to detect disease status of patients from blood or cerebral spinal fluid CSF samples Here we propose to establish proof of concept for applying the assay to drug discovery by initiating development of the iCAP for drug selectio ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Early Detection of Ovarian Cancer Using Uterine Lavage and Duplex Sequencing

    SBC: Twinstrand Biosciences, Inc.            Topic: 102

    Early Detection of Ovarian Cancer Using Uterine Lavage and Duplex Sequencing Nearly a quarter of a million new cases of ovarian cancer are identified every year worldwide and the majority of these woman will die from their disease When detected early surgical cure rates exceed but currently most cases are detected at an advanced stage when the cancer has already disseminated As such our m ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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