Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. A Computer Model of Renal Physiology for use as a FDA Medical Device Development Tool

    SBC: HC Simulation, LLC            Topic: FDA

    The purpose of this proposal is to develop a validated physiological model of the human physiologyespecially the cardio renal axisfor submission to the FDA Medical Device Development Tool pilot programThe model will be used to aid in the development and regulation of medical devices designed to treat hypertensionExamples include devices for renal nerve ablationelectrical stimulation of the carotid ...

    SBIR Phase II 2018 Department of Health and Human Services
  2. A high-throughput sample preparation platform for genomic and epigenetic analysis

    SBC: Matchstick Technologies Inc.            Topic: 400

    Several types of cancerse gpancreatic and brain malignanciesremain extremely lethal despite the introduction of chemotherapy more thanyears agoThe hallmark of all cancers are somatic mutations which cannot be correctedIn sharp contrastepigenetic changesessential contributors to tumorigenesisare pharmacologically reversibleThe ability to remedy detrimental epigenetic alterations are opening up new ...

    SBIR Phase II 2017 Department of Health and Human Services
  3. A Novel Peptide Therapeutic for Obesity

    SBC: VIRTICI LLC            Topic: 300

    Project Summary The goal of this project is to develop a novel peptide therapeuticVTC Gfor the treatment of obesityTodayone third of adults in the United StatesUSare obesewith an estimated annual healthcare burden of approximately $billionByit is projected that overof adults in the US will be obese with a yearly healthcare burden expected to exceed $billionwhich will account for approximatelyof th ...

    SBIR Phase II 2017 Department of Health and Human Services
  4. A Novel Tolerance Therapeutic for Treating Multiple Sclerosis

    SBC: VIRTICI LLC            Topic: NIAID

    Our goal is to develop VTC MSas a novel tolerance inducing therapeutic to treat Multiple SclerosisMSMS is the most common demyelinating disorder of the Central Nervous SystemCNSaffecting approximatelymillion people worldwide andin the US aloneCurrent and developing treatment of MS relies mainly on immuno suppression and modulation to reduce inflammatory symptoms creating a significant need for new ...

    SBIR Phase II 2017 Department of Health and Human Services
  5. A Phase 1 Clinical Trial Evaluating the Novel Small Molecule Immuno-Oncology Antagonist SX-682 Alone and With Pembrolizumab in Metastatic Melanoma

    SBC: Syntrix Biosystems, Inc.            Topic: 102

    The chemokine receptors CXCRand CXCRCXCRare validated as having essential roles in the growthsurvivalmotilityinvasion and angiogenesis of human melanomawhich secretes abundant amounts of the corresponding chemokine ligandsincluding CXCLAdditionallyabnormal cancer induced immunosuppressive myeloid derived suppressor cellsMDSCsin the circulation and tumor correlate with melanoma stagemetastatic tumo ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. Advanced Fast Shutter for Debris Mitigation

    SBC: Hyperion Technology Group, Inc.            Topic: DTRA143007

    In an effort to development more robust optical system coatings DTRA, in collaboration with Sandia National Labs, is working to characterize the degradation of optical materials for space systems when exposed to high intensely EUV/ cold x-rays. The experiments utilizes the Double Eagle z-pinch facility which generates high current, high voltage arc pinch plasma to produce an intense EUV and cold x ...

    SBIR Phase II 2017 Department of DefenseDefense Threat Reduction Agency
  7. Aerosol Sampling and Microfluidic Analysis of Reactive Oxygen Species

    SBC: ILLIONIX, LLC            Topic: 113

    DESCRIPTIONprovided by applicantCardiovascular diseases and Asthma affects betweenandmillion people in the United States includingmillion childrenduring the pastyearsits incidence worldwide has doubledAsthma is responsible formillion person days of restricted activity anddeaths per yearamounting to $billion in direct heath related coststhere is uncertainty about the specific factors that are contr ...

    STTR Phase II 2017 Department of Health and Human Services
  8. A Hand-Held Robot to Cure BPH

    SBC: Virtuoso Surgical, Inc.            Topic: NIBIB

    Project Summary AbstractThe objective of this proposal is to transform a hand held surgical robotic system for transurethral laser prostate surgery from a lab prototype into a commercial productThe system will feature needle sized arms deployed through the endoscope port and will enable independent tissue manipulationlaser aimingand visualizationmaking surgery more accurate and ef cientClinical si ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. AlphaBear2

    SBC: Spry Fox LLC            Topic: EDIES17R0006

    This project team will fully develop and test AlphaBear 2, a vocabulary learning game for grade 4 to 7 students. Vocabulary is a prerequisite for academic success, as it is linked to stronger performance across academic subjects and improved reading comprehension. It is more difficult for students to participate in educational activities without understanding the key vocabulary associated with tha ...

    SBIR Phase II 2017 Department of EducationInstitute of Education Sciences
  10. An Automated Early Motor Development Risk Screener from Observational Video Recordings of Infants and Toddlers

    SBC: BSolutions Inc            Topic: NICHD

    Motor development plays a pivotal role in an infant s overall development and has a cascading effect on socialcognitivememoryand language abilityThese functions can be compromised when motor development is disruptedmotor disruption is associated with generalized developmental delaysEarly screening and identification of delays can allow early interventions with the goal of not just improving motor ...

    SBIR Phase II 2018 Department of Health and Human Services
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