Award Data

In an effort to development more robust optical system coatings DTRA, in collaboration with Sandia National Labs, is working to characterize the degradation of optical materials for space systems when exposed to high intensely EUV/ cold x-rays. The experiments utilizes the Double Eagle z-pinch facility which generates high current, high voltage arc pinch plasma to produce an intense EUV and cold x ...

DESCRIPTIONprovided by applicantCardiovascular diseases and Asthma affects betweenandmillion people in the United States includingmillion childrenduring the pastyearsits incidence worldwide has doubledAsthma is responsible formillion person days of restricted activity anddeaths per yearamounting to $billion in direct heath related coststhere is uncertainty about the specific factors that are contr ...

Project Summary AbstractThe objective of this proposal is to transform a hand held surgical robotic system for transurethral laser prostate surgery from a lab prototype into a commercial productThe system will feature needle sized arms deployed through the endoscope port and will enable independent tissue manipulationlaser aimingand visualizationmaking surgery more accurate and ef cientClinical si ...

Several types of cancerse gpancreatic and brain malignanciesremain extremely lethal despite the introduction of chemotherapy more thanyears agoThe hallmark of all cancers are somatic mutations which cannot be correctedIn sharp contrastepigenetic changesessential contributors to tumorigenesisare pharmacologically reversibleThe ability to remedy detrimental epigenetic alterations are opening up new ...

This project team will fully develop and test AlphaBear 2, a vocabulary learning game for grade 4 to 7 students. Vocabulary is a prerequisite for academic success, as it is linked to stronger performance across academic subjects and improved reading comprehension. It is more difficult for students to participate in educational activities without understanding the key vocabulary associated with tha ...

Motor development plays a pivotal role in an infant’s overall development and has a cascading effect on social, cognitive, memory, and language ability. These functions can be compromised when motor development is disrupted; motor disruption is associated with generalized developmental delays. Early screening and identification of delays can allow early interventions with the goal of not just im ...

Project Summary The goal of this project is to develop a novel peptide therapeuticVTC Gfor the treatment of obesityTodayone third of adults in the United StatesUSare obesewith an estimated annual healthcare burden of approximately $billionByit is projected that overof adults in the US will be obese with a yearly healthcare burden expected to exceed $billionwhich will account for approximatelyof th ...

Our goal is to develop VTC MSas a novel tolerance inducing therapeutic to treat Multiple SclerosisMSMS is the most common demyelinating disorder of the Central Nervous SystemCNSaffecting approximatelymillion people worldwide andin the US aloneCurrent and developing treatment of MS relies mainly on immuno suppression and modulation to reduce inflammatory symptoms creating a significant need for new ...

The chemokine receptors CXCR1 and CXCR2 (CXCR1/2) are validated as having essential roles in the growth, survival, motility, invasion and angiogenesis of human melanoma, which secretes abundant amounts of the corresponding chemokine ligands, including CXCL8. Additionally, abnormal cancer-induced immunosuppressive myeloid-derived suppressor cells (MDSCs) in the circulation and tumor correlate with ...

PROJECT ABSTRACTOver 44,000 people die annually by suicide in the United States (US) making suicide the 10th leading cause of death overall and the second leading cause of death among those 10-44. In addition, 9.8 million adults contemplate suicide annually, and one million will make a suicide attempt. From 2006 to 2013, the rate of ED visits for suicidal ideation among adults increased by 12% on ...