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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. GUANIDINIUM DERIVATIVES FOR THE TREATMENT OF OCULAR PAIN

    SBC: SITEONE THERAPEUTICS, INC.            Topic: N

    PROJECT SUMMARY The absence of safe and effective strategies for the management of ocular pain is motivating the development of a novel topical drug suitable for patient self administrationConventional local anestheticssuch as proparacaineinhibit voltage gated Naion channelsNaVand are highly effective for the management of ocular pain in acutein office settingsHoweverthese agents are short acting ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Novel Methodology for Identification of Senolytics that Reduce Age-related Disease and Dysfunction

    SBC: Recursion Pharmaceuticals, LLC            Topic: NIA

    DESCRIPTION (provided by applicant): Chronic diseases of aging account for a significant proportion of healthcare spending and result in a painful and limiting existence for many tens of millions of Americans and hundreds of millions of people around the world. Recursion Pharmaceuticals has developed a drug discovery platform that re-purposes known drugs for the treatment of such diseases. The pla ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. High-throughput nanoMEA-based Proarrhythmia Assay

    SBC: CURI BIO, INC.            Topic: NHLBI

    PROJECT SUMMARY Failure of new drugs at late stages of development is an extremely costly event commonly associated with the detection of unexpected arrhythmogenic properties in novel drugs Undetected arrhythmia inducing effects are also a common reason for drug withdrawal from the market As a result the FDA now mandates that all new drugs be tested for potential arrhythmogenic properties which ha ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Selective inhibition of CYP26A1 in the skin for the treatment of ichthyosis

    SBC: DERMAXON LLC            Topic: NIAMS

    Project SummaryAbstract DermaXon s project goal is to develop efficacious substrate based and highly selective inhibitors of CYPsthe enzymes responsible or retinoic acidRAmetabolism in the epidermisfor the topical treatment of ichthyosisThis approach will provide a therapeutic advantage in ichthyosis without the potential adverse effects mediated by non targeted Pinhibitionassociated with previous ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Early Detection of Ovarian Cancer Using Uterine Lavage and Duplex Sequencing

    SBC: TWINSTRAND BIOSCIENCES INC            Topic: 102

    Nearly a quarter of a million new cases of ovarian cancer are identified every year worldwide and the majority of these woman will die from their disease. When detected early, surgical cure rates exceed 90%, but currently most cases are detected at an advanced stage when the cancer has already disseminated. As such, our most pressing problem in ovarian cancer is a lack of tools to identify early s ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. An Automated Early Motor Development Risk Screener from Observational Video Recordings of Infants and Toddlers

    SBC: BSOLUTIONS, INC.            Topic: NICHD

    Motor development plays a pivotal role in an infant’s overall development and has a cascading effect on social, cognitive, memory, and language ability. These functions can be compromised when motor development is disrupted; motor disruption is associated with generalized developmental delays. Early screening and identification of delays can allow early interventions with the goal of not just im ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Targeting DNA damage response pathways for the treatment of advanced lung cancer

    SBC: CUMBERLAND PHARMACEUTICALS, INC.            Topic: 102

    ABSTRACTThere is an urgentunmet need for novel therapeutic approaches that are efficacious against lung cancerRanking first among cancer deaths in the U Sthis disease hasyear relative survival rates of andltMost lung cancers are non small cellNSCLCof casesCurative surgery is not an option for theof NSCLC patients who present with advanced stage III cancerFor these patients chemo radiation therapy ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Sleeping Beauty Engineered B Cells for Mucopolysaccharidosis

    SBC: IMMUSOFT CORP            Topic: 300

    Project Summary Mucopolysaccharidosis type IMPS Iis an autosomal recessive storage disease caused by the absence ofL iduronidaseIDUAresulting in systemic accumulation of glycosaminoglycanGAGstorage materialshepatosplenomegalyskeletal dysplasiascardiopulmonary obstructionprogressive neurologic impairment and death by ageMPS I is currently treated by enzyme replacement therapy and by allogeneic hema ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Integrating CNV analysis into a NextGen sequencing clinical analytics platform

    SBC: Golden Helix, Inc.            Topic: 400

    Abstract The goal of this project is to develop a commercial analysis software platform that features the ability to detect and interpret copy number variantsCNVsand other types of structural variationsSVsfrom short read NextGen SequenceNGSdata to enable comprehensivewidely accessibleand economical genetic testingThis capability is key in clinical and research applicationsFor examplecurrently clin ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Targeted Polymerized Shell Microbubbles to Image and Treat Surgical Adhesions

    SBC: NANOVALENT PHARMACEUTICALS INC            Topic: 300

    Project Summary The long term goal of this Phase II SBIR project is to develop a commercially viable ultrasound contrast reagentUCRthat will allow the noninvasive identification and treatment of newly forming abdominal adhesions after surgerySuccessful implementation would have significant impact because we would both improve patient post surgical monitoring and considerably reduce the cost of adh ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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