Award Data

"The increasing complexity of devices, reduced budgets and accelerated program timelines, requires a new approach to predicting radiation of integrated circuit (IC) designs. Most approaches to date require gate level analysis and do not scale easily to device level calculations, leading to methods that are not practical under most program timeline and cost budgets. Previously, DfR Solutions has ...

Significance Despite decreases in the overall number of new breast cancer BC cases reported in the US annually there are still about BC deaths annually from metastatic breast cancer MBC Thus the ability to monitor MBC is important to determine disease status and therapy response While the gold standard imaging is expensive time consuming and slow to detect disease response o ...

This proposal addresses the NICHD focus of specific interest for the prevention of child abuse and neglect in at risk populationsChild abuse and neglect often confers shortand long term impairment of the physicalemotionaland cognitive development of childrenThe proposed project builds on promising data from previous randomized control trialsbased on application of a screening tool in primary care ...

In prior projects, including a 2015 ED/IES SBIR award, the team developed two immersive multiplayer virtual game environments. In Eco and Colony, middle school students collaboratively apply scientific practices within the virtual worlds to address challenges, such as the availability of resources and energy and maintaining clean water. With this Phase I funding, the team is developing a prototype ...

This Small Business Innovation Research Phase II project will develop a commercially viable device that uses micro scale acoustic streaming low frequency sound energy to deliver mixing to the interior of three dimensional D scaffolds used for stem cell cultivation applications The enabling advantage of low frequency sound energy is the ability to generate micro scale mixing in and around sca ...

African American men have the highest incidence of prostate cancer PCa are more than twice as likely to die than Caucasian men in the US Underlying factors that cause this disparity have yet to be confirmed in functional studies as representative in vitro models are not readily available to the research community This problem has two origins First a diverse source of PCa tumor cells from rep ...

In an effort to development more robust optical system coatings DTRA, in collaboration with Sandia National Labs, is working to characterize the degradation of optical materials for space systems when exposed to high intensely EUV/ cold x-rays. The experiments utilizes the Double Eagle z-pinch facility which generates high current, high voltage arc pinch plasma to produce an intense EUV and cold x ...

DESCRIPTIONprovided by applicantCardiovascular diseases and Asthma affects betweenandmillion people in the United States includingmillion childrenduring the pastyearsits incidence worldwide has doubledAsthma is responsible formillion person days of restricted activity anddeaths per yearamounting to $billion in direct heath related coststhere is uncertainty about the specific factors that are contr ...

Project Summary AbstractThe objective of this proposal is to transform a hand held surgical robotic system for transurethral laser prostate surgery from a lab prototype into a commercial productThe system will feature needle sized arms deployed through the endoscope port and will enable independent tissue manipulationlaser aimingand visualizationmaking surgery more accurate and ef cientClinical si ...

Several types of cancers e g pancreatic and brain malignancies remain extremely lethal despite the introduction of chemotherapy more than years ago The hallmark of all cancers are somatic mutations which cannot be corrected In sharp contrast epigenetic changes essential contributors to tumorigenesis are pharmacologically reversible The ability to remedy detrimental epigenetic alteratio ...