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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A high throughput sample preparation platform for genomic and epigenetic analysis

    SBC: MATCHSTICK TECHNOLOGIES INC            Topic: 200

    Several types of cancers e g pancreatic and brain malignancies remain extremely lethal despite the introduction of chemotherapy more than years ago The hallmark of all cancers are somatic mutations which cannot be corrected In sharp contrast epigenetic changes essential contributors to tumorigenesis are pharmacologically reversible The ability to remedy detrimental epigenetic alteratio ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. A Phase Clinical Trial Evaluating the Novel Small Molecule Immuno Oncology Antagonist SX Alone and With Pembrolizumab in Metastatic Melanoma

    SBC: Syntrix Biosystems, Inc.            Topic: 102

    The chemokine receptors CXCR and CXCR CXCR are validated as having essential roles in the growth survival motility invasion and angiogenesis of human melanoma which secretes abundant amounts of the corresponding chemokine ligands including CXCL Additionally abnormal cancer induced immunosuppressive myeloid derived suppressor cells MDSCs in the circulation and tumor correlate with ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Clinical Study of an Extended Patency Dialysis Access Graft

    SBC: HEALIONICS CORPORATION            Topic: 300

    Clinical Study of an Extended Patency Dialysis Access Graft PROJECT SUMMARY Objective The goals of this PAR Clinical Studies Fast Track SBIR proposal are to move a novel hemodialysis access graft design to k submission and upon k clearance conduct a patient clinical study to demonstrate improved performance compared to current synthetic grafts which have high rate of clot ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. "Grid-Tape": A High-Throughput Platform for Brain Connectomics and Nanoscale Structural Analysis

    SBC: LUXEL CORP            Topic: 101

    The wiring diagram of brain circuits is one of the foundational and fundamental questions of modern neuroscienceExtracting a circuit sized volume at synaptic resolution requires large scalehigh throughput imaging of many thin sections of brain tissueThe immediate goal of researchers is to capture and map a cubic millimeter of cortex at synaptic resolutionrequiring the collection and imaging oftiss ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. HLS Potent novel inhibitor of fibrinolytic hemorrhage

    SBC: TRANSLATIONAL SCIENCES INC            Topic: NHLBI

    This SBIR Application is responsive to NHLBI Small Business Topics of Special Interest therapeutics that are of high programmatic interest HL Hemorrhage or bleeding is a serious or fatal complication of surgery Antifibrinolytic agents that inhibit plasmin mediated fibrinolysis can significantly reduce blood loss emergency reoperation morbidity and death in patients with severe hemor ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. " Channel Multimodal Ultrathin Flexible SFE for cancer diagnosis and therapy"

    SBC: VERAVANTI INC.            Topic: 102

    Summary channel multimodal ultrathin flexible SFE for cancer diagnosis and therapy Minimally invasive optical imaging is being advanced by molecular probes that enhance contrast using fluorescence The applications in cancer imaging are very broad ranging from early diagnosis of cancer to the guiding of interventions such as surgery The high sensitivity afforded by wide field fluorescence i ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A Novel Tolerance inducing Probiotic Platform

    SBC: VIRTICI LLC            Topic: NIAID

    Project Summary Our goal is to validate a novel Lactococcus lactis L lactis based platform to rapidly develop and deliver tolerance inducing therapeutics for the treatment of autoimmunity and allergy Autoimmune and allergic diseases such as Multiple Sclerosis MS Type Diabetes and food allergies affect of the world population and are continuing to rise These illnesses are the ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A Novel Tolerance Therapeutic for Treating Type Diabetes

    SBC: VIRTICI LLC            Topic: 200

    Project Summary Our goal is to develop VTC D as a novel tolerance inducing therapeutic for the treatment of Type Diabetes T D T D is an autoimmune disease characterized by the destruction of the insulin producing pancreatic beta cells While the etiology of T D remains undefined evidence suggests that autoimmunity to insulin is a major driver of disease initiation Each year over ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Rational drug selection for Alzheimer s disease using Indicator Cell Assay Platform iCAP

    SBC: PRECYTE INC            Topic: NIA

    Project Summary We are developing a novel tool for disease diagnosis called the indicator cell assay platform iCAP that uses standardized cultured cells as biosensors to detect disease status of patients from blood or cerebral spinal fluid CSF samples Here we propose to establish proof of concept for applying the assay to drug discovery by initiating development of the iCAP for drug selectio ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Early Detection of Ovarian Cancer Using Uterine Lavage and Duplex Sequencing

    SBC: TWINSTRAND BIOSCIENCES INC            Topic: 102

    Early Detection of Ovarian Cancer Using Uterine Lavage and Duplex Sequencing Nearly a quarter of a million new cases of ovarian cancer are identified every year worldwide and the majority of these woman will die from their disease When detected early surgical cure rates exceed but currently most cases are detected at an advanced stage when the cancer has already disseminated As such our m ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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