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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of an Ad5 [E1-, E2b-] HIV-1 vaccine for use in Ad5 Immunized Vaccinee

    SBC: Etubics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Current generation Adenovirus (Ad) vector vaccines deleted at the E1 or the E1, E3 regions have resulted in experimental potential to immunize against a variety of infectious diseases such as HIV. These Ad vectors permit the delivery of genes, which express proteins that stimulate the immune system. An advanced generation of Ad vectors with unique deletions of ...

    SBIR Phase II 2009 Department of Health and Human Services
  2. Development of a Novel CEA Expressing Ad5 [E1-, E2b-] Vector for Treatment

    SBC: Etubics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): The objective of this project is to continue to develop an adenoviral vector vaccine against CEA that is effective in stimulating cell-mediated immune responses in subjects previously immune to Adenovirus. The Ad-CEA vaccine endpoint is to treat patients with CEA bearing cancers. CEA is a tumor associated protein that has been reported to be useful as a vaccin ...

    SBIR Phase II 2009 Department of Health and Human Services
  3. Non-Invasive Drug Delivery to Treat Severe Uveitis

    SBC: ACIONT, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The overarching aim of this innovative proposal is to develop and then commercialize a non-invasive topical product which is safe and easy to administer that treats severe uveitis, including intermediate and posterior uveitis. Uveitis is the third leading cause of blindness in the United States. Heretofore, the primary treatments of intermediate and posterior u ...

    SBIR Phase II 2009 Department of Health and Human Services
  4. Real-Time Heteroplasmy Analysis on Microarrays

    SBC: PHILOTEK, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Many human diseases-if not all human diseases-and human health appear to be linked to our genetics. Major government and private research efforts are focused on investigating this linkage. Unfortunately, one of our best tools for this critical work-i.e., microarrays-holds us back, as most provide only generally qualitative results, limiting their usefulness. O ...

    SBIR Phase II 2009 Department of Health and Human Services
  5. Analysis of tracking based phenotypes in CNS

    SBC: DRVISION TECHNOLOGIES LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Project Summary The objective of this project is to develop Prototype and Scale kinetic image recognition software to score tracking based phenotypes in a broad range of microscopy based central nervous system (CNS) applications. The target software tool can be flexibly taught to score or screen the precise dynamic phenotypes of interest, and scalable, togeth ...

    SBIR Phase II 2009 Department of Health and Human Services
  6. Blink Prosthesis for Facial Paralysis Patients

    SBC: RIPPLE, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this program is to create an implantable stimulator device to restore functional eye blink in patients with unilateral facial nerve paralysis. The system will electrically stimulate the paretic eyelid when EMG electrodes detect normal blink from the contralateral eye to produce a synchronous blink. The implant will consist of a thin, ceramic package ...

    SBIR Phase II 2009 Department of Health and Human Services
  7. Anti-HTRA1 Therapy For AMD

    SBC: NAVIGEN, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): In our Phase I application, we proposed that blocking HTRA1 with antibodies might be an effective strategy for treating age related macular degeneration. We tested this hypothesis by a) generating monoclonal antibodies against HTRA1 and b) determining whether a monoclonal antibody would be effective in models of vascular eye disease. We have accomplished each o ...

    SBIR Phase II 2009 Department of Health and Human Services
  8. A Cognitive Behavioral Chronic Pain Workbook

    SBC: TALARIA, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Between 10 and 28 percent of Americans suffer from chronic low back pain (CLBP). Chronic pain self-management programs that include behavioral and cognitive-behavioral therapies (CBT) have been demonstrated as effective in improving pain, function, and quality of life. These techniques are endorsed as an important component of a comprehensive pain management ap ...

    SBIR Phase II 2009 Department of Health and Human Services
  9. BioHDF- Open Binary File Standards for Bioinformatics

    SBC: GEOSPIZA, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The first wave of Next Generation ( Next Gen ) sequencing technologies combines molecular resolution with extremely high throughput to dramatically reduce sequencing costs and increase assay sensitivity and specificity. These technologies will provide large numbers of laboratories with Genome Center levels of throughput to make discoveries and develop new ass ...

    STTR Phase II 2009 Department of Health and Human Services
  10. Venous Window Access Catheter For Hemodialysis

    SBC: VITAL ACCESS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): A novel, venous window access device (VWAD), anastomotic tool, and minimally invasive, image-guided surgical procedure to provide hemodialysis for patients suffering from End Stage Renal Disease (ESRD) have undergone early stage development. The device can serve as a destination therapy or as a bridge device to provide temporary access during maturation of an ...

    SBIR Phase II 2009 Department of Health and Human Services

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