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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 1 - 10 of 5616 results
  1. Small blood pumps for small patients

    SBC: Vadovations, Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant Heart failure and congenital heart defects threaten the lives of several thousand children each year The only FDA approved long term pediatric heart support device is the Berlin Heart Excor which is based on year old technology and is fraught with complications including blood clots forming in the device requiring frequent device replacement The recipien ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Development and validation of therapy for mucopolysaccharidosis III

    SBC: Phoenix Nest Inc.            Topic: 103

    Project Summary Sanfilippo disease (mucopolysaccharidosis type III; MPS III) is a devastating neurodegenerative lysosomal storage disorder of childhood whose pathologic features are neurologic: slowing of development, severe behavioral problems, progressive cognitive decline, dementia, and decline in motor skills leading to immobility, unresponsiveness, and death. We have focused on MPS IIID cause ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a rapid response nucleic acid vaccine strategy for coronavirusepidemics

    SBC: ORLANCE, INC            Topic: NIAID

    ABSTRACT In response to the emerging COVID-19 (SARS-CoV-2) pandemic, this supplement proposal to R44 AI138733- 01 will leverage our cutting-edge nucleic acid vaccine strategies, some of which that were developed under this parent grant. Here, we request supplement funding to develop candidate COVID-19 DNA and RNA vaccines expressing optimally designed immunogens for the SARS-CoV-2 spike protein. N ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Daily and Localized NSAID Sonophoresis for Symptomatic Treatment of Knee Osteoarthritis

    SBC: Zetroz Systems LLC            Topic: R

    Project Summary: Osteoarthritis (OA) is the most common type of arthritis, affecting over 30 million adults in the United States in 2015 and represents over 25% of medical office visits according to the Centers for Disease Control and Prevention and the National Institutes of Health. Over 40% of individuals over 65 have symptomatic OA and reduced mobility due to the disease. OA pain is often mitig ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  5. Knowledge Management System for Multilingual Health Content

    SBC: Transcendent International, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The aim of the proposed project is to develop an advanced, web-based knowledge management system for the creation and distribution of multilingual, patient-oriented documents. The system provides a vast library of pre-translated documents and document templates for medical, educational, and administrative materials used in patient-care. System users will be abl ...

    SBIR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
  6. Preclinical Development of LIGO-069-136, An Anti-Inflammatory Pulmonary Therapeut

    SBC: LIGOCYTE PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The LIGO-069-136 Phase II renewal project is a critical path research and development plan designed to qualify an anti-inflammatory monoclonal antibody product for approval of an investigative new drug (INO) for chronic bronchitis. The proposed mechanism of action of LlGO-069-136 is the prevention of neutrophil and monocyte adherence to endothelial cells, and s ...

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  7. A rationally-designed, live-attenuated RSV vaccine for the elderly

    SBC: Codagenix Inc.            Topic: NIAID

    PROJECT SUMMARY/ABSTRACT Respiratory syncytial virus (RSV) is a common respiratory virus that usually causes mild, cold-like symptoms. Most people recover within two weeks, but RSV is the most common cause of bronchiolitis and pneumonia in children under one year of age, and leads to hospitalization of ~177,000 adults aged 65 and older of which ~14,000 die annually. Despite many attempts, a vaccin ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Optimization of CXCR1/2 antagonist SX-576 for the treatment of BPD and COPD

    SBC: Syntrix Biosystems, Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): SX-576 is a small molecule CXCR1/2 antagonist that potently blocks the migration of neutrophils to sites of injury and/or inflammation. SX-576 is being developed as a potential therapeutic for the treatment of pulmonaryinflammatory diseases, such as bronchopulmonary dysplasia (BPD) and chronic obstructive pulmonary disease (COPD). In this study, the pharmacokin ...

    SBIR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  9. Human PSMA MAb Radioimmunotherapy for Prostate Cancer

    SBC: PROGENICS PHARMACEUTICALS, INC.            Topic: N/A

    Prostate cancer is the most common cancer of men in the United States with approximately 189,000 new cases and 30,000 deaths in 2002. Recurrent disease can be controlled temporarily with androgen ablation. However, almost all prostate carcinomas eventuall

    SBIR Phase II 2004 Department of Health and Human ServicesNational Institutes of Health
  10. A Vaccine for Schistosomiasis, "SchistoShield"

    SBC: PAI LIFE SCIENCES INC            Topic: NIAID

    DESCRIPTIONprovided by applicantSchistosomiasis is a major neglected tropical disease of public health concern to a billion people withmillion currently infected andmillion at risk to acquire the infectionthe majority of these in AfricaThe disease has a high impact on affected people s lives with disability adjusted life years atmillion years which ran this malady ahead of malariaCurrent control s ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
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