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No other group of diseases encompasses a greater pathophysiology than do the rheumatic diseases Spanning multiple organ systems clinical decisions often rely on coordinated efforts from primary care providers and rheumatologists to rule in or rule out differential diagnoses when treating inflammatory conditions such as rheumatoid arthritis RA and systemic lupus erythematosus SLE RA is a sym ...

Project Summary For modern flow cytometry high throughput multiplexing is extremely important because of the great need in analyzing a large number of biomolecules on and in a single cell The multiplexing performance of flow cytometry is hindered by the probe performance including their fluorescence brightness and emission bandwidth However there is renewed interest and effort to develop high ...

Copy Number Variations CNVs are a common cause of disease in humans As of today CNVs are most often detected using microarrays However microarrays are expensive and are not able to effectively detect CNVs below K bp range This project is designed to detect both point mutations and CNVs in one clinical test without having to utilize microarrays It is our goal to develop an easy to use solu ...

"Deep Learning for standoff detection of Special Nuclear Material (DLeN) applies the same deep learning techniques that allow computers to beat human performance in image recognition and the game of Go to detecting Special Nuclear Material. Spectral analysis and signal processing can in some cases be augmented by the use of much larger neural nets that conduct much deeper analysis of features of t ...

Project Summary Abstract People in all facets of life are exposed to volatile toxins that may cause them to unexplainably sicken The NIEHS Exposure Biology and Exposome Program has the ambitious and worthy goal to track a person s exposures from conception to death and correlate these with biological responses and health outcomes Achieving this goal will require numerous inexpensive sensors that ...

Project Summary Chagas disease is a severe inflammatory syndrome caused by infection with a protozoan parasite Trypanosoma cruzi Although transmission occurs mostly through an intermediate insect host the infection is silent and chronic carriers pose a significant risk through the transfer of infected products made from donated blood of these individuals to blood recipients Up to new c ...

Large scale electrophysiology recordings are recognized as a powerful tool for systems neurobiology and investigation of normal and pathological brain function Buzsaki Continuous high spatial and temporal resolution intracranial electroencephalography iEEG and single neuron recordings from animals and humans are increasingly being used to investigate both normal and pathologic brain f ...

PROJECT SUMMARY The goal this Phase SBIR project is to develop an agonist bias assay for screening drugs that target seven transmembrane G protein coupled receptors GPCRs Phase will establish the feasibility of a robust assay platform to detect when particular GPCR agonists activate both arrestin and G protein pathways This assay will detect responses in living cells on automated fluores ...

We aim to develop a transcranial Doppler TCD ultrasound simulator on a physical mannequin for realistic medical training and professional competence testing The Specific Aims of the project are Develop a prototype TCD simulator The anatomy of the cerebrovascular system CVS will be reconstructed in three dimensional D from a patient s computed tomography angiogram CTA The blood flow ...

PROJECT SUMMARY Improving STEM focused curriculum is a primary objective of the current U S administration and is crucial for ensuring that upcoming generations receive the training and skills necessary to compete in the existing global economy To that end there is an urgent need for additional effective teaching tools able to reach a generation that requires instant access to information and a ...