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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Development of a high-throughput screen to detect the effects of both pre- and post-biotransformed compounds for enhanced content drug discovery workflows

    SBC: 490 BIOTECH INC            Topic: 300

    Development of a high throughput screen to detect the effects of both preand postbiotransformed compounds for enhanced content drug discovery workflows Project Summary This Small Business Innovation Research Phase II project will build upon our successful Phase I demonstration that substrate free autobioluminescent signal generation can detect both the preand post biotransformed metabolic impacts ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Enabling point-of-care molecular diagnostics by developing an adaptive PCR instrument and on-demand kit reagents

    SBC: BIOVENTURES, INC            Topic: 172

    Because of its high sensitivitypolymerase chain reactionPCRis the gold standard for the diagnosis of many infectious diseasesbut generally only implemented in well equipped laboratoriesOne of the major roadblocks for expanding PCR to point of care markets is the lack of simplerobustsingle tube PCR designs which preserve its laboratory based high sensitivity and specificityIn this Fast Track STTR a ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Therapeutic TRPA Mechanism Based Treatment of Chemotherapeutic Induced Neuropathic Pain

    SBC: ALGOMEDIX, INC.            Topic: 102

    Abstract Cancer patients treated with many widely used chemotherapeutic agents including paclitaxel PAC and oxaliplatin OXA frequently develop chemotherapy induced peripheral neuropathy CIPN that may lead to dose reduction dosing schedule changes and termination of treatment In some patients acute peripheral neuropathy PN can transition into chronic PN lasting well beyond termination ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. A Nanopatterned Interdigitated Electrode Array Device for Anti migratory Cancer Drug Screening

    SBC: CURI BIO, INC.            Topic: 102

    PROJECT SUMMARY As the cancer drug industry suffers from the lowest success rate in developing cancer cure drugs cell migration assessment assays that evaluate the transition of cells from a benign to a metastatic phenotype have gained more attention Given the fact that metastatic cancer cells are substantially harder to eradicate than those that are benign migratory propensity is now understoo ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Patient-centered leukemia diagnostic and monitoring using the HemoLink-MD

    SBC: Tasso, Inc            Topic: NCI

    Project Summary There is an urgent unmet need for simplified and improved blood testing systems that can be utilized outside of centralized clinical settingsBlood cancers are a major health problem in the United Statesrepresenting overof all new cancersAcute myeloid leukemiaAMLis a particularly fast evolving form of cancer with low rates of survivalFollow initial therapy treatmentsAML patients mus ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Using Serious STEM Interactive Digital Technology To Understand Agriculture

    SBC: MEADOWLARK SCIENCE AND EDUCATION, LLC            Topic: 500

    PROJECT SUMMARY Improving STEM focused curriculum is a primary objective of the current U S administration and is crucial for ensuring that upcoming generations receive the training and skills necessary to compete in the existing global economy To that end there is an urgent need for additional effective teaching tools able to reach a generation that requires instant access to information and a ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Ultra Bright Fluorescent Probes for Flow Cytometry

    SBC: LAMPROGEN INC            Topic: 100

    Project Summary For modern flow cytometry high throughput multiplexing is extremely important because of the great need in analyzing a large number of biomolecules on and in a single cell The multiplexing performance of flow cytometry is hindered by the probe performance including their fluorescence brightness and emission bandwidth However there is renewed interest and effort to develop high ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Nutritional Therapy in Elderly with Heart Failure

    SBC: Essential Blends, LLC            Topic: NIA

    Project Summary Abstract We have developed a nutritional formulation of amino acids called UpBeat that is designed to promote physical function and quality of life in older individuals with heart failureReduced exercise capacity is a prominent clinical feature of heart failureThis leads to progressive muscle weakness and a vicious cycle of sedentary behaviorweight gainand subsequent development of ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Range Encoded Difference Compression of EEG on a chip for Implantable Devices

    SBC: NEURALYNX INC            Topic: 101

    Large scale electrophysiology recordings are recognized as a powerful tool for systems neurobiology and investigation of normal and pathological brain function Buzsaki Continuous high spatial and temporal resolution intracranial electroencephalography iEEG and single neuron recordings from animals and humans are increasingly being used to investigate both normal and pathologic brain f ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Rational drug selection for Alzheimer s disease using Indicator Cell Assay Platform iCAP

    SBC: PreCyte Inc            Topic: NIA

    Project Summary We are developing a novel tool for disease diagnosis called the indicator cell assay platform iCAP that uses standardized cultured cells as biosensors to detect disease status of patients from blood or cerebral spinal fluid CSF samples Here we propose to establish proof of concept for applying the assay to drug discovery by initiating development of the iCAP for drug selectio ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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