Award Data

PROJECT SUMMARY ABSTRACT Public Health Problem In the U Speople agedyears and older are living with HIV infectionwith approximatelyothers infected but undiagnosedFor most HIV positive individualsavailable treatments can only control HIV infection and delay progression to AIDSHAART has substantial side effects and fails to prevent at leastof patients from developing HIVassociated neurocognitive dis ...

Project Summary Neurological disorders significantly outnumber diseases in other therapeutic areas and are growing in incidence faster than any other disease classesHoweverthe pharmaceutical industry has been unsuccessful in coming up with effective drugsA big factor in these failures has been a lack of adequate model systems for fundamental disease understanding affecting both diagnosis and treat ...

Because of its high sensitivitypolymerase chain reactionPCRis the gold standard for the diagnosis of many infectious diseasesbut generally only implemented in well equipped laboratoriesOne of the major roadblocks for expanding PCR to point of care markets is the lack of simplerobustsingle tube PCR designs which preserve its laboratory based high sensitivity and specificityIn this Fast Track STTR a ...

eSpin Technologies will design the scale up machine to produce novel high performance separator for lithium primary batteries. The process will be developed to produce novel separator and a variants which has the potential of a significantly higher volumetric efficiency for electrolyte storage capacity and kinetics to distribute electrolyte flow within nanoporous channel efficiently. This new sepa ...

AbstractHealthRhythmsIncSubstantial evidence supports the idea that disruptions in the regularity of behavioral routinesorsocial rhythmscan lead to the onset of psychiatric symptoms and full blown episodes via their impact on endogenous circadian rhythms andconversely that stable social routines protect against new mood episodesBased on our conviction that monitoringevaluatingand increasing the re ...

HYPRES proposes to develop wideband analog-to-digital converters (ADCs) using ultrafast superconductor electronics integrated circuit (IC) technology. The objective is to build upon our prior work on superconductor ADCs to achieve higher sampling rate. In addition, we propose to pursue architectural innovations to obtain higher resolution than that which was achieved before at a given sampling rat ...

ABSTRACTThis application is seeking funding specifically for ChemistryManufacturingand ControlCMCof scale up production of long acting atrial natriuretic peptidedANPand its protected graft co polymerPGCexcipient for use in heart failureHFtreatmentThe extrinsic merit of this project will be the availability of cGMP grade PGC for use in prolonging the half life of various peptide drugs that are in p ...

Problem to be SolvedCapecitabine is a widely prescribed and orally available prodrug of the chemotherapeutic agentfluorouracilFUThe principle dose schedule limiting toxicity associated with its use is Hand Foot syndromeHFSand occurs inof patients receiving capecitabineHFS manifests in the hands and feet of patientsand rapidly progresses to painful peelingblisteringand bleeding that commonly requir ...

The overall objective of this project is to advance the development of a clinically usefully multiplex assay todetect biomarkers of radio sensitivity that will identify subsets of prostate cancer patients for whichradiotherapy should be contraindicated This assay will be capable of predicting the risk of developingadverse effects principally urinary morbidity and rectal injury resulting from ...

Our goal is to develop VTC MSas a novel tolerance inducing therapeutic to treat Multiple SclerosisMSMS is the most common demyelinating disorder of the Central Nervous SystemCNSaffecting approximatelymillion people worldwide andin the US aloneCurrent and developing treatment of MS relies mainly on immuno suppression and modulation to reduce inflammatory symptoms creating a significant need for new ...