Award Data

Project Summary Neurological disorders significantly outnumber diseases in other therapeutic areas and are growing in incidence faster than any other disease classesHoweverthe pharmaceutical industry has been unsuccessful in coming up with effective drugsA big factor in these failures has been a lack of adequate model systems for fundamental disease understanding affecting both diagnosis and treat ...

Because of its high sensitivitypolymerase chain reactionPCRis the gold standard for the diagnosis of many infectious diseasesbut generally only implemented in well equipped laboratoriesOne of the major roadblocks for expanding PCR to point of care markets is the lack of simplerobustsingle tube PCR designs which preserve its laboratory based high sensitivity and specificityIn this Fast Track STTR a ...

eSpin Technologies will design the scale up machine to produce novel high performance separator for lithium primary batteries. The process will be developed to produce novel separator and a variants which has the potential of a significantly higher volumetric efficiency for electrolyte storage capacity and kinetics to distribute electrolyte flow within nanoporous channel efficiently. This new sepa ...

DESCRIPTION (provided by applicant): The analysis of cancer within complex heterogeneous tissues represents special challenges posed by the presence of infiltrating non-neoplastic cells. We have developed biolithography, a novel and proprietary met

DESCRIPTION (provided by applicant): Among the many mechanisms by which cancer arises, it is now appreciated that inappropriate phosphorylation is a key pathway. Detection agents capable of binding discrete phosphoproteins with high specificity wil

Optically pumped, high power, mid-Infrared semiconductor lasers that operate at cryogenic temperature must be engineered to operate over large ambient temperature and harsh vibration environments to be able to be used in future IRCM systems. The proposed work will demonstrate novel methods of laser packaging that enable operation of a low cost, mid-infrared, semiconductor laser in military tempe ...

DESCRIPTION (provided by applicant): Antibacterial resistant Staphylococcus aureus, in particular methicillin-resistant S. aureus (MRSA), infections constitute a serious worldwide health problem. MRSA infections are usually hospital-acquired, although the

ABSTRACTThis application is seeking funding specifically for ChemistryManufacturingand ControlCMCof scale up production of long acting atrial natriuretic peptidedANPand its protected graft co polymerPGCexcipient for use in heart failureHFtreatmentThe extrinsic merit of this project will be the availability of cGMP grade PGC for use in prolonging the half life of various peptide drugs that are in p ...

Our goal is to develop VTC MSas a novel tolerance inducing therapeutic to treat Multiple SclerosisMSMS is the most common demyelinating disorder of the Central Nervous SystemCNSaffecting approximatelymillion people worldwide andin the US aloneCurrent and developing treatment of MS relies mainly on immuno suppression and modulation to reduce inflammatory symptoms creating a significant need for new ...

This proposal will create an open speech signal processing platform. The open computational framework will be used for developing algorithms that will help accelerate acoustic and hearing science research. It will permit researchers to more rapidly and easily test new algorithms with greater control, performance, and ease. Several example systems will be created to show that the platform can be ad ...