Award Data

Accurate real-time waterborne pathogen detection is of paramount importance to security of U.S. military forces and installations. Fieldable high-throughput pathogen concentration is a critical analytical need for enhanced detection performance. Existing concentration methods are time-consuming, bulky, labor-intensive, power- and reagent-hungry, and consequently ill-suited for battlefield deployme ...

deciBel Research and our university partner, Rochester Institute of Technology (RIT)-Center for Imaging Science, propose to develop a dual MWIR/LWIR imaging polarimeter for the detection and discrimination of aerosolized biological spores. The system will exploit spectral absorption and MIE scattering-induced radiometric and polarimetric phenomenon exhibited by clouds of aerosolized biological spo ...

Highly scalable parallel random number generators (RNGs) will be developed, evaluated and implemented for use in high performance computing on thousands of multi-core processors and general purpose graphics processing units. The main contributions are: (a) design and implementation of new parallel test methods that capture the inter-stream correlations exhibited in practice and complement the curr ...

Sensor development researchers and engineers have perpetually sought novel methods to reduce sensor size and improve performance. Continued miniaturization of sensors through micromachining has enabled novel applications and introduced new paradigms for engineered systems to interact with the world. The challenge has always been to improve performance while continually reducing size. In the cur ...

DESCRIPTION (provided by applicant): Advanced Medical Electronics Corp, in collaboration with the Johns Hopkins University School of Medicine, proposes to develop a hardware/software platform suitable for administering a variety of tests and survey instruments to underserved populations in settings that can range from living rooms to libraries, community centers to nursing homes, and from inner ci ...

DESCRIPTION (provided by applicant): This proposal involves the development and validation of a novel approach to improve and accelerate the discovery of biopharmaceuticals (i.e. vaccines, monoclonal antibodies and other therapeutic proteins). Biopharmaceuticals are used to treat a variety of infectious and chronic diseases. The proposed research is intended to establish a new paradigm for rapidly ...

DESCRIPTION (provided by applicant): Crystallization, followed by subsequent structure determination, is a major step in understanding the structure-function relationship of macromolecules. Understanding macromolecule structure has become a key part in the development of new pharmaceuticals, and is a major area of NIH research. Crystallization however is also the rate limiting step, despite techn ...

DESCRIPTION (provided by applicant): This STTR application is to develop and test for eventual clinical use a new strategy for tumor specific anticancer drug delivery. The technology, Clostridia-directed enzyme prodrug therapy, or CDEPT, exploits the fact that certain non-pathogenic bacteria of the Clostridia genus, which only grow in the absence of oxygen (hypoxia), colonize the hypoxic and necr ...

DESCRIPTION (provided by applicant): It is uniformly recognized that sedentariness - the sitting disease - is bad for the health of the nation. The solution to reversing sedentariness involves devising and disseminating real-world solutions to promote day-long physical activity and help people who want to, to lose weight and improve their blood glucose, lipids and blood pressure. The Gruve is ...