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Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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Tumor Antigen Targeted Nanoparticle Therapy for Glioblastoma (GBM)
SBC: NANOVALENT PHARMACEUTICALS INC Topic: 102Project Summary The goal of this Fast Track STTR project is to determine proof-of-principle and efficacy of a novel blood brain barrier (BBB) penetrating therapeutic nanoparticle for the potential treatment of otherwise intractable brain tumors like glioblastoma multiforme (GBM). This project seeks to demonstrate that novel, targetable nanoparticles can delivery therapeutic substances to human bra ...
STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Pharmacogenomics Workflow: Identifying Biomarkers and Treatment Options
SBC: Golden Helix, Inc. Topic: 172Abstract Pharmacogenomics, the study of how an individual's genetic makeup affects their response to drugs, has undergone rapid advancements. This has occurred alongside a decrease in the cost of genotyping technology, making implementation of pharmacogenomics into clinical practice increasingly feasible. Personalized medicine leveraging pharmacogenomics is gaining momentum to optimize drug choice ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Selective CYP26 inhibitors for the oral treatment of recalcitrant nodular acne.
SBC: DERMAXON LLC Topic: NIAMSProject Summary / Abstract DermaXon's project goal is to develop efficacious, substrate-based, selective inhibitors of CYP26s, the enzymes responsible for the metabolism of all-trans retinoic acid (atRA) in the epidermis, as an oral treatment for severe recalcitrant acne. This approach will provide an improved acne therapeutic without the adverse effects associated with currently marketed retinoid ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
A Simple at-home test for rapid and accurate screening for Hepatitis C Virus (HCV) exposure
SBC: PATHOVACS INCORPORATED Topic: 441Development and feasibility demonstration of a prototype rapid and accurate Lateral Flow Assay (LFA) to self-screen qualitatively for exposure to Hepatitis C Virus (HCV) in at-home settings, is proposed. The LFA, employing conserved immunogenic domains of proteins comprising the HCV human immunoproteome, will detect host antibody responses to such immunogenic protein domains in user-generated fing ...
SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health -
Preclinical evaluation of HIV-1 envelope immunogens in humanized mice
SBC: NEOVAXSYN INC Topic: 102Genetically Engineered Mice for Pre-clinical Evaluation of HIV Vaccine Candidates: The development of novel HIV candidate vaccines generally requires preclinical testing in animal models before proceeding to Phase I clinical trials. Multiple efforts have focused on developing and evaluating innovative platforms and formulations of HIV envelope (Env) immunogens for the induction and generation of a ...
SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health -
Booth™ by Opio™: Developing technology to expand the reach of opioid treatment programs into rural and underserved areas.
SBC: Opio Connect, Inc. Topic: NIDAThe goal of this project is to develop a treatment booth with technology that allows opioid treatment programs to remotely dispense, either methadone or buprenorphine, under medical observation through telemedicine to a patient in a treatment booth. We believe that robotic automation is the ideal application to perform the same mechanical functions of the nurse at the dosing window. Specifically, ...
SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health -
Wastewater data integration and modelling to accurately predict community and organizational outbreaks due to viral pathogens
SBC: SUPERIOR STATISTICAL RESEARCH LLC Topic: NIAIDProject Summary. The COVID-19 pandemic has magnified the need for enhanced ability to accurately anticipate future outbreaks due to novel and endemic viral pathogens. Without systematic surveillance, the ability to head off outbreaks before they occur is challenging: the data from positive human test results is often too late to prevent a major outbreak from occurring, despite substantial lockdown ...
SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health -
Development of Machine Learning Composite Measures for Graft Outcome Selection in Pediatric Liver Transplantation
SBC: Healthtech Solutions, Inc. Topic: 300ABSTRACT Outcomes in pediatric liver transplantation (pLT) are not limited by the donated organ supply. Kids are dying waiting for organs even when these deaths are completely preventable through proper organ selection. Instead of dying, children can live a full and active lifetime with a properly selected liver graft for transplant. Critical to achieving zero waitlist mortality and long-term tran ...
SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health -
A Saliva Based Epigenetic Assay for Assessing Vitamin B9 and B12 Status
SBC: BEHAVIORAL DIAGNOSTICS, INC. Topic: NIAGene-diet interactions can have major effects on human development, aging and response to medical therapy. In particular, this is true for key nutrients such as Vitamin A, D, B9 and B12. Unfortunately, the current “one size fits all” approaches for determining whether an individual has adequate levels of these and other micronutrients relies on older studies that use serum assays that only cap ...
SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health -
Induction of bnAbs against HIV-1 gp41.
SBC: NEOVAXSYN INC Topic: 105PROJECT SUMMARY/ABSTRACTDespite the availability of effective anti-retroviral drugs, there are still about 38 million people living with HIV-1 infection and about 1.5 million people became newly infected just in 2020. A vaccine is critically needed to stop the AIDS pandemic. Induction of broadly neutralizing antibodies (bnAbs) against HIV-1 is the utmost critical goal towards the development of a ...
SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health