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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Pharmacogenomics Workflow: Identifying Biomarkers and Treatment Options

    SBC: Golden Helix, Inc.            Topic: 172

    Abstract Pharmacogenomics, the study of how an individual's genetic makeup affects their response to drugs, has undergone rapid advancements. This has occurred alongside a decrease in the cost of genotyping technology, making implementation of pharmacogenomics into clinical practice increasingly feasible. Personalized medicine leveraging pharmacogenomics is gaining momentum to optimize drug choice ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Selective CYP26 inhibitors for the oral treatment of recalcitrant nodular acne.

    SBC: DERMAXON LLC            Topic: NIAMS

    Project Summary / Abstract DermaXon's project goal is to develop efficacious, substrate-based, selective inhibitors of CYP26s, the enzymes responsible for the metabolism of all-trans retinoic acid (atRA) in the epidermis, as an oral treatment for severe recalcitrant acne. This approach will provide an improved acne therapeutic without the adverse effects associated with currently marketed retinoid ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Booth™ by Opio™: Developing technology to expand the reach of opioid treatment programs into rural and underserved areas.

    SBC: Opio Connect, Inc.            Topic: NIDA

    The goal of this project is to develop a treatment booth with technology that allows opioid treatment programs to remotely dispense, either methadone or buprenorphine, under medical observation through telemedicine to a patient in a treatment booth. We believe that robotic automation is the ideal application to perform the same mechanical functions of the nurse at the dosing window. Specifically, ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  4. SBIR Phase I: The early detection of HLB Disease in citrus trees utilizing a novel isothermal PCR technology to identify host small RNAs

    SBC: FYR Diagnostics, LLC            Topic: BT

    The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to provide a quick, cost-effective, and sensitive early detection assay for Huanglongbing (HLB) disease (aka citrus greening disease) to guide management strategies and limit its spread. HLB is the most impactful and devastating disease plaguing the global citrus industry. Current diagnosti ...

    SBIR Phase I 2021 National Science Foundation
  5. SBIR Phase I: An Artificial Intelligence-Inspired Computing Application for Detecting the Early Onset of Pneumonia (COVID-19)

    SBC: IMMERSIVE REALITY GROUP LLC            Topic: DH

    The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to develop a Human-Artificial Intelligence (AI) computing application for detecting the early onset of pneumonia. It can be particularly useful for complications of COVID-19; clinical studies have identified a significant association between COVID-19 and pneumonia, with studies observing up ...

    SBIR Phase I 2021 National Science Foundation
  6. Development of a commercial assay for the rapid and general detection of PFAS in environmental matrices (Phase I)

    SBC: WEAVER LABS LLC            Topic: R

    AbstractPolyfluoro- and perfluoroalkyl substances (PFAS) are a group of highly fluorinated alkanes. Members of this family are known to be persistent and bioaccumulative. PFAS are associated with unfavorable health outcomes in human and animal models. Several public health agencies as well as scientists have published articles that indicate the presence of PFAS in human blood, serum, milk, cord bl ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Crosslinkable Tissue Particles for Regenerating Craniofacial Bone in an Ovine Model

    SBC: Leefa Biotech LLC            Topic: NIDCR

    PROJECT SUMMARY The overall goal of this application is the translation of a new crosslinkable bone void filler that will allow surgeons to better heal patients after craniofacial bone loss. The bone void filler designed is unique in that it can be implanted as a paste then quickly transition to a solid after initiation with blue light. The ability to transition into a solid after placement is uni ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  8. PCR-based miRNA assessment of neonatal opioid withdrawal syndrome (NOWS) severity

    SBC: FYR Diagnostics, LLC            Topic: NIDA

    Abstract Opioid use disorder (OUD) has become a national crisis, affecting over 2 million Americans. The number of pregnant women with OUD in the U.S. increased almost 5-fold in the past decade, leading to a similar surge in infants born with neonatal opioid withdrawal syndrome (NOWS), from 1.5 to 8 per 1,000 hospital births (32,000 cases total) between 2004 and 2014. Associated hospital costs hav ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Development of high affinity novel Fluor Mop adsorbent for the rapid removal of perfluorinated chemicals from groundwater

    SBC: WEAVER LABS LLC            Topic: R

    Perfluorinated alkyl substances (PFAS), nicknamed “Forever Chemicals”, are extensively used in industries and firefighting applications as a component of aqueous film forming foams (AFFFs). Because members of this class of chemicals are persistent, they are prevalent in nature and are detected across the globe in water, air, soil, plants, animals, and even in human milk and blood. They are tox ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. A Novel Small Molecule for The Prevention and Treatment of Age-Related Macular Degeneration

    SBC: EXCITANT THERAPEUTICS LLC            Topic: NEI

    SUMMARY Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly in the U.S. Wet AMD accounts for up to 90% of vision loss in AMD patients, which is characterized by choroidal neovascularization (CNV). Currently, no cure exists for AMD, and available drug therapies focus on intravitreal injection of anti- vascular endothelial growth factor (VEGF) agents. These anti-V ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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