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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Pharmacogenomics Workflow: Identifying Biomarkers and Treatment Options

    SBC: Golden Helix, Inc.            Topic: 172

    Abstract Pharmacogenomics, the study of how an individual's genetic makeup affects their response to drugs, has undergone rapid advancements. This has occurred alongside a decrease in the cost of genotyping technology, making implementation of pharmacogenomics into clinical practice increasingly feasible. Personalized medicine leveraging pharmacogenomics is gaining momentum to optimize drug choice ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Selective CYP26 inhibitors for the oral treatment of recalcitrant nodular acne.

    SBC: DERMAXON LLC            Topic: NIAMS

    Project Summary / Abstract DermaXon's project goal is to develop efficacious, substrate-based, selective inhibitors of CYP26s, the enzymes responsible for the metabolism of all-trans retinoic acid (atRA) in the epidermis, as an oral treatment for severe recalcitrant acne. This approach will provide an improved acne therapeutic without the adverse effects associated with currently marketed retinoid ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. LPD & LPI Ultra-low SWaP-C Mesh Networking For Secure Communications In Near-peer Contested Environments

    SBC: BEARTOOTH RADIO, INC.            Topic: AFX235CSO1

      Mission success in contingency operations depends on communication and Beartooth Radio provides a solution when traditional comms are degraded; saving lives by reducing much-needed time battle-tracking friendlies and engaging the enemy when and where it

    SBIR Phase I 2023 Department of DefenseAir Force
  4. Booth™ by Opio™: Developing technology to expand the reach of opioid treatment programs into rural and underserved areas.

    SBC: Opio Connect, Inc.            Topic: NIDA

    The goal of this project is to develop a treatment booth with technology that allows opioid treatment programs to remotely dispense, either methadone or buprenorphine, under medical observation through telemedicine to a patient in a treatment booth. We believe that robotic automation is the ideal application to perform the same mechanical functions of the nurse at the dosing window. Specifically, ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. Innovative Spray Drying Technology for scaling up nano powder production

    SBC: DIVISION BY ZERO DEVELOPMENT LABS LLC            Topic: AF211CSO1

    Division by Zero Labs is a process development lab and engineering firm that specializes in advanced spray drying technologies (method of producing a dry powder from a liquid or slurry by rapidly drying with a hot gas). We perform testing, formulation, method development, design and engineering for spray drying processes and spray drying plants. In doing so we have gained diverse experience across ...

    SBIR Phase I 2021 Department of DefenseAir Force
  6. PCR-based miRNA assessment of neonatal opioid withdrawal syndrome (NOWS) severity

    SBC: FYR Diagnostics, LLC            Topic: NIDA

    Abstract Opioid use disorder (OUD) has become a national crisis, affecting over 2 million Americans. The number of pregnant women with OUD in the U.S. increased almost 5-fold in the past decade, leading to a similar surge in infants born with neonatal opioid withdrawal syndrome (NOWS), from 1.5 to 8 per 1,000 hospital births (32,000 cases total) between 2004 and 2014. Associated hospital costs hav ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Open Call for Innovative Defense-Related Dual-Purpose Technologies/Solutions with a Clear Air Force Stakeholder Need

    SBC: ADELOS, INC            Topic: AF193CSO1

    Adelos, Inc. has developed a commercial, ground-based fiber optic sensor for oil and gas pipeline leak detection and right of way intrusion monitoring using specialized optical microphonic amplification and neural net classification: Phosonic. The US Air Force (AF) has identified a need for a Ground Based Threat Detection Threat System (GBTDS) to detect vehicle and human targets up to 150 meters a ...

    SBIR Phase I 2020 Department of DefenseAir Force
  8. Discovery of NaV1.7 Inhibitors for the Treatment of Pain

    SBC: SITEONE THERAPEUTICS, INC.            Topic: 105

    PROJECT SUMMARY The objective of our program is to develop a safe and effective nonopioid analgesic for the treatment of neuropathic pain, such as pain associated with chemotherapy-induced peripheral neuropathy, that targets an isoform of the voltage-gated sodium ion channel, NaV1.7. Voltage-gated sodium channels are involved in the transmission of nociceptive signals from their site of origin in ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Acoustic Enhanced Cell Culture

    SBC: RESODYN CORPORATION            Topic: 400

    This Small Business Innovation Research Phase I project will develop a prototype and then evaluate a novel device that utilizes low frequency sound energy to enhance cell culture productivityThe acoustic micromixing generated by the proposed device is compatible with cells and possesses the capability to substantially enhance the culture efficiency of cells cultured in typical culture vesselsThis ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Development of NaV1.7 Inhibitors for the Treatment of Chronic Cough

    SBC: SITEONE THERAPEUTICS, INC.            Topic: NHLBI

    PROJECT SUMMARYThe objective of our program is to develop a safe and effective therapeutic for chronic coughChronic coughor cough that persists for more than eight weeksis a condition that is often associated with diseases such as chronic obstructive pulmonary disorderCOPDasthmaidiopathic pulmonary fibrosisbronchiectasis or gastroesophageal reflux diseaseGERDIn other casesthe etiology is unknownCh ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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