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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Harmony AI: State of the Art Natural Language Processing for Genetic Engineering

    SBC: CFD RESEARCH CORPORATION            Topic: 400

    Project Summary/Abstract: Computational techniques for gene engineering, such as codon optimization, use synonymous codon changes to increase protein production. Applications for these computational gene optimizations include recombinant protein drugs, nucleic acid therapies, and mRNA vaccines. Although codon optimization increases protein production in certain systems, synonymous changes to a gen ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Harmony AI: Natural Language Processing Enabling Advanced Biomanufacturing

    SBC: CFD RESEARCH CORPORATION            Topic: 400

    Project Summary/Abstract: Recombinant proteins have a wide range of applications, from pharmaceutical products, drug discovery, protein-based polymers for drug delivery, antibodies enzymes, and sustainable technologies such as textiles and vegan food production such as the impossible burger. Towards meeting these increased demands by replacing batch culture with continuous culture reduces overhead ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Pharmacogenomics Workflow: Identifying Biomarkers and Treatment Options

    SBC: Golden Helix, Inc.            Topic: 172

    Abstract Pharmacogenomics, the study of how an individual's genetic makeup affects their response to drugs, has undergone rapid advancements. This has occurred alongside a decrease in the cost of genotyping technology, making implementation of pharmacogenomics into clinical practice increasingly feasible. Personalized medicine leveraging pharmacogenomics is gaining momentum to optimize drug choice ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Bionanomatrix coating to enhance antibacterial effects while reducing inflammation of knee joint implants

    SBC: ENDOMIMETICS LLC            Topic: NIAMS

    Osteoarthritis (OA) is a degenerative joint disease that affects over 32 million individuals in the United States, causing debilitating joint destruction and chronic joint pain, stiffness, and physical impairment. To restore and improve the patient’s quality of life, total knee arthroplasty (TKA) is the most common surgical intervention performed for OA to replace the compromised joint with arti ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Selective CYP26 inhibitors for the oral treatment of recalcitrant nodular acne.

    SBC: DERMAXON LLC            Topic: NIAMS

    Project Summary / Abstract DermaXon's project goal is to develop efficacious, substrate-based, selective inhibitors of CYP26s, the enzymes responsible for the metabolism of all-trans retinoic acid (atRA) in the epidermis, as an oral treatment for severe recalcitrant acne. This approach will provide an improved acne therapeutic without the adverse effects associated with currently marketed retinoid ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. An Inhaled Microbiome-Targeted Biotherapeutic for Treatment of COPD

    SBC: ALVEOLUS BIO, INC.            Topic: NHLBI

    PROJECT SUMMARY - ResBiotic Inc. is developing its lead drug product, RB1000, a spray-dried powder com- prised of an inhaled biotherapeutic API for treatment of neutrophilic inflammation and disease progression in COPD patients. COPD is a chronic degenerative disease that is the fourth leading cause of death in the U.S., where it predominantly results from tobacco smoke exposure. Acute exacerbatio ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Low SWaP Tactical Ultra-Secure Communications System

    SBC: IERUS TECHNOLOGIES INC            Topic: SOCOM221001

    When there is a contested environment, and SOCOM needs no-compromise ultra-secure communications, the IERUS Technologies Low-SWaP Ultra-Secure Tactical OTM Communication System (LUTOCS) is there. Utilizing an open agile architecture based on software defined radio (SDR) technology to implement advanced software and hardware solutions, the system is tailored for optimal performance in dynamic situa ...

    SBIR Phase I 2022 Department of DefenseSpecial Operations Command
  8. Development of AS01b Mimics by Replacing QS-21 with a New Saponin Adjuvant

    SBC: Adjuvax LLC            Topic: 106

    AS01b (composed of the molecules QS-21 and MPL) is a powerful adjuvant best known for being a component of the FDA-approved Shingrix vaccine. Despite its successful track-record as an effective adjuvant, accessibility to AS01b as an adjuvant for use in novel vaccines is a concern due to the limited nature of the saponin molecule QS-21. The awardee seeks to address this problem by developing a mimi ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. OPTIMIZE FORMULATION OF VSA ADJUVANT

    SBC: Adjuvax LLC            Topic: 105

    The contract supports the development of a saponin as a vaccine adjuvant. The adjuvant development activities are being conducted within the context of vaccines to protect against SARS-CoV-2 and pneumococcal infection.

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  10. Solid State High Energy Desity Batteries

    SBC: CFD RESEARCH CORPORATION            Topic: SOCOM222001

    The modern warfare environment has demonstrated an ever-increasing need for electrical power and energy carrying capacity. Soldiers are now expected to carry in excess of 20lbs of batteries for a 72-hour mission. This weight only increases when operating specialized equipment such as communication, targeting, or mobility equipment. As a consequence, lithium-ion (Li-ion) battery packs have become t ...

    SBIR Phase I 2022 Department of DefenseSpecial Operations Command
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