Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. TOPIC 389- INTELLIGENT SOFTWARE FOR RADIATION THERAPY PLANNING

    SBC: RadiaSoft LLC            Topic: NCI

    Besides surgeryradiotherapy is the most effective treatment modality for localized prostate cancerThe success of radiotherapy stems from the exploit of a therapeutic window in tumor response and normal tissue tolerance which maximizes the chance of sterilizing the tumor while sparing the surrounding normal tissue from severe damageThis requires an accurate and individualized radiation dose distrib ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Bioinformatic Tools for Interpretation of Glycan Array Data

    SBC: Z Biotech, LLC            Topic: 400

    Project SummaryAbstract There is an urgent need of bioinformatic tools for mining glycan array data in order to accurately and statistically study the interactions between cell surface glycans and glycan binding proteinsWe propose here to develop a software and hardware integrated system for the interpretation of glycan array dataThe problem with existing glycan array data mining tools is that the ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Organic photoredox catalysts as sustainable and cost-effective replacement for precious metal complexes in light-driven drug synthesis

    SBC: New Iridium Inc            Topic: 300

    PROJECT SUMMARYLight driven chemistryor photoredox catalysishas made significant advances in the last decade for practical organic or drug synthesisFor examplelight induced reactions have enabled generation of radical intermediate Rfor direct functionalization of biologically relevant heterocycles and cross coupling reactions for important covalent bond formationsThereforephotoredox catalysis offe ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Discovery of NaV1.7 Inhibitors for the Treatment of Pain

    SBC: Siteone Therapeutics, Inc.            Topic: 105

    PROJECT SUMMARY The objective of our program is to develop a safe and effective nonopioid analgesic for the treatment of neuropathic painsuch as pain associated with chemotherapy induced peripheral neuropathythat targets an isoform of the voltage gated sodium ion channelNaVVoltage gated sodium channels are involved in the transmission of nociceptive signals from their site of origin in the periphe ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Human Milk Concentration Device; Point of Care Technology for Feeding Preterm Infants in Intensive Care

    SBC: MOTHER'S MILK IS BEST, INC.            Topic: NICHD

    Human milk is the best feeding option for preterm infantsHoweverdue to the high nutrient needs of preterm infants in US Neonatal Intensive Care UnitsNICUsthe mother s own milk is most often mixed with bovine milk sourced fortifiers to achieve goal nutrient levelsThe Human Milk ConcentrationHMCdevice concentrates a mother s milk by removing water so that preterm infants can receive adequate nutrien ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. A compact, modular two-photon fiber-coupled microscope for in vivo all-optical electrophysiology

    SBC: INTELLIGENT IMAGING INNOVATIONS, INC.            Topic: 101

    Good methods to interrogateand ideally perturbneural systems at the network level have been elusive until recentlyThe advent of biochemical breakthroughsnamely neuronally targeted genetically encoded calcium reporterssuch as GCaMPand light activated channelssuch as channelrhodopsinhave enabledall opticalelectrophysiology where experiments can be conducted that involve simultaneousor closely sequen ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Acoustic Enhanced Cell Culture

    SBC: RESODYN CORPORATION            Topic: 400

    This Small Business Innovation Research Phase I project will develop a prototype and then evaluate a novel device that utilizes low frequency sound energy to enhance cell culture productivityThe acoustic micromixing generated by the proposed device is compatible with cells and possesses the capability to substantially enhance the culture efficiency of cells cultured in typical culture vesselsThis ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Development of NaV1.7 Inhibitors for the Treatment of Chronic Cough

    SBC: Siteone Therapeutics, Inc.            Topic: NHLBI

    PROJECT SUMMARYThe objective of our program is to develop a safe and effective therapeutic for chronic coughChronic coughor cough that persists for more than eight weeksis a condition that is often associated with diseases such as chronic obstructive pulmonary disorderCOPDasthmaidiopathic pulmonary fibrosisbronchiectasis or gastroesophageal reflux diseaseGERDIn other casesthe etiology is unknownCh ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. A wearable high-density MEG system with uOPMs

    SBC: FieldLine Inc.            Topic: 101

    Abstract This Phase I project will focus on developing key elements needed to achieve a wearablehigh densitymagnetoencephalographyMEGdevice based on optically pumped atomic magnetometersOPMsOPM sensors have progressed to be comparable in sensitivity to liquid helium cooled superconducting sensorsSQUIDsbut without the complexity and bulk required by cryogenic coolingAn OPM based MEG provides furthe ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Reference standards for quality control and data validation in microbiome studies

    SBC: Biocollective, LLC, The            Topic: 400

    Contact PD PICanoRaul JCompanyThe BioCollectiveLLCApplication IdentifierFOAPASUMMARY Significant advances in high throughput sequencing and new tools for analyzing microbiomes as well as the demonstrated value of microbiome research in human health are driving rapid development in this fieldThis rapid and exponential increase in microbiome related studieshoweveremploys a stochasticnon standardized ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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