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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Developing an integrated pipeline for routine generation of orthogonal GPCR-targeting nanobodies

    SBC: VITAN-BIOTECH LLC            Topic: 300

    Project SummaryA broad range of neurological indications, including schizophrenia, pain, Parkinson's and Alzheimer's diseases, and autism have been linked to G-protein coupled receptor proteins (GPCRs), making them attractive targets for therapy. Understanding GPCR dysfunction is essential for effective therapeutic development. However, deciphering the functions of GPCRs remains a daunting task in ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Advanced Pediatric Airway Trainer for Enhanced Clinical Education in Pediatric Critical Care

    SBC: TDA RESEARCH, INC.            Topic: NICHD

    Project Summary/Abstract Clinical training aids such as surgical mannequins and procedural trainers are important tools for teaching proper technique to physicians and first responders. However, the majority of these training tools were developed for adult anatomies. Pediatric patients are often more challenging to treat, but few resources exist for advanced simulation in pediatric critical care e ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Development of an AI-empowered device that utilizes multimodal data-visualization to aid in the diagnosis, and treatment, of OUD

    SBC: WAVi Co.            Topic: NIDA

    Abstract Assessing the effectiveness of opioid use disorder (OUD), where high relapse rates create financial and social tolls, is a pressing clinical problem in need of better measurement tools. The ability to identify cognitive changes should improve outcomes but current intake into rehabilitation programs doesn’t typically include cognitive tests. Simple, quick, cost-effective, and objective m ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Topical Drug Delivery System as an Anti-Inflammatory and Pro-Angiogenic Therapy for Diabetic Wound Healing

    SBC: GELSANA THERAPEUTICS INC            Topic: 200

    SUMMARY Impaired wound healing in diabetic patients represents a major clinical problem, resulting in prolonged hospitalizations and significant healthcare expenditures. The financial burden of this is extreme, representing $78 billion annually in the U.S. alone. Two-thirds of all non-traumatic amputations are preceded by a diabetic wound, and every 20 seconds a lower limb is lost to a diabetic wo ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Flu Vaccine Production Using a Novel Pandemic Response and Prevention Manufacturing Method

    SBC: SOLARIS VACCINES, INC.            Topic: NIAID

    PROJECT SUMMARY/ABSTRACT The current global pandemic has highlighted the need to develop new methods for creating vaccines. Many approaches today face limitations with breadth and duration of protection; flexibility and adaptability for emerging strains; manufacturing speed and safety; and storage and distribution. SolaVAX™ inactivation technology offers an elegant solution for quickly generatin ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Strep-CaDI: A fast, accurate, and sensitive point-of-care test for Group A Streptococcus

    SBC: BURST DIAGNOSTICS INC            Topic: NIAID

    SUMMARY The current rapid antigen detection tests for group A strep lack sensitivity and result in upwards of 10 million unnecessary antibiotic treatments provided to children each year. Current diagnostic methods utilized when a patient presents at a clinic with a sore throat include a throat swab and rapid strep test. A positive rapid test results in antibiotic prescription, but due to the low s ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Leveraging Label-Free Digital Imaging to Enable Rapid On-Site Evaluation (ROSE) During Thyroid Biopsy Procedures

    SBC: PATHWARE INC.            Topic: 102

    Project Summary/Abstract Pathware is developing Bioptic™, an imaging platform to analyze biopsy samples at the point-of-care. The system will rapidly digitize unstained biopsy samples and utilize computer-aided detection/diagnostics to enable quick and efficient evaluations by pathologists. Typical barriers to point-of-care diagnostics are overcome by combining novel computational microscopy wit ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  8. A Novel Small Molecule Therapeutic for Acute Graft Versus Host Disease

    SBC: CRESTONE, INC.            Topic: NIAID

    ABSTRACT Allogeneic hematopoietic cell transplantation (allo-HSCT) is an effective therapy for a number of malignant and non- malignant blood and metabolic diseases, but its applicability has been limited by graft-versus-host disease (GvHD). GvHD is responsible for 15-30% of deaths that occur following HSCT and is the main cause of morbidity in up to 50% of recipients. Current prevention and treat ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. A ratcheting pediatric prosthetic finger using advanced rapid manufacturing technology

    SBC: POINT DESIGNS, LLC            Topic: NICHD

    A ratcheting pediatric prosthetic finger using advancedrapid manufacturing technology ABSTRACT The goal of the proposed project is to develop and commercialize a purely mechanical, ratcheting pediatric prosthetic finger – the Point Mini – which 1) has an industry leading strength to weight ratio, 2) can be operated unilaterally (one-handed), 3) offers anatomical rotation and flexion around the ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  10. High-resolution extended-depth phase-engineered objectives to accelerate spatial 'omics RandD through computational optics

    SBC: Double Helix Optics Inc            Topic: 400

    Summary This SBIR Phase I project is focused on the design, development, and testing of groundbreaking engineered point spread function (ePSF) objective lenses, and matched computational algorithms for spatial omics research and development, which will be suitable for fixed and live-cell applications and will enable breakthroughs in fast live-cell spatial omics RandD by increasing the depth of fie ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
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