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THE AIM OF THIS PROPOSAL IS THE ADAPTATION OF BACULOVIRUS FOR THE PRODUCTION OF SYNTHETIC VACCINES. LATE AFTER INFECTION, BACULOVIRUS-INFECTED CELLS PRODUCE PARACRYSTALLINE OCCLUSION BODIES THAT CONSIST PRIMARILY OF ASINGLE PROTEIN, POLYHEDRIN. AMERICAN BIOGENETIC SCIENCES, INC. INTENDS TO MODIFY THE POLYHEDRIN GENE OF AUTOGRAPHA CALIFORNICA TO GENERATE RECOMBINANT OCCULSION BODIES EXPOSING ANTIGE ...

ASH MEDICAL SYSTEMS, INC. HAS DEVELOPED A NEW SORBENT-BASED,SINGLE-ACCESS HEMODIALYSIS MACHINE THAT IS SAFE, SIMPLE, AND PORTABLE. THE BIOLOGIC-HD CURRENTLY USES A PLATE DIALYZER TO ACTIVELY PUMP BLOOD WHILE DIALYZING THE BLOOD AND A REDY HISORB COLUMN TO REGENERATE DIALYSATE. PREVIOUS RESEARCH HAS PROVEN THAT A THICK SORBENT SUSPENSION CAN FLOWTHROUGH THE SCREEN SUPPORTS OF THE PLATE DIALYZER, RE ...

EFFECTIVE HEMODIALYSIS REQUIRES A BLOOD FLOW OF 250 TO 300 ML/MINUTE. THE USUAL METHOD FOR OBTAINING THIS BLOOD ISTO PLACE TWO LARGE NEEDLES INTO A FISTULA (ARTERIALIZED VEIN) OR A GRAFT (PTFE CONDUIT BETWEEN ARTERY AND VEIN). BOTH NEEDLES ARE REMOVED AT THE END OF EACH TREATMENT. THE OBJECTIVE OF THIS PROPOSAL IS TO FURTHER DEVELOP AN INDWELLING FISTULA ACCESS DEVICE (IFAD) THAT CAN BE INSERTEDIN ...

THE AUDIO MECHANICAL TRANSDUCER (AMT) COMMUNICATION SYSTEM WILL SIGNIFICANTLY IMPROVE THE ENVIRONMENT OF WORKERS IN HIGH-AMBIENT-NOISE CONDITIONS BY PROVIDING A NEW METHOD OF COMMUNICATING. THE SYSTEM WILL ATTACH DIRECTLY TO MOST FORMS OF HEARING PROTECTION WITHOUT MODIFICATION OF THE PROTECTOR. IT WILL BE LOW COST, PERMIT MULTIPLE AUDIO INPUTS, AND DEMONSTRATE MAN/MACHINE INTERFACE CAPABILITIES. ...

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THIS PROJECT INTENDS TO STUDY THE FEASIBILITY OF DEVELOPING ANALYTICAL PROCEDURES TO BE USED FOR IDENTIFYING THE COUNTRYOF ORIGIN OF A GIVEN CANNABIS SAMPLE ON THE BASIS OF ITS CHEMICAL PROFILE. GAS CHROMATOGRAPHY/MASS SPECTROMETRY (GC/MS) WILL BE THE MAIN TECHNIQUE USED IN THE DEVELOPMENT OF SUCH PROCEDURES. BOTH UNDERIVATIZED AND DERIVATIZED CANNABIS EXTRACTS FROM MULTIPLE SAMPLES FROM EACH COUN ...

RECENT TECHNICAL ADVANCEMENTS IN THE SEMICONDUCTOR DEVICE AND POWER CONDITIONING TECHNOLOGIES HAVE LED TO SUBSTANTIAL IMPROVEMENTS IN TERMS OF SIZE, WEIGHT, EFFICIENCY AND POWER QUALITY OF THE POWER CONDITIONING EQUIPMENT WHICH IS BEING CONSIDERED FOR SPACE APPLICATIONS. WITH THESE ADVANCEMENTS COMES AN ABUNDANCE OF DESIGN CHOICES AND INCREASED DEGREES OF FREEDOM WITH RESPECT TO POWER SYSTEM CONTR ...

ONE PROMISING APPROACH TO THE DEVELOPMENT OF GENERALIZED MODELS OF COMMUNICATION SYSTEMS IS COMPOSITION OF MODELS FROM COMPONENT MODEL MODULES. IN THIS APPROACH, MODELS OF INDIVIDUAL SYSTEM COMPONENTS ARE DEVELOPED AND SUBSEQUENTLY LINKED INTO A MODEL BY MODEL COMPOSITION SOFTWARE. AN INTEGRATED SOFTWARE ENVIRONMENT SUPPORTS THIS TECHNOLOGY BY MANAGING A MODELBASE OF MODEL MODULES PROVIDING FOR TH ...

THIS PROJECT IS DIRECTED TOWARD DEVELOPMENT AND TESTING OF A LIPOSOMAL ADJUVANT SYSTEM THAT WILL ENGENDER A STRONG AND SUSTAINED IMMUNE RESPONSE TO ANTIGENS OF LOW IMMUNOGENICITY. THIS ADJUVANT SYSTEM WILL CONSIST OF LIPOSOMES THAT CONTAIN ONE OR MORE NONTOXIC IMMUNOPOTENTIATORS OF MICROBIAL OR SYNTHETIC ORIGIN. THESE IMMUNOPOTENTIATORS ARE HIGHLY ACTIVE AS ADJUVANTS WHEN ADMINISTERED IN OIL-IN-WA ...

FEASIBILITY RESEARCH IS PROPOSED FOR THE DEVELOPMENT OF A COMPUTER-BASED EXPERT RADIOLOGY ASSISTANT (XRA) TO AID IN THE DIAGNOSIS OF BREAST CANCER. THE PROPOSED EXPERT SYSTEM HAS THE POTENTIAL TO ASSIST RADIOLOGISTS IN THE INTERPRETATION OF DIAGNOSTIC IMAGES AND CLINICAL DATA USING ARTIFICIAL INTELLIGENCE. THE SYSTEM WAS FORMED BY ENCODING IN THE COMPUTER SOFTWARE THE KNOWLEDGE OF HUMAN EXPERTS. T ...