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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. MethLock vs. heparin as dialysis catheter lock

    SBC: ASH ACCESS TECHNOLOGY, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Currently about 25% of patients on hemodialysis therapy for End Stage Renal Disease (ESRD) receives dialysis through tunneled central venous catheters for dialysis (CVCD). The standard anticoagulant lock for these catheters is heparin, which has no antibacterial properties. The greatest risk for ESRD patients using CVCDs access is catheter related bloodstream i ...

    SBIR Phase I 2005 Department of Health and Human Services
  2. Cord Blood Stem Cell Expansion Ex Vivo With Endothelial Progenitor Cells

    SBC: Endgenitor Technologies, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Bone marrow transplantation is an effective means to treat patients with inherited or acquired defects in blood formation. However, only 1/3 of the potential recipients can find suitable donor grafts. Human umbilical cord blood contains sufficient hematopoietic stem (HSC) and progenitor cells to engraft related recipients (even adults). A limitation to more wid ...

    SBIR Phase I 2005 Department of Health and Human Services
  3. An Anti-Smoking Video Game for Pre-adolescent Girls

    SBC: GABRIEL INTERACTIVE, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The purpose of this study is to develop an interactive PC computer game (with a working title of "Escape From Nicotinia") that will encourage young girls, ages 8-12, to make sound and informed decisions concerning smoking, and thereby prevent initiation of smoking and subsequent nicotine addiction. The specific aims for Phase I are to: create a preliminary desi ...

    SBIR Phase I 2005 Department of Health and Human Services
  4. Extracting Semantic Knowledge from Clinical Data Sources

    SBC: LOGICAL SEMANTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Electronic medical record systems (EMR) contain a wealth of clinical data that is invaluable for biomedical research, but because there are no satisfactory methods to build coherent specialized knowledge bases, which represent the information in free text medical records, data mining and clinical discovery are held back. Medical Reporting Solutions, Inc. has ...

    SBIR Phase I 2005 Department of Health and Human Services
  5. Advanced Medical Speech Recognition

    SBC: LOGICAL SEMANTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Electronic medical record systems (EMR) are held back because data entry is slow, expensive, and codified in a format unsuitable for relational database repositories. Medical Reporting Solutions has developed advanced technology, which can overcome these problems through new methods to encode knowledge in medical reports, and a domain specific speech recogni ...

    SBIR Phase I 2005 Department of Health and Human Services
  6. ACGME duty hour compliance--Medical resident scheduling

    SBC: MEDICAL DECISION MODELING, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this study is to create easy-to-use interactive computer simulation software that analyzes residency scheduling alternatives that comply with the requirements of the Accreditation Council for Graduate Medical Education. The new guidelines constrain the number of days and hours that residents are available to work in teaching hospitals. Therefore ...

    SBIR Phase I 2005 Department of Health and Human Services
  7. A new cancer protein solubility tool: entropic bristle

    SBC: Molecular Kinetics Inc            Topic: N/A

    DESCRIPTION (provided by applicant): Expression and purification of cancer-associated proteins are prerequisite steps necessary to study their functions, structures, and interactions. However, these steps are often challenging or even infeasible due to poor protein solubility. Currently, various strategies exist for improving recombinant protein solubility, but many proteins are still poorly so ...

    SBIR Phase I 2005 Department of Health and Human Services
  8. Development of an Acoustic Biological Shaker

    SBC: RESODYN CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project will demonstrate the feasibility of using ResonantAcoustics (low-frequency acoustic mixing) as the basis for developing a highly efficient laboratory scale ResonantAcoustic Biological Shaker (RBS). Conventional biological orbital shakers have substantial drawbacks that include low oxygen transfer capabilit ...

    SBIR Phase I 2005 Department of Health and Human Services
  9. Diffraction Enhanced Imaging Laboratory Research Machine

    SBC: Nesch, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Diffraction enhanced imaging (DEI) is a novel approach to X-ray imaging that has the potential to revolutionize X-ray medical imaging, because of its greater contrast at lower delivered X-ray doses than conventional radiography. DEI relies on measuring tiny angular deflections of a collimated X-ray beam as it passes through the object (patient) in acquiring the ...

    STTR Phase I 2005 Department of Health and Human Services
  10. In vivo Thermoacoustic Imaging of HER2 Status

    SBC: OPTOSONICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): In this Fast Track application, we propose developing the novel imaging technology and molecular probe that will enable the non-invasive detection and quantification of HER2 overexpression in breast cancers. The approach we are promoting is to label Herceptin, a therapeutic mono-clonal antibody, with an infraredabsorbing dye, and then to detect the presence ...

    SBIR Phase I 2005 Department of Health and Human Services

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