Award Data

DESCRIPTION (provided by applicant): Use of prescription opioids for chronic non-cancer pain (CNCP) has escalated rapidly in the past two decades. Prescription opioid abuse is the fastest growing form of drug abuse, and prescription opioids are now the top cause of accidental drug overdose. The FDA plans to issue a Risk Evaluation and Mitigation Strategy to manage risks associated with chronic opi ...

DESCRIPTION (provided by applicant): Advanced Medical Electronics Corp, in collaboration with the Johns Hopkins University School of Medicine, proposes to develop a hardware/software platform suitable for administering a variety of tests and survey instruments to underserved populations in settings that can range from living rooms to libraries, community centers to nursing homes, and from inner ci ...

DESCRIPTION (provided by applicant): This STTR application is to develop and test for eventual clinical use a new strategy for tumor specific anticancer drug delivery. The technology, Clostridia-directed enzyme prodrug therapy, or CDEPT, exploits the fact that certain non-pathogenic bacteria of the Clostridia genus, which only grow in the absence of oxygen (hypoxia), colonize the hypoxic and necr ...

DESCRIPTION (provided by applicant): Pain is the primary reason that people seek medical care. Unfortunately, under-treatment of pain is well- documented in cancer (Cohen et al, 2003; Deandrea et al., 2008) and other medical conditions (Boulanger et al., 2007; Hadjistavropoulos et al., 2006). While medication continues to be the first line of defense against pain, empirical support for the effecti ...

DESCRIPTION (provided by applicant): Over 90% of cancer patients that enroll in Phase I or II clinical trials experience no benefit from the experimental therapies, yet are exposed to drug toxicity and other challenges related to treatment. For over 50 years, physicians have used patient-specific information about drug resistance and sensitivity to select antibiotics for patients with infections, ...

DESCRIPTION (provided by applicant): It is uniformly recognized that sedentariness - the sitting disease - is bad for the health of the nation. The solution to reversing sedentariness involves devising and disseminating real-world solutions to promote day-long physical activity and help people who want to, to lose weight and improve their blood glucose, lipids and blood pressure. The Gruve is ...

DESCRIPTION (provided by applicant) Every year millions of hearing tests are conducted in the U.S. for a variety of reasons, including diagnosis of ear disease, evaluation of communicative function, monitoring effects of noise and ototoxic medications. prospective research studies, and fitting of hearing aids. Although there is a "standard" hearing test method, th ...

DESCRIPTION (provided by applicant): Dialectical Behavior Therapy (DBT) is a multimodal, psychosocial treatment with demonstrated efficacy in treating borderline personality disorder (BPD). In Phase I, we developed and evaluated a pilot videotape of Marsha M. Linehan, Ph.D., teaching a DBT emotion regulation skill. Results demonstrated the videotape's efficacy at impa ...

DESCRIPTION: The number of persons in the United States with dementing disorders, now between 4-5 million, will quadruple in 50 years. One consequence of the progressive nature of dementia is that family caregivers must assume the role of primary decision makers. This Phase I proposal will develop an Internet-based prototype and companion CD-ROM Dementia Decision-making Guide based ...

DESCRIPTION: (taken from the abstract) The goal of this Phase II Small Business Technology Transfer Grant Application is to build and evaluate a commercial quality orthodontic Headgear Monitoring System that provides a quantitative measure of a patient's headgear use (both time and force). The Headgear Monitoring System consists of a headgear monitor, a communic ...