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Project Summary The goal of this Fast Track STTR project is to determine proof-of-principle and efficacy of a novel blood brain barrier (BBB) penetrating therapeutic nanoparticle for the potential treatment of otherwise intractable brain tumors like glioblastoma multiforme (GBM). This project seeks to demonstrate that novel, targetable nanoparticles can delivery therapeutic substances to human bra ...

The goal of this project is to develop a treatment booth with technology that allows opioid treatment programs to remotely dispense, either methadone or buprenorphine, under medical observation through telemedicine to a patient in a treatment booth. We believe that robotic automation is the ideal application to perform the same mechanical functions of the nurse at the dosing window. Specifically, ...

Abstract Pharmacogenomics, the study of how an individual's genetic makeup affects their response to drugs, has undergone rapid advancements. This has occurred alongside a decrease in the cost of genotyping technology, making implementation of pharmacogenomics into clinical practice increasingly feasible. Personalized medicine leveraging pharmacogenomics is gaining momentum to optimize drug choice ...

Project Summary / Abstract DermaXon's project goal is to develop efficacious, substrate-based, selective inhibitors of CYP26s, the enzymes responsible for the metabolism of all-trans retinoic acid (atRA) in the epidermis, as an oral treatment for severe recalcitrant acne. This approach will provide an improved acne therapeutic without the adverse effects associated with currently marketed retinoid ...

Select microbes contain an enzyme that promotes the hydrolysis of urea (ureolysis). This triggers an increase in pH and carbonate concentrations that, in turn, can cause dissolved minerals to precipitate and form solids similar to limestone. Recent resear

The overall goal of this multiphase STTR program is to develop a pulsed source of high purity entangled photons suitable for use at the Air Force’s Starfire free space optical range to support advances in free space quantum networking hardware and protoco

The overall goal of this multiphase STTR program is to develop fully packaged waveguide-based biphoton sources with high brightness and ultra-high, well characterized heralding efficiency. The specific goal of this phase I STTR is to establish the feasibi

  Mission success in contingency operations depends on communication and Beartooth Radio provides a solution when traditional comms are degraded; saving lives by reducing much-needed time battle-tracking friendlies and engaging the enemy when and where it

The Hi-Q Military Antenna product is compact, high power, mobile high frequency (HF) radio antennas for the US military, allied nations and commercial customers world-wide. This product enables customers to communicate rapidly, using HF radios, over long

The Hi-Q Military Antenna product is compact, high power, mobile high frequency (HF) radio antennas for the US military, allied nations and commercial customers world-wide. This product enables customers to communicate rapidly, using HF radios, over-the-h