Award Data

DESCRIPTION (provided by applicant): The goal of the proposed research is to develop two prototype drug analyzers interfaced with automated analysis readers for low risk monitoring of illicit drug levels by Surface Enhanced Raman Immuno Assay (SERIA). The first prototype will be placed in a clinical setting. This study will include urine and saliva samples collected from clients of a juvenile ass ...

"Gelled bipropellants provide advantages over liquid or solid gels. The conversion of advanced liquid oxidizers and fuels to gel greatly increases the safety of storage and use of bipropulsion materials in missile systems. Operational advantages of thegelled propellents over solid fuels include the ability to modulate fuel burn rate. The deliverable for this Phase II proposal is an advanced mix ...

The goal is to develop an automated and rapid system for human testing using dimorphic Alu repeats as genetic markers. Dimorphic Alu repeats are novel bi-allelic genetic markers that are identical by descent and stable. During the Phase I, we have demonstrated that the Alu markers can be caused for human identification. We have demonstrated that the Alu markers can be multiplexed and detected by h ...

Acetaminophen and NSAIDs have been used routinely for treatment of pain and/or fever. This dual action is sometimes contraindicated. In many instances, pain needs to be controlled without masking symptomatic fever (e.g., during the postoperative period). These drugs can cause hepatotoxicity, particularly after ingestion of large doses or from chronic use (especially when liver function has been co ...

We will develop a commercially available vaginal suppository containing a hydrogenperoxide-producing strain of Lactobacillus for use in colonization of the vagina. In this project, a strainof Lactobacillus will be identified based on adherence to vaginal epithelial cells, hydrogen peroxideproduction, and growth characteristics. Methods for strain preservation and maintenance of viability,biochemic ...

This proposal addresses the need to develop products which will help participants in health care assquality and level of care furnished to patients. We will develop a prototype ¿Protocol Engine¿, withdesigned for personal computers and computer networks, to allow protocols to be defined and customizspecific needs of the organization; to link and/or access data from other medical software package ...

Dengue virus causes dengue fever, a debilitating illness marked by high fever, headache, muscleand joint pain, and rash. The more severe forms of the illness, dengue hemorrhagic fever and dengueshock syndrome, are life threatening and are a principal cause of hospitalization among children inSoutheast Asia. Globally, the four serotypes of dengue are responsible for up to 100 million infectionsannu ...

The neurotoxins of Clostridium botulinum are the most lethal proteins known. The bacterium is ubiquitous, and thus rapid, reliable, sensitive, and cost-effective assays are needed to detect the toxin. Current immunoassays provide a rapid means to detect the neurotoxin. Their sensitivity, however, is limited by the affinity of the detecting antibody. The objective of this research, therefore, i ...

We proposed to integrate second generation infrared thermography, real time image analysis and patient information stored in a medical database into the risk assessment for breast cancer patients, detection and diagnosis of breast cancer and prognostic determination for breast cancer patients. Previous attempts to use first generation thermographic instruments showed that the results were applica ...

The information produced by the Human Genome Project and related research is expected torevolutionize biology and medicine in general and recombinant DNA technology in particular. At present,however, obtaining patent protection for inventions involving recombinant DNA technology is anacknowledged bottleneck in the development of the U.S. biotechnology industry. While much attentionhas been focused ...