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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A Phase 2 clinical trial of topical uracil for the prevention of capecitabine induced hand-foot syndrome

    SBC: NANOMETICS LLC            Topic: 102

    Problem to be SolvedCapecitabine is a widely prescribed and orally available prodrug of the chemotherapeutic agentfluorouracilFUThe principle dose schedule limiting toxicity associated with its use is Hand Foot syndromeHFSand occurs inof patients receiving capecitabineHFS manifests in the hands and feet of patientsand rapidly progresses to painful peelingblisteringand bleeding that commonly requir ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Automation of a Liver Genotoxicity Assay

    SBC: Litron Laboratories Ltd            Topic: NIEHS

    DESCRIPTIONprovided by applicantAssessment of chemicalspotential to cause chromosomal damage is an established and important part of preclinical genotoxicity safety testing for many consumer productsindustrial chemicalsand all pharmaceutical agentsCurrently the mammalian erythrocyte micronucleus test is the most commonly employed assay for in vivo assessment of chromosomal damagebut this assay rep ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Large Scale Synthesis of the Next Generation Synthetic Saponin Adjuvant TiterQuil

    SBC: ADJUVANCE TECHNOLOGIES INC.            Topic: NIAID

    PROJECT SUMMARY Vaccines against infectious diseases continue to improve public health across the worldWith increased knowledge of etiologic pathogens and necessary immune responses have come increasingly safe and defined or targeted vaccinesThe success of defined vaccines requires use of an immunological adjuvant to permit more effective immunizationFew adjuvants have sufficient potency and accep ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Optimization of Supercritical Carbon Dioxide Based Virus Inactivation, Characterized by Protein Damage and Maintenance of Epitope Integrity in Vaccine Sterilization

    SBC: NOVASTERILIS, INC.            Topic: R

    Project Summary The process combining supercritical COand co sterilants produces strong synergistic microbicidal effects in relatively mild conditionsThe mechanism of microbe inactivation is not well characterizedbut the disruption of lipid membranes and mild oxidative damage appear to be involvedThe processwhich is also highly efficient against virusesis considered to be very mild compared to oth ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Ecosystem for credentialing and supporting a bilingual provider workforce

    SBC: Transcendent International, LLC            Topic: 102

    Limited English proficientLEPpatients who struggle to understand their care providers report difficulty navigating both administrative and clinical proceduresleading to poorer outcomes than their English proficient counterpartsDespite numerous federal and state mandates requiring adequate language assistancehealthcare organizations have had limited success in implementing appropriate servicesFacin ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  6. VEIL (Vulnerability-reducing Engineered Infrared-obscurant Load)

    SBC: OCEANIT LABORATORIES INC            Topic: A13044

    Oceanit proposes to scale-up processes for low cost obscurant materials. These processes include the development , fabrication, and testing of materials and coatings.

    SBIR Phase II 2017 Department of DefenseArmy
  7. Science Take-Out Kits for Environmental Health Education

    SBC: Science Take-Out, LLC            Topic: NIEHS

    ABSTRACT Nearlypercent of death and diseaseworldwideis linked to environmental factorsWHOthereforeit is critical that the general public has a basic understanding of how the environment affects their health and how they might protect themselves against environmental exposuresUnfortunatelyenvironmental health is typically covered minimallyif at allin secondary school classroomsMartinaand there are ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Mouse Stem Cell Research Using the Dracula Pipette

    SBC: GENESEARCH, INC.            Topic: 100

    Advanced approaches for genetic or epigenetic modification of embryonic stemEScellsincluding TALENZFNor CRISPR catalyzed genetic modifications or modulation of gene expression via small RNAssynthetic mRNAsor recombinant transcription factorshave revolutionized our ability to modify the cells from which novel mouse lines are producedIn contrastprocedures for utilizing these cells within the context ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Next generation CRISPR/Cas9-RNAi mouse models for accelerated drug discovery research

    SBC: MIRIMUS INC            Topic: 100

    Abstract SignificanceNew approaches for rapid identification and early preclinical validation of novel therapeutic targets are crucial to make importantgo no godecisions and curb the cost of developing new cancer treatmentsGenetically engineered mouse modelsGEMMsare a powerful platform to study disease initiation and maintenancethe tumor microenvironment and the responsiveness of cancers to known ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  10. An Evidence-based Approach for Bullying Prevention

    SBC: National Health Promotion Associates, Inc.            Topic: NICHD

    ABSTRACT An Evidence-Based Serious Game Approach for Bullying Prevention Administrative SupplementBullying, in its most familiar form, is a serious public health concern. This is especially true during the middle-school years, a transition period when bullying increases. Cyberbullying, an electronic evolution of face-to-face bullying, is willful and repeated harm inflicted through computers, cell ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
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