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This proposal addresses the need to develop products which will help participants in health care assquality and level of care furnished to patients. We will develop a prototype ¿Protocol Engine¿, withdesigned for personal computers and computer networks, to allow protocols to be defined and customizspecific needs of the organization; to link and/or access data from other medical software package ...

The wavelet transform has generated excitement among researchers from a wide range of disciplines. Wavelets have an extremely rich mathematical foundation and have been proven valuable for a variety of applications. New ideas are being pursued at a breathtaking pace leading to innovative algorithms. The challenge before us now is to identify and harness these ideas and develop a coherent set of ...

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Naso-gastric (NG) feeding tubes are used to deliver nutrition to patients who cannot eat for themsehomes, hospitals, and home care settings. Improper placement into the lungs or trachea of NG tubes bin complications, including pneumonia and death. Currently, the only certain method of proper NG tubradiographic - an X-ray film is taken of the abdomen to verify the location of the tip of the NG tubd ...

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We will develop a high reliability, high-energy, rechargeable power cell that will be small enoughto be incorporated in an in-the-ear (ITE) device and contain adequate power to operate a hearing aidreliably for 1 day, with backup power to operate for an additional 2 days (assuming normal hearing aidusage). The rechargeable cell will last for the entire 3-5 year lifetime of the hearing aid. Include ...

Our research will develop a scaleable GMP manufacturing process for the production of adeno-associa(AAV) vectors for the treatment of cystic fibrosis. AAV-CFTR vector constructs will be introduced inlines and evaluated for their ability to produce vector particles following addition of requisite panumber of packaging constructs will be assayed in the vector-containing cell lines for their abilityp ...

The information produced by the Human Genome Project and related research is expected torevolutionize biology and medicine in general and recombinant DNA technology in particular. At present,however, obtaining patent protection for inventions involving recombinant DNA technology is anacknowledged bottleneck in the development of the U.S. biotechnology industry. While much attentionhas been focused ...

THE LONG-TERM OBJECTIVE IS TO MAKE AVAILABLE TO UROLOGISTS AND SPECIALLY TRAINED TEAMS OF TECHNICIANS THROUGHOUT THE WORLD A SIMPLE, RELIABLE, LOW-COST MACROSURGICAL VASOVASOSTOMY SYSTEM. OFFERED IN A RESTOCKABLE KIT FORMAT, THE ARMAMENTARIUM WOULD INCLUDE A VAS LUMEN SIZING GAUGE, A SELECTION OF FLOW-THROUGH ABSORBABLE VAS STENTS, MICROSUTUTERS, AN IMPROVED VAS STABILIZING CLAMP, AND TWO SPECIAL ...