Award Data

DESCRIPTION (provided by applicant): Digoxin is the first line pharmacologic therapy for CHF and AF. Digoxin increases cardiac contractility and blocks conduction through the AV node slowing the ventricular response to AF and thus slowing the rate of the beating ventricles permitting more time for the heart to fill. The recent Dig trial supports the use of digoxin in the treatment of CHF and the r ...

DESCRIPTION (provided by applicant): Stroke is the third leading cause of death in the United States and is the number one cause of adult disability. It is estimated that this clinical condition results in a cost of $30-40 billion in the U.S alone. While a large number of therapeutic agents have been investigated for the treatment of ischemic stroke, only one agent is currently approved for marke ...

Efficient and portable POWER, to drive the Military's Future Combat technology and equipment is the key to a successful Future Force. Belle Aerospace Corporation is proposing a very compact, lightweight portable power generation system for use in small Military Tactical Generators (MTG) in the 250 to 2000 Watt power range. Using a proven generator and power electronics technology from Hamilton Sun ...

DESCRIPTION (provided by applicant): The long-term objectives of this project are to: (a) Formulate an oral iron/ascorbic acid supplement specific to the needs of renal transplant recipients (RTxRs), (b) evaluate the efficacy of oral iron/ascorbic acid supplementation to meet the iron needs of this patient population as part of their routine post-transplant (post-Tx) care, and (c) establish a cons ...

DESCRIPTION (provided by applicant): The long-term objectives of this project are to develop a novel non-invasive test of insulin resistance. The proposed test is based on the well-established principle of inverse relationship between glucose oxidation (Gox) and lipid oxidation (Lox) during cellular respiration. Because the ratio of whole-body Gox/Lox can be measured precisely after administratio ...

DESCRIPTION (provided by applicant): Iron deficiency anemia (IDA) is a major problem among adults and elderly. In men and postmenopausal women, IDA is currently thought to result from gastrointestinal (GI) blood loss. Despite thorough GI tract evaluation, a significant number of patients are found to be negative for fecal occult blood (FOB) and >30% do not have lesions consistent with chronic bloo ...

DESCRIPTION (provided by applicant): The PROsIT Project seeks to promote the use of patient-reported outcomes (PROs) for HIV-infected patients in clinical settings by developing and commercializing a comprehensive, practical and integrated system for PROs management with cross-discipline efforts. In Phase I, we successfully implemented and pilot-tested an IRT-based adaptive PROs assessment engin ...

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DESCRIPTION (provided by applicant): Chicago PT is developing rehabilitation robotics to help clinicians provide more intensive functional retraining of overground walking, post-stroke. Chicago PT's concept is to build devices that work with the clinician rather than replacing the clinician, in order to retain the clinician's skilled manual connection with the patient in all its important aspects: ...

Increased production of protein from senescent cells. Monoclonal antibodies (mAbs) are emerging as robust therapeutic options in the fight against cancer and autoimmune diseases. The estimated market in 2004 for therapeutic mAbs is more than $7 billion from 16 FDA approved biopharmaceutical products. Kilogram quantities of mAbs are produced on in large-scale bioreactors from traditional hybridoma ...