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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Discovery of new small molecule TLR4 agonists for the treatment of allergic rhinitis

    SBC: INIMMUNE CORP            Topic: NIAID

    The long term goal of this proposal is the development of an intranasal stand alone TLRagonist to treat allergic rhinitisUnlike antigen specific therapythis allergen independent approach will be broadly applicable to a vast array of allergens patients are exposed toSuch treatment would provide relief within hours of administrationproviding short term symptom controland has the potential to deliver ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Drone-Based Gas Mapping LiDAR for Leak Mitigation

    SBC: Bridger Photonics, Inc.            Topic: 17NCER2C

    Bridger Photonics, Inc. proposes developing a drone-based Gas Mapping LiDAR™ sensor to mitigate the loss of valuable product across the Oil & Gas supply chain.The sensor will uncover leaks and physical changes to infrastructure and pipeline right-of-ways using high-resolution 3D topographical imagery with methane gas concentration overlays.The technology will enable reliable detection, precise l ...

    SBIR Phase I 2018 Environmental Protection Agency
  3. Acoustic Scaffold Bioreactor

    SBC: RESODYN CORPORATION            Topic: NHLBI

    This Small Business Innovation Research Phase II project will develop a commercially viable device that uses micro scale acoustic streaming low frequency sound energy to deliver mixing to the interior of three dimensional D scaffolds used for stem cell cultivation applications The enabling advantage of low frequency sound energy is the ability to generate micro scale mixing in and around sca ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Low Cost Handheld Tactile Imaging Device for Breast Cancer Screening

    SBC: VAJRA INSTRUMENTS, INC.            Topic: 102

    Palpation has been routinely used by physicians to diagnose diseases for centuries In Clinical Breast Examination CBE medical personnel screen for suspect lesions that are to fold stiffer than surrounding tissue by palpation using two or three fingers followed by precession about a fixed in contact area Typical pressure to avoid discomfort and also feel deeper palpable objects r ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Prosthetic System for Large Scale Recording and Manipulation of Neural Circuit Activity in Non Human Primates

    SBC: Gray Matter Research            Topic: 105

    The fundamental objective of the BRAIN Initiative is to understand how dynamic activity in distributed neural circuits mediates human cognitive behavior The non human primate NHP is a key animal model in this effort due to the close similarities of its brain to that of humans and its ability to perform complex cognitive tasks However developing and testing novel hypotheses for how neural cir ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. MUC assay for the early diagnosis and management of benign and malignant pancreatic diseases

    SBC: Sanguine Diagnostics And Therapeutics, Inc.            Topic: 300

    Abstract The goal of this Fast track application is to develop a non invasive diagnostic test based on MUC and MUC mucins that can serve as an adjunct to cytological analysis of fine needle aspirates FNAs for accurate prediction of malignancy in patients with cystic pancreatic lesions Due to asymptomatic nature and lack of methods for early detection andgt of pancreatic cancer PC p ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Integrating CNV analysis into a NextGen sequencing clinical analytics platform

    SBC: Golden Helix, Inc.            Topic: 400

    Copy Number Variations CNVs are a common cause of disease in humans As of today CNVs are most often detected using microarrays However microarrays are expensive and are not able to effectively detect CNVs below K bp range This project is designed to detect both point mutations and CNVs in one clinical test without having to utilize microarrays It is our goal to develop an easy to use solu ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A robust assay for detecting agonist bias in living cells

    SBC: Montana Molecular LLC            Topic: 300

    PROJECT SUMMARY The goal this Phase SBIR project is to develop an agonist bias assay for screening drugs that target seven transmembrane G protein coupled receptors GPCRs Phase will establish the feasibility of a robust assay platform to detect when particular GPCR agonists activate both arrestin and G protein pathways This assay will detect responses in living cells on automated fluores ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Development of Selective Inhibitors of NaV as Therapeutics for Pain

    SBC: Siteone Therapeutics, Inc.            Topic: 108

    PROJECT SUMMARY This program aims to develop a novel non opioid therapeutic for the treatment of pain that targets a subtype of the human voltage gated Na ion channel NaV Preliminary data indicate that SiteOneandapos s lead drug candidates may be more effective than opioids for treating certain types of pain and lack the side effects associated with opioid analgesics which include nausea ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Profiling Circulating miRNA Without PCR for Early Detection of Pancreatic Cancer

    SBC: VAJRA INSTRUMENTS, INC.            Topic: 102

    DESCRIPTION provided by applicant Pancreatic cancer PaC has a poor prognosis in most cases due to the lack of early detection owing to its nonspecific asymptomatic nature An effective inexpensive screening tool is needed for early diagnosis within years of tumor initiation It is well accepted that genomic instability is a hallmark of cancer Recent research indicates that less than ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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