Award Data

C56-10d-273616To meet the need for more sustainable manufacturing supply chains with reduced greenhouse gas emissions and to remove reliance on foreign supply chains, policymakers and researchers have begun exploring the possibilities of biomanufacturing commodity chemicals and materials. Acrylates are a primary monomeric component in paints, coatings, plastics, and super-absorbent polymer applica ...

High-quality, defect free, and consistent thickness Proton Exchange Membrane (PEM) films are required to ensure maximum efficiency and longevity over the life of hydrogen fuel cells or electrolyzers utilizing this technology. The current technologies of PEM film Quality Assurance (QA) and defect detection rely on human inspection, which can be subjective and labor intensive, or measurement technol ...

PROJECT SUMMARY Alcoholic liver disease (ALD) is one of the major causes of morbidity and mortality in the world. Significant challenges remain for developing preventive or curative approaches targeting ALD. No effective treatments for ALD currently exist but for reducing alcohol consumption or liver transplantation. The current paucity of clinically relevant experimental models impedes any effort ...

The goal of this project is to develop a treatment booth with technology that allows opioid treatment programs to remotely dispense, either methadone or buprenorphine, under medical observation through telemedicine to a patient in a treatment booth. We believe that robotic automation is the ideal application to perform the same mechanical functions of the nurse at the dosing window. Specifically, ...

Abstract Pharmacogenomics, the study of how an individual's genetic makeup affects their response to drugs, has undergone rapid advancements. This has occurred alongside a decrease in the cost of genotyping technology, making implementation of pharmacogenomics into clinical practice increasingly feasible. Personalized medicine leveraging pharmacogenomics is gaining momentum to optimize drug choice ...

PROJECT SUMMARY While there are now successful treatment regimens and prevention strategies for people living with HIV/AIDS, the HIV pandemic remains a public health crisis in the United States and worldwide, with nearly 40,000 new infections each year in the US alone. To prevent the spread of HIV in vulnerable populations, the US Preventive Services Task Force has recommended HIV pre-exposure pro ...

Project Summary / Abstract DermaXon's project goal is to develop efficacious, substrate-based, selective inhibitors of CYP26s, the enzymes responsible for the metabolism of all-trans retinoic acid (atRA) in the epidermis, as an oral treatment for severe recalcitrant acne. This approach will provide an improved acne therapeutic without the adverse effects associated with currently marketed retinoid ...

Cloud cover is an important but poorly characterized component of current climate models. In particular, there is a need to detect and quantify cloud cover in a physically meaningful manner. This need has led to the development of infrared cloud imagers. This system uses long-wave infrared cameras to observe the thermal emission from the clouds and produces a measurement of spatially distributed c ...

Squeezed light sources are a critical component of continuous variable quantum networking and quantum computing systems. Periodically poled nonlinear optical waveguides are a promising technology for squeezed light sources due to high conversion efficiency, long interaction length, robust fiber coupling, and integration potential. While these waveguides are available commercially, they are not opt ...

Quantum optical networks will require all optical signal processing that is enabled by lithium niobate-based components. While many of these components are commercially available, they are not optimized for the ultra-low optical losses required for quantum applications. This program will develop refined processing techniques to fabricate ultra-low loss lithium niobate- based components, initially ...