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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Novel Catalyst Systems

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Transition metal catalysts are widely used in the pharmaceutical industry for the production of active ingredients, precursors and new drug candidates. These products must be very pure, often requiring labor and energyintensive separation processes, to achieve the required purity levels. Of special concern in the present context is to avoid contaminating the pr ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  2. Customized Nanofiltration Membranes for Enhancing Pharmaceutical Manufacturing

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): The overall focus of this application is to develop nanofiltration membranes to recover the spent solvents generated from drug manufacturing processes allowing the solvents to be reused resulting in elimination of waste. This is also responsive to NIH RFP PA-09-100 entitled Energy Efficiency and Renewable Energy System Technology Research and Development . By ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  3. Novel Materials and Methods for Separations of Glycopeptides and Glycans

    SBC: ADVANCED MATERIALS TECHNOLOGY, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Analysis of glycoprotein polypeptide sites of carbohydrate attachment and the structures of the glycans present on these proteins requires the combination of high resolution chromatographic separations and sophisticatedmass spectrometry. Hydrophilic interaction liquid chromatography (HILIC) has great use in separations of glycopeptides and released glycans, exh ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  4. Smaller Particle Fused-Core Silicas for Higher Performance Separations

    SBC: ADVANCED MATERIALS TECHNOLOGY, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Life sciences research and other critical bioanalytical applications would strongly benefit from faster and higher resolution liquid chromatographic (HPLC) separations for both small molecules and larger molecules suchas proteins, peptides, glycopeptides, and glycans. Many HPLC separations of biomedical interest, such as proteomic or glycomic profiling, require ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  5. Fast and Accurate Tools for Measuring Fluorescence in Living Cells

    SBC: MONTANA MOLECULAR LLC            Topic: NIMH

    DESCRIPTION (provided by applicant): Project Summary/Abstract Drug discovery depends crucially upon reliable assays for biological activity. Live cell assays provide a rich environment for measuring biological activity. Coupled with genetically encodedfluorescent biosensors, live cell assays have the potential to provide read-outs with unprecedented specificity for particular signaling pathway ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  6. Novel Nanofiltration Membranes for Isolation of Pharmaceutical Compounds

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: NCRR

    DESCRIPTION (provided by applicant): Novel Nanofiltration Membranes for Isolation of Pharmaceutical Compounds Project Summary: In the chemical manufacturing of pharmaceutical compounds, organic syntheses are often carried out in organic solvents and involve intermediates and final products with high added value. These pharmaceutical active compounds having molecular weights in the range of 300-200 ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  7. Low Light Level Camera For Raman Spectroscopy

    SBC: B & W TEK INC            Topic: NCRR

    DESCRIPTION (provided by applicant): Raman spectroscopy is a potentially important clinical tool for real-time diagnosis of diseases and in situ evaluation of living tissues. However, the application of Raman spectroscopy for tissue evaluation has been limited by the strong tissue fluorescence that often overwhelms the extremely weak Raman signal. The goal of this proposal is to develop an infrare ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  8. Enhanced Fluoropolymer Membrane Reactors for Production of Pharmaceutical Interme

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: NCRR

    DESCRIPTION (provided by applicant): The commercial syntheses of many pharmaceutical active ingredients and intermediates require acid catalysts and the removal of water to drive reactions to completion. Typical reactions include esterifications of carboxylic acids with alcohols, Friedel-Crafts acylations and alkylations, Schiff base, acetal and ketal formation and nitrations of aromatic compounds ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  9. Response-Selective C5a Agonist for the Treatment of Asthma

    SBC: Prommune, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): An unmet need in the treatment of allergic asthma is an effective therapeutic strategy that focuses on an underlying cause of the disease rather than merely treating or managing its symptoms. At least one well- accepted underlying contributor to the pathophysiologic expression of asthma is an over-expressed and dysregulated T helper type 2 (Th2)-mediated immun ...

    STTR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  10. Nanoparticles and Nanocapsules for Glioma Targeting

    SBC: LNKCHEMSOLUTIONS            Topic: NCI

    DESCRIPTION (provided by applicant): Malignant gliomas represent a heterogeneous family of tumors that are poorly responsive to current treatments. A major obstacle to the effective management of these lesions involves the difficulty in delivering adequateconcentrations of therapeutics to the tumor cells. In addition, the inability to image the distribution of therapeutic agent hampers the plannin ...

    SBIR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
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