Award Data

DESCRIPTION (provided by applicant): Type I diabetes is a widespread disease in which insulin producing pancreatic islets are lost, leading to unstable glucose levels. If the islets can be replaced, as with transplantation, then diabetes can be reversed.Human islets have limited utility because of a severe shortage of donors and the need for constant immune suppression to prevent rejection. Pigs ...

This Small Business Innovation Research (SBIR) Phase II project will employ the large scale; highly reliable boron-doped ultrananocrystalline diamond (BD-UNCD®) electrodes developed during Phase I project to build and test Electrochemical Anodic Oxidation process (EAOP) cells and systems that can destroy Contaminants of Emerging Concern more economically and effectively than competing AOPs. BD-UN ...

DESCRIPTION (provided by applicant): This project relates directly to the PHS 2011-2, Omnibus Solicitation for SBIR/STTR Grant Application page NIDCR 110: Development of instrumentation for early caries detection and comparison studies on specificity andselectivity with respect to current clinical practice. The proposed test is intended to enable dentists to differentiate between cavitated and ...

DESCRIPTION: The goal of the proposed project is to develop a biocompatible ultrafine particle-based vector system for the intranasal delivery of clozapine for the pharmacological therapy of treatment- resistant schizophrenic disorders and their associatedsuicidal behavior. The rationale behind the use of intranasal clozapine is grounded on the observation of clozapine's extensive first- pass ...

DESCRIPTION (provided by applicant): Ninety percent of all pancreatic cancers are pancreatic ductal adenocarcinoma (PDAC). PDAC diagnosis is difficult, usually occurring in the late stages of disease. Patients with these advanced tumors typically respondpoorly to therapy. Post diagnosis, median survival is 6 months and the five-year survival rate is lt 4%. Five-year survival is lt 1% for those wi ...

Our goal through this project is to demonstrate the feasibility and enterprise-wide benefits of Synesis7"s proposed approach for getting to an advanced common integrative, intelligent Automated Logistics Environment (ALE) planning, development, technology, integration, and deployment framework ("ALE Framework") solution. Establishing technical, operational, cost and commercial feasibility will be ...

The U.S. Navy seeks an in-situ powder coating material and application method for spot repair. Resodyn Corporation proposes a unique restoration and repair polymer thermal spray coating (R & RPTS) system that provides the ease of repair, safety in handling, and effective coating protection to fulfill the U.S. Navy needs. The proposed system will be a zero VOC, non-toxic, non-chromated material wit ...

Navy electronic support (ES) functions require receivers making true wideband RF / microwave measurements on transient & frequency hopping signals over 1-40 GHz and beyond, including spectral mapping (SM) and direction finding (DF) with low latency. Wideband digitizers in RF/Microwave receivers are expensive, create ~50 Gs/s of data to be handled in real time by large computer systems, and have in ...

Navy electronic support (ES) functions require receivers making true wideband RF / microwave measurements on transient & frequency hopping signals over 1-40 GHz and beyond, including spectral mapping (SM) and direction finding (DF) with low latency. Wideband digitizers in RF/Microwave receivers are expensive, create ~50 Gs/s of data to be handled in real time by large computer systems, and have in ...

This Navy Phase II SBIR effort will develop a packaged, high-speed optical amplitude modulator for use with a high-power, pulsed, blue laser that is being developed for lidar-based detection, ranging, and tracking of underwater objects in an ocean environment. While it is well known that laser sources in the blue/green spectral region increase the achievable range in ocean and coastal environments ...