Award Data

PROJECT SUMMARY This program aims to develop a novel non opioid therapeutic for the treatment of pain that targets a subtype of the human voltage gated Na ion channel NaV Preliminary data indicate that SiteOneandapos s lead drug candidates may be more effective than opioids for treating certain types of pain and lack the side effects associated with opioid analgesics which include nausea ...

DESCRIPTION provided by applicant Pancreatic ductal adenocarcinoma PDAC is a deadly form of cancer and patient survival depends upon the stage of diagnosis While overall survival at diagnosis is only about months of patients with stage I disease survive years The best currently available diagnostic test which is routinely performed in patients at high risk for PDAC is endoscop ...

DESCRIPTION provided by applicant This Phase I STTR project seeks to demonstrate proof of principle that novel targetable nanoparticles can delivery therapeutic substances to human tumor cells and reduce tumor burden in metastatic cancer The concept for these nanoparticles is based on the polymerized liposome nanoparticle PLN that displays functional antibodies that target tumor cell surfac ...

DESCRIPTION provided by applicant This proposal investigates the use of a novel passive personal monitoring system to stem the tide in the epidemic of deaths due to unintentional opioid drug overdoses In the U S in opioid drug overdoses including prescription pain relievers and heroin caused deaths a number that has increased dramatically over the past two decades A person w ...

DESCRIPTION provided by applicant There is an urgent need for a platform technology that can monitor changes in metabolite and protein biomarkers below current detection limits because in many cases the disease has progressed to an advanced state by the time the abundance of the biomarker has become measurable Our molecular motor powered nanodevice linked immunosorbent assay MONA LISA is ...

DESCRIPTION provided by applicant The adoption of Electronic Health Record EHR systems is growing at a fast pace in the U S and this growth results in very large quantities of patient clinical data becoming available in electronic format with tremendous potentials but also equally growing concern for patient confidentiality breaches Secondary use of clinical data is essential to fulfill ...

DESCRIPTION provided by applicant The long term goal of this Phase I STTR project is to develop a commercially viable ultrasound contrast reagent UCR that will allow the noninvasive identification of newly forming abdominal adhesions after surgery Successful implementation would have significant impact because we would remove the impediment to clinical testing of anti adhesion therapies and ...

Project Summary The long term objective of this project is to develop a new class of broad spectrum antibiotics focused on Gram negative bacteria Inspired by a natural product this class targets an unexploited binding site of the bacterial ribosome With ever increasing reports of resistance to frontline therapies addressing Gram negatives there is a critical need for new therapies yet very ...

DESCRIPTION provided by applicant Intraocular pressure IOP is arguably the second most important criteria used to assess visual acuity when eye care professionals are diagnosing treating and managing patients The patented Intuor Applanation Tonometer IAT prism design is a novel and simple approach for improving the accuracy of IOP measurement in the eye The proposal describes an inexpen ...

DESCRIPTION provided by applicant This is a SBIR Phase I application to develop new iron chelating drugs for prevention and treatment of iron overload induced bone loss in patients with thalassemia major TM a rare disease in the US Virtually all TM patients are affected by osteopenia and osteoporosis and these skeletal complications herald and contribute to a general clinical deterioratio ...