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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Diagnostics to enable Malaria and Neglected Tropical Diseases

    SBC: HDT Bio Corp.            Topic: NIAID

    The role of HDT Bio is to translate discovery into products for infectious diseasesIn this proposal we focus on producing a diagnostic test to aid in the elimination of leprosyWe will develop LepReactan improved and cost effective diagnostic intradermal skin test to permit screening for Mycobacterium leprae infectionLeprosy is a severe neurological disease caused by infection with Mlepraeand devel ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. A Novel Adjuvant-based Probiotic Platform for Generating Tolerance Therapeutics

    SBC: VIRTICI LLC            Topic: NIAID

    Autoimmune and allergic diseases affect overof the world population and are continuing to riseOur goal is to develop a novel adjuvant based probiotic platform to rapidly create tolerance inducing therapeutics for the treatment of allergy and autoimmune diseaseFor thiswe will leverage the reovirus protein sigmapwhich is a powerful tolerance adjuvantFusion proteins consisting of pwith an antigen of ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Discovery of new small molecule TLR4 agonists for the treatment of allergic rhinitis

    SBC: INIMMUNE CORP            Topic: NIAID

    The long term goal of this proposal is the development of an intranasal stand alone TLRagonist to treat allergic rhinitisUnlike antigen specific therapythis allergen independent approach will be broadly applicable to a vast array of allergens patients are exposed toSuch treatment would provide relief within hours of administrationproviding short term symptom controland has the potential to deliver ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. AlphaBear2

    SBC: Spry Fox LLC            Topic: EDIES17R0006

    This project team will fully develop and test AlphaBear 2, a vocabulary learning game for grade 4 to 7 students. Vocabulary is a prerequisite for academic success, as it is linked to stronger performance across academic subjects and improved reading comprehension. It is more difficult for students to participate in educational activities without understanding the key vocabulary associated with tha ...

    SBIR Phase II 2017 Department of EducationInstitute of Education Sciences
  5. A Collaborative Interface for Teacher-Student Interaction in Virtual Environments

    SBC: STRANGE LOOP GAMES INC.            Topic: edIES17R0005

    In prior projects, including a 2015 ED/IES SBIR award, the team developed two immersive multiplayer virtual game environments. In Eco and Colony, middle school students collaboratively apply scientific practices within the virtual worlds to address challenges, such as the availability of resources and energy and maintaining clean water. With this Phase I funding, the team is developing a prototype ...

    SBIR Phase I 2017 Department of EducationInstitute of Education Sciences
  6. Correlating TCR diversity to immune reconstitution after cord blood transplant

    SBC: ADAPTIVE BIOTECHNOLOGIES CORPORATION            Topic: NHLBI

    DESCRIPTION provided by applicant Many patients requiring stem cell transplantation for hematological malignancies are unable to find a suitable HLA matched sibling or unrelated donor Transplants using stem cells from umbilical cord blood provide an alternative for these patients allowing transplantation to proceed with less stringent HLA matching requirements Unfortunately in addition to t ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Development of an Innovative Effective RNA based Vaccine for Chikungunya Virus

    SBC: PAI Life Sciences, Inc.            Topic: NIAID

    PROJECT SUMMARY ABSTRACT Chikungunya virus CHIKV is an emerging disease of global public health importance Originally identified in sporadic CHIKV outbreaks occurred in Africa and Asia for several decades Beginning with an outbreak on the island of La Reunion in the virus has continued to spread to new regions around the globe CHIKV is now endemic in the Caribbean is present in t ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Fixed site and wearable monitors for assessment of personal exposure to airborne chemicals

    SBC: XPLOSAFE, LLC            Topic: 113

    Project Summary Abstract People in all facets of life are exposed to volatile toxins that may cause them to unexplainably sicken The NIEHS Exposure Biology and Exposome Program has the ambitious and worthy goal to track a person s exposures from conception to death and correlate these with biological responses and health outcomes Achieving this goal will require numerous inexpensive sensors that ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. A Preclinical Trial of Therapeutic Angiogenesis Plus Angioplasty and Stenting for Renal Vascular Disease

    SBC: Leflore Technologies LLC            Topic: 400

    Abstract Chronic kidney disease CKD is a progressive disorder affecting almost of the general population and this disease has shown a relentless growth over the past decades Patients with CKD have higher rates of hospitalization greater mortality shorter life expectancy and their healthcare costs are up to times more expensive than non CKD patients Thus treatments to slow halt ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Development of Environmental Health Education Games

    SBC: MEADOWLARK SCIENCE AND EDUCATION, LLC            Topic: NIEHS

    PROJECT SUMMARY Improving STEM focused curriculum is a primary objective of the current U S administration and is crucial for ensuring that upcoming generations receive the training and skills necessary to compete in the existing global economy To that end there is an urgent need for additional effective teaching tools able to reach a generation that requires instant access to information and a ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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