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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Novel Circulating RNA-based Markers as Diagnostic Biomarkers of Infectious Diseases

    SBC: CFD Research Corporation            Topic: CBD18A001

    In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens,whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial andalphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable and ...

    STTR Phase I 2018 Department of DefenseOffice for Chemical and Biological Defense
  2. Infectious Disease Diagnostics and Differentiation of Viral vs. Bacterial Infections for Point ofCare Applications

    SBC: GENECAPTURE            Topic: CBD15C001

    GeneCapture, Inc. is proposing to develop a rapid in vitro diagnostic prototype using our patented molecular-based CAPTURE (ConfirmActive Pathogens Through Unamplified RNA Expression) assay. Based on the results and experience gained in our Phase I STTR contractHDTRA1-16C-0061: Infectious Disease Diagnostics and Differentiation of Viral vs. Bacterial Infections for Point of Care Applications, we p ...

    STTR Phase II 2018 Department of DefenseOffice for Chemical and Biological Defense
  3. AlphaBear2

    SBC: Spry Fox LLC            Topic: EDIES17R0006

    This project team will fully develop and test AlphaBear 2, a vocabulary learning game for grade 4 to 7 students. Vocabulary is a prerequisite for academic success, as it is linked to stronger performance across academic subjects and improved reading comprehension. It is more difficult for students to participate in educational activities without understanding the key vocabulary associated with tha ...

    SBIR Phase II 2017 Department of EducationInstitute of Education Sciences
  4. A Collaborative Interface for Teacher-Student Interaction in Virtual Environments

    SBC: STRANGE LOOP GAMES INC.            Topic: edIES17R0005

    In prior projects, including a 2015 ED/IES SBIR award, the team developed two immersive multiplayer virtual game environments. In Eco and Colony, middle school students collaboratively apply scientific practices within the virtual worlds to address challenges, such as the availability of resources and energy and maintaining clean water. With this Phase I funding, the team is developing a prototype ...

    SBIR Phase I 2017 Department of EducationInstitute of Education Sciences
  5. Producing Novel Biosynthetic Therapeutics from Extreme Microbiomes

    SBC: IXPRESSGENES, INC.            Topic: CBD152004

    This project is a unique metagenomic evaluation of under-studied extremophilic microbiome natural products (NPs), with the goal of discovering novel antibiotic biowarfare agent (BWA) countermeasures. A metagenomic biosynthetic gene cluster library from extremophilic sources was created, sequenced, analyzed, and exploited to produce several broad-spectrum antibiotic extracts during the Phase I effo ...

    SBIR Phase II 2017 Department of DefenseOffice for Chemical and Biological Defense
  6. Smartphone Application for Mask Sizing and Projecting Quantitative Fit

    SBC: CFD Research Corporation            Topic: CBD161005

    Typical procedures for respirator masks sizing and protective fit test are time-consuming and user intensive, requiring taking anthropometricmeasurements of the wearer, sampling the wearers breathing zone and the use of specialized tools and equipment. The proposed softwareapp aims to quickly, accurately and automatically perform respirator mask sizing and predict protective fit using only 2D imag ...

    SBIR Phase II 2017 Department of DefenseOffice for Chemical and Biological Defense
  7. Exploiting Natural Products-Based Therapeutics for Aflatoxin Mitigation

    SBC: CFD Research Corporation            Topic: CBD152003

    Aflatoxins B1 (AFB1) are fungal produced mycotoxins that are present in food supplies and are strongly associated with increased risk for thedevelopment of hepatocellular carcinoma. Currently, there are no known countermeasures to selectively mitigate AFB1 toxicity. To meet thischallenge, we successfully validated a Phase I proof-of-concept study to harness the microbiome extracts of scavenging ma ...

    SBIR Phase II 2017 Department of DefenseOffice for Chemical and Biological Defense
  8. AlphaBear

    SBC: Spry Fox LLC            Topic: 1

    In prior research and development, the team developed AlphaBear, a mobile gaming app where students are challenged to spell words which are then used to create humorous sentences. This project will develop and test a prototype for use specifically by English Learners. The prototype will formatively assess students' vocabulary, adjust gameplay to the skill levels of individual students, and provide ...

    SBIR Phase I 2016 Department of Education
  9. Exploiting Natural Products-Based Therapeutics for Aflatoxin Mitigation

    SBC: CFD Research Corporation            Topic: CBD152003

    Aflatoxins are a paradigm among fungal produced mycotoxins that are present in food supplies and are strongly associated with increased risk forthe development of hepatocellular carcinoma. Currently, there are no known countermeasures that can selectively mitigate aflatoxin toxicity andthe available options are only symptomatic treatments. To meet this challenge, we propose to harness the microbio ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  10. Producing Novel Biosynthetic Therapeutics from Extreme Microbiomes

    SBC: IXPRESSGENES, INC.            Topic: CBD152004

    Environmental DNA from three extreme samples will be isolated, cloned into a fosmid library (5760 clones) for sequencing. The sequencing datawill cover ~ 240 Megabases and will be assembled into contigs long enough (~ 40 Kilobases) to represent potential biosynthetic gene clusters(BGCs). This data will be compared to BGC databases looking for homology to antibiotic targets of DoD interest and with ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense

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