Award Data

This project seeks to develop a new broad-spectrum antiviral drug against viruses from the Bunyavirales family. These viruses have been designated as being among the highest potential to cause the next pandemic. CFD Research is advancing a natural product-derived antiviral chemistry that has demonstrated strong in vitro potency against Bunyaviruses with low cytotoxicity. We seek to produce an opti ...

Biowarfare agents pose a significant threat to military personnel and operations and effective decontamination strategies are needed to mitigate risks associated with exposure. Traditional “wet” decontamination techniques utilize harsh chemicals (e.g. bleach) and are unsuitable for sensitive equipment (e.g. communications equipment). Plasmas consisting of ionized gases, radicals and free elect ...

The goal of this proposal is it to use computational protein design to develop a set of stable, non-immunogenic enzymes for G-agent and V-agent neurotoxin deactivation based on an engineered human PON1 scaffold suitable for mass production. Chemical warfare nerve agents (CWNAs) have existed for over a century and remain a serious threat to the safety of mankind. Therapeutic enzyme treatments offer ...

Autoinjectors are a critical piece of medical countermeasure equipment for the general public and our nation’s warfighters. Autoinjectors are used to deliver injectable drugs at home or in the field. Injectable drugs are typically packaged in traditional glass primary containers that are assembled into the auto-injector. Unfortunately, the glass autoinjector containers in use today are at risk o ...

GeneCapture, Inc. is developing a novel, portable and rapid direct infection diagnostic with applications for Warfighter health and readiness. This innovative Sample-to-Answer technology can screen a human sample for many pathogens simultaneously and withstand the rigors of shipping to low resource or restricted areas. It is designed to be easy to use by available personnel. The solution is based ...

Not available

Not available

In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens, whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial and alphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable an ...

GeneCapture, Inc. is proposing to develop a rapid in vitro diagnostic prototype using our patented molecular-based CAPTURE (ConfirmActive Pathogens Through Unamplified RNA Expression) assay. Based on the results and experience gained in our Phase I STTR contractHDTRA1-16C-0061: Infectious Disease Diagnostics and Differentiation of Viral vs. Bacterial Infections for Point of Care Applications, we p ...

This project team will fully develop and test AlphaBear 2, a vocabulary learning game for grade 4 to 7 students. Vocabulary is a prerequisite for academic success, as it is linked to stronger performance across academic subjects and improved reading comprehension. It is more difficult for students to participate in educational activities without understanding the key vocabulary associated with tha ...