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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. RECAL:A New Tool for Disease Detection and Biomolecular Imaging

    SBC: Photon Biosciences LLC            Topic: 400

    Project SummaryAbstract We envision developing a new ultrasensitive detection platform that combines a recombinant protein with a unique imaging media that results in a luminescent protein that is non bleaching and non blinkingThe excitation and emission wavelengths of this protein can be tuned with the choice of imaging media and span much of the visible and near infrared regions of the electroma ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Deep Learning to Transform Clinician Autism Diagnostic Assessments and More

    SBC: Caring Technologies Inc.            Topic: 103

    NODA Telehealth system improves access to an autism diagnostic assessment by guiding families to share video clips of their child at homeso diagnostic clinicians can directly observe andtagvideo of any atypical behaviorand if warrantedrender a diagnosisThis system is evidence based and has been commercializedwith several published studies to discuss the benefitsWe now propose to improve this servi ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Real-Time Salivary Testosterone and Extension to Mobile Application and Multiple Biomarker Quantification Capability

    SBC: OASIS DIAGNOSTICS CORPORATION            Topic: NIDA

    Program Director Principal InvestigatorLastFirstMiddleSloweyPaul DAbstract This phase I NIH SBIR proposal seeks support for an interdisciplinary partnership between Oasis Diagnosticsand Iowa State University who collaboratively seek to develop a novel tool that can measure and quantify levels of the sex hormone testosterone in saliva within minutes of collectionVerOFytestosteroneThe FDA has urged ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Development of an alpha-conotoxin RgIA analog as a novel, non-opioid therapeutic for chronic neuropathic pain

    SBC: KINETA, INC.            Topic: NIDA

    PROJECT SUMMARY The objective of this SBIR Phase I application is to select an optimized lead analog ofconotoxin RgIA to develop as a uniquenon opioid therapeutic for chronic neuropathic painRgIAa peptide derived from the predatory marine cone snail Conus regiusis an inhibitor of thenicotinic acetylcholine receptornAChRa novel genetically validated pain targetOur current lead candidateKCPpotently ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. A Computer Model of Renal Physiology for use as a FDA Medical Device Development Tool

    SBC: HC Simulation, LLC            Topic: FDA

    The purpose of this proposal is to develop a validated physiological model of the human physiologyespecially the cardio renal axisfor submission to the FDA Medical Device Development Tool pilot programThe model will be used to aid in the development and regulation of medical devices designed to treat hypertensionExamples include devices for renal nerve ablationelectrical stimulation of the carotid ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. Design and Optimization of Clinical Gene Gun for Delivery of Nucleic Acid Vaccines

    SBC: Orlance, Inc.            Topic: NIAID

    Gene gun delivery of DNA vaccinesalso known as particle mediated epidermal delivery or PMEDdelivers DNA vaccines coated ontomicron sized gold particles directly into cells of the epidermisIt achieves pain free deliveryis considerably more efficient than electroporation or other DNA vaccine delivery approachesrequiresfold lower dosesand induces both systemic and mucosal responsesThe gene gun stands ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Novel peptide drug conjugates for the treatment of triple-negative breast cancers: Direct anti-tumor activity and immuno-oncology preclinical studies.

    SBC: ONCOTHERAPY SOLUTIONS LLC            Topic: 102

    ABSTRACT Triple negative breast cancersTNBCsare clinically very aggressive tumors with standard chemotherapy the only therapeutic option for patients with such cancers but the response rates are low and the prognosis remains poorPrevious published studies show that LHRH receptor is detected inof biopsy specimens from patients with TNBC and could be used for delivery of cytotoxic agentsHerewe propo ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Synthetic Universal Flu Vaccine

    SBC: TRIA BIOSCIENCE CORP.            Topic: NCIRD

    Abstract Type A and B Influenza viruses cause severe seasonal epidemics and less frequent but more deadly pandemic infectionsVaccination provides the best protectionalthough serious problems are confronting the global Influenza marketVirus diversity and mutation rates necessitate the annual production of hundreds of millions of vaccines using antiquated egg based technologiesCompounding this is th ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Development of a DCLK1 siRNA Nanoparticle as Targeted Therapy to Treat Pancreatic Cancer

    SBC: COARE Holdings, Inc            Topic: NCI

    AbstractPancreatic ductal adenocarcinomaPDACis one of the most devastating human cancersIt is the fourth leading cause of cancer related deaths in the U Sannuallywith a andltyear survival rateDespite FDA approved therapeutic regimens and marked improvements in medical and surgical careno significant impact on PDAC patient survival has been achievedInsomeAmericans are expected to be diagnosedandare ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Adherence Monitor for Substance Use Disorder Treatment

    SBC: YELLOWSTONE SCIENTIFIC INSTRUMENTS            Topic: NIDA

    Project Summary The focus of the present SBIR program is to determine the feasibility of a new noninvasivepoint of care testing device for patients undergoing treatment for substance use disorderThe new device will be capable of monitoring the progress and verifying adherence with patient treatment regimen by detecting the presenceand levelof a compounded adherence marker released in the urineprov ...

    SBIR Phase I 2018 Department of Health and Human Services

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