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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Improving the Transfer of ERK siRNA Constructs Using Nanoporous Silica

    SBC: APOLLO SRI, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Our research is focused on the potential of acid-prepared mesoporous silica (APMS) as a delivery agent for siRNA constructs to inhibit the ERK1/2 and ERK5 pathways in the treatment of human malignant mesothelioma (MM). These pathways are critical to MM cell proliferation and chemoresistance. Our initial research suggests that APMS will be significantly more eff ...

    STTR Phase I 2007 Department of Health and Human Services
  2. Development of the Pain Self-Management Program

    SBC: CONSULTANTS IN BEHAVIORAL RESEARCH            Topic: N/A

    DESCRIPTION (provided by applicant): Pain accounts for almost 80% of all of the office visits to physicians each year (National Center for Health Statistics, 1986; Stucky, Gold, & Zhang, 2001; Winterowd, Beck, & Greuner, 2003) and is a major source of disability, accounting for upwards of 700 million lost work days and $100 billion in health care costs per year (Report of the Commission on Evaluat ...

    SBIR Phase II 2007 Department of Health and Human Services
  3. Liquid Lens Array Microscope

    SBC: DMetrix, Inc            Topic: N/A

    DESCRIPTION (provided by applicant): We propose to develop a next-generation, highly flexible optical system for use in a whole- slide scanner to rapidly generate virtual slides in pathology and cytology. The primary use of this optical system is to enable ultra-rapid and accurate imaging of tissue, frozen-tissue, tissue-microarray (TMA), and cytology glass slides for clinical and research purpose ...

    SBIR Phase I 2007 Department of Health and Human Services
  4. A Global Test of Hemostatic Risk

    SBC: Haematologic Technologies, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Phase I funding for this project supported successful studies that were aimed at demonstrating the feasibility of developing an easy to use, global test in the arena of clinical hemostasis that would be sensitive to antithrombotic drugs, bleeding disorders and thrombotic pathologies. This test comprises a measurement of the rate of thrombin generation and/or to ...

    STTR Phase II 2007 Department of Health and Human Services
  5. Whole Genome qNPA Gene Expression Platform

    SBC: HIGH THROUGHPUT GENOMICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The identification of gene targets for drug discovery, including AIDS research and mental health, relies heavily on the use of high density array whole genome platforms. It is also true for the discovery of biomarkers for diagnostic assays. The quantitative reliability and reproducibility of data from such platforms is low, requiring both extensive validati ...

    SBIR Phase I 2007 Department of Health and Human Services
  6. Reducing noise of mammographic LCD Displays

    SBC: IMAGE QUALITY, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): This SBIR Phase I proposal addresses the problem of image quality degradation due to noise of Active Matrix Liquid Crystal Displays (AMLCD), which are increasingly used as primary diagnostic softcopy display in clinical medicine, especially for mammography. The primary goal of this proposal is to explore the properties of LCD noise and to develop a reliable and ...

    SBIR Phase I 2007 Department of Health and Human Services
  7. Targeted Blood Brain Barrier Permeability Changes with Ultrasound & Microbubbles

    SBC: IMARX THERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Ultrasound mediated destruction (UMD) of intravenously injected microbubbles has the potential to alter blood brain barrier (BBB) permeability at selective locations within the central nervous system. This selective alteration in BBB permeability could have significant therapeutic potential in targeting drug delivery for primary or metastatic central nervous sy ...

    STTR Phase I 2007 Department of Health and Human Services
  8. MS based approaches for diabetes biomarker discovery

    SBC: INTRINSIC BIOPROBES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The objective of this proposal is to apply novel affinity mass spectrometry (AMS) technologies to identify protein biomarkers for pre-diabetes or type 2 diabetes. The methodology used combines micro-affinity protein capture from complex biological solutions with mass spectrometric detection. In this first phase (R21), we will screen the provided plasma and bloo ...

    STTR Phase II 2007 Department of Health and Human Services
  9. E-learning for HAZMAT and Emergency Response

    SBC: Inxsol LLC            Topic: N/A

    DESCRIPTION (provided by applicant) inXsol LLC will undertake research to establish the technical/scientific merit and feasibility for the design and use of an affordable, stand alone simulation-based training tool to supplement instructor guided training for hazardous materials health and safety that can be tailored to meet the local needs of cities and states. The research will exa ...

    SBIR Phase I 2007 Department of Health and Human Services
  10. Theory of Mind Software for Autism and other Communication Disorders

    SBC: LAUREATE LEARNING SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Full participation in the human social milieu requires that one be able to understand that other people have their own goals, intentions, and beliefs (which may or may not be correct) - and that these epistemic states govern people's behavior. This form of awareness has been called Theory of Mind (ToM). Unfortunately, the development of ToM is severely delayed ...

    SBIR Phase I 2007 Department of Health and Human Services

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