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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Improving the Transfer of ERK siRNA Constructs Using Nanoporous Silica

    SBC: APOLLO SRI, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Our research is focused on the potential of acid-prepared mesoporous silica (APMS) as a delivery agent for siRNA constructs to inhibit the ERK1/2 and ERK5 pathways in the treatment of human malignant mesothelioma (MM). These pathways are critical to MM cell proliferation and chemoresistance. Our initial research suggests that APMS will be significantly more eff ...

    STTR Phase I 2007 Department of Health and Human Services
  2. A Global Test of Hemostatic Risk

    SBC: Haematologic Technologies, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Phase I funding for this project supported successful studies that were aimed at demonstrating the feasibility of developing an easy to use, global test in the arena of clinical hemostasis that would be sensitive to antithrombotic drugs, bleeding disorders and thrombotic pathologies. This test comprises a measurement of the rate of thrombin generation and/or to ...

    STTR Phase II 2007 Department of Health and Human Services
  3. Theory of Mind Software for Autism and other Communication Disorders


    DESCRIPTION (provided by applicant): Full participation in the human social milieu requires that one be able to understand that other people have their own goals, intentions, and beliefs (which may or may not be correct) - and that these epistemic states govern people's behavior. This form of awareness has been called Theory of Mind (ToM). Unfortunately, the development of ToM is severely delayed ...

    SBIR Phase I 2007 Department of Health and Human Services
  4. 3D Virtual Slide System for Creation and Analysis of Focusable Digital Slides

    SBC: MICROBRIGHTFIELD, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Rigorous quantification methods of histological specimens have become a keystone in modern neuroscience such as investigations of neurogenesis, stem cell research, neurotransplantation, neurotoxicology, and the pathogenesis of neurodegenerative and neuropsychiatric diseases. Methods in current practice are not conducive to high-throughput studies because they a ...

    SBIR Phase II 2007 Department of Health and Human Services
  5. Integrated Teleconferencing Unit For Home-Based Interactive Exercise For Elders


    DESCRIPTION (provided by applicant): Supervised group exercise has been shown to be an effective component for improving balance and preventing falls among elders who have suffered falls or exhibit a fear of falling due to frailty. In a Phase I SBIR study, we developed a model for conducting group exercise programs for elders in their homes via video- conferencing, called tele-based group exercise ...

    SBIR Phase II 2007 Department of Health and Human Services
  6. Automated Connective Tissue Torque Sensor

    SBC: STROMATEC, INC            Topic: N/A

    DESCRIPTION (provided by applicant): The long term goal of this project is to establish the usefulness of needle torque measurements for the diagnosis and monitoring of connective tissue pathology associated with chronic musculoskeletal conditions treated by manual therapies. This project will combine technologies developed in our previous research and technological transfer programs which 1) show ...

    SBIR Phase I 2007 Department of Health and Human Services
  7. Head orientation sensing system

    SBC: APPAREO SYSTEMS LLC            Topic: AF071020

    Appareo Systems, LLC, proposes to develop a functional prototype head-mounted position and orientation system (HPOS). The HPOS will be capable of operating in electromagnetic fields of up to 200 volts/meter and will provide at least one degree of accuracy and at least one degree of resolution at a 60 Hz update rate while providing 3 degree of freedom (DOF) information on head orientation, includi ...

    SBIR Phase I 2007 Department of DefenseAir Force
  8. Advanced Detection of Improvised Explosive Devices (IEDs)

    SBC: QuantaSpec Inc.            Topic: AF06113

    Standoff detectors are required to detect IEDs. These detectectors are needed to save the lives of American soldiers. QuantaSpec has developed patent pending methods for long-range, sensitive, and selective standoff detection of explosives. These methods have already demonstrated sensitive remote detection of explosive vapors under previous efforts. QuantaSpec's multidisciplinary team will dem ...

    SBIR Phase II 2007 Department of DefenseAir Force
  9. High Energy Density, Low-Cost, High Temperature Capacitors for Hybrid Vehicles

    SBC: Sbe Inc            Topic: 05

    Hybrid Electric Vehicles (HEVs) and plug-in Hybrid Vehicles (PHEVs) require advanced technology capacitors, which must have low cost and the ability to operate at 150oC. However, current 150oC film capacitor solutions are expensive and have lower energy density compared to materials that operate at lower temperatures. Polypropylene Film Capacitors represent a potentially cost effective solution ...

    SBIR Phase I 2007 Department of Energy
  10. A New High-Resolution Method for the Characterization of Heterogeneous Subsurface Environments: Providing Flow and Transport Parameters via the Integration of MultiScale HydroGeophysical Data

    SBC: New England Research, Inc.            Topic: 49

    Historically, remediation efforts at DOE contaminated sites have relied on numerical models to integrate laboratory and field characterization data, predict the fate and transport behavior of contaminant plumes, design remediation protocols to mitigate contaminant migration, and analyze data from field remediation results. Of particular concern is the effect of subsurface heterogeneities and thei ...

    SBIR Phase I 2007 Department of Energy

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