Award Data

78365 Free-surface, flowing, liquid-metal cooling systems are an option for the removal of heat from energy-producing fusion devices. However, these free flowing liquid films are difficult to direct and contain because of their interactions with the high energy plasma and the powerful magnetic fields present in these machines. This project will develop a, capillary assisted, thin flowing, lithi ...

75554B Fuel cells are an efficient, combustion-less, virtually pollution-free source of power. In particular, Proton Exchange Membrane (PEM) fuel cells are ideal for a number of applications, due to their ¿quick¿ warm-up characteristics. However, these fuel cells contain some inherent inefficiencies, which results in waste heat that must be removed rapidly via a coolant ¿ currently, either D ...

DESCRIPTION (provided by applicant): Advaxis will develop a novel Listeria monocytogenes based vaccine against the human HER-2/neu protein that will be a safe and effective therapeutic vaccine for the treatment of HER-2/neu overexpressing breast carcinomas. Breast cancer, the most common type of cancer in women, is a complex disease with no single causative agent or event. There are several tumor- ...

DESCRIPTION (provided by applicant): The long-term goal of this program is to identify and develop novel inhibitors of human sphingosine kinase (SK) that are effective as therapeutic agents. Because of its critical role in sphingolipid metabolism and angiogenesis, we have focused on SK as an innovative molecular target for the development of new drugs for the treatment of diabetic retinopathy. Sph ...

DESCRIPTION (provided by applicant): The long-term goal of this program is to develop novel inhibitors of human sphingosine kinase (SK) that are effective as therapeutic agents. Because of its critical role in sphingolipid metabolism, we have focused on SK as an innovative molecular target for the development of new drugs for the treatment of Inflammatory Bowel Diseases (IBDs). Sphingolipids are b ...

DESCRIPTION (provided by applicant): The long-term goal of this program is to develop novel inhibitors of human sphingosine kinase (SK) that are effective for the treatment of arthritis. Sphingolipids are being increasingly recognized as key mediators of apoptosis, stress responses, cell differentiation and proliferation, and are known to regulate the inflammatory cascade of central importance in ...

DESCRIPTION (provided by applicant): Acid-prepared mesoporous silica ("APMS") shows significant advances over commercially available silica in high performance liquid chromatography ("HPLC"), a technique commonly used to isolate molecules. HPLC columns containing APMS show dramatically enhanced molecular retention times and improved peak-to-peak resolutions compared to commercial HPLC columns. The ...

79139S In power electronic conversion systems(PCS), wide band gap devices, such as silicon carbide (SiC), offer the promise of vastly exceeding the constraining restrictions of silicon by offering higher blocking voltages, higher operating temperatures, higher frequency, and lower switching losses compared to other, more conventional devices. These performance increases all directly translate to ...

DESCRIPTION (provided by applicant): The overall objective of the proposed cooperative research and development project is the implementation and validation of an advanced instrument tracking technology to be used by the surgeon, the radiologist, the gastroenterologist, and other physicians to better enable image-guided cancer treatment, through these specific aims: Specific aim 1: Ascension ...

DESCRIPTION (provided by applicant): To address wayfinding difficulties and physical activity among cognitively-impaired older adults, we propose to develop a navigation aid that can be attached to three- and four-wheeled rollators. The navigation aid will provide navigation assistance to the user and will track the user's movements for later analysis by caregivers. Navigation assistance will be p ...