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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Reduction of Dietary Oxalate

    SBC: CAPTOZYME LLC            Topic: NCCAM

    DESCRIPTION (provided by applicant): Kidney stones are a common and painful human health care problem worldwide. Of all stones developed approximately 75% are composed of calcium oxalate. Urinary oxalate is regarded as a driving force for calcium oxalate stone formation, and absorption of dietary oxalate contributes to 10-70% of urinary oxalate. In fact, roughly 2.4 million Americans (0.75% of the ...

    SBIR Phase II 2012 Department of Health and Human Services
  2. Connective Tissue Motion Measure 2

    SBC: STROMATEC, INC            Topic: NCCAM

    DESCRIPTION (provided by applicant): Connective tissue dysfunction is emerging as a potentially important, and so far mostly overlooked, factor in the pathophysiology of chronic low back pain (LBP). We have developed and tested a novel instrument (StromaGlide) and test (Connective Tissue Motion Measure - CTMM) -quantifying the functional behavior of perimuscular connective tissues. The results of ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. Development of Wnt Pathway Inhibitors for Colorectal Cancer

    SBC: Stemsynergy Therapeutic            Topic: NCI

    DESCRIPTION (provided by applicant): StemSynergy Therapeutics Inc. (SSTI) is a biopharmaceutical company focused on the discovery, development, and commercialization of drugs that target pathways fundamental to stem cells and cancer stem cells. The WorldHealth Organization estimates that over 12 million cases of cancer were diagnosed in 2007 and that nearly 8 million cancer patients will die of t ...

    SBIR Phase II 2012 Department of Health and Human Services
  4. Software to Enrich the Noun Lexicons and Lexical Learning of Children with Autism

    SBC: LAUREATE LEARNING SYSTEMS, INC.            Topic: NIDCD

    DESCRIPTION (provided by applicant): The objective of this project is to develop and field-test prototype software for a research-based vocabulary development program featuring a combined lexical-cognitive approach to noun acquisition. The target population for the curriculum will be 3-8 year old children with Autism Spectrum Disorders (ASD), as well as a broad range of other children with languag ...

    SBIR Phase II 2012 Department of Health and Human Services
  5. Quick-Set Material-Phase II

    SBC: PRIMUS CONSULTING            Topic: NIDCR

    DESCRIPTION (provided by applicant): Quick-Set Material- Phase II Quick-Set material is proposed for vital pulp therapy and for non-vital endodontic use to make the clinical procedures shorter and more consistent, of benefit to the patient and clinician,and enhance the probability for a positive outcome. The new material should promote regeneration of the periodontal ligament and cemental tissues ...

    SBIR Phase II 2012 Department of Health and Human Services
  6. A perfluorocarbon-based culture device for beta cell biology applications (Phase

    SBC: Ophysio Inc.            Topic: NIDDK

    ABSTRACT Conventional culture vessels are not designed for physiological oxygen delivery. Both hyperoxia and hypoxia - commonly observed when culturing cells and tissues in regular plasticware- have been linked to reduced cellular function and death. An adequate means to provide oxygenation is also critical for stem cell applications in which the differentiation outcome is dependent on oxygen ten ...

    SBIR Phase II 2012 Department of Health and Human Services
  7. Safety and Efficacy of Single-use Cliradex Pads for Ocular Mites

    SBC: TISSUETECH, INC.            Topic: NEI

    DESCRIPTION (provided by applicant): Demodex mites are microscopic ectoparasites that commonly infest the pilosebaceous unit of the skin. Uncontrolled overgrowth of mites has been implicated in causing papulopustular lesions in the skin, rosacea in the face, and blepharitis in the eye. Blepharitis (lid margin inflammation) associated with mite-harboring cylindrical dandruff in eyelashes is one of ...

    SBIR Phase II 2012 Department of Health and Human Services
  8. Amniotic Membrane versus Pericardium in Reducing Glaucoma Drainage Tube Exposure

    SBC: TISSUETECH, INC.            Topic: NEI

    DESCRIPTION (provided by applicant): Glaucoma drainage devices (GDDs) have widely been used in the treatment of high-risk refractory glaucoma. To avoid tube exposure, which may lead to serious eye infection, the implanted GDD tube must be covered by apatch graft traditionally made of either donor sclera or pericardium. However, these patch grafts still carry a high rate of progressive thinning ...

    SBIR Phase II 2012 Department of Health and Human Services
  9. Virtual Emergency Medical Technician-Basic Training Program

    SBC: ARCHIE MD INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): ZetrOZ has developed a prototype novel, miniature, portable, high-power, ultrasound system for would healing. Wound healing is a major clinical issue, and can present significant clinical challenges both when wounds areacute--occurring due to trauma, burns, surgery, or due to more chronic health problems. Wound healing is an intricate fibroproliferative respons ...

    SBIR Phase II 2012 Department of Health and Human Services
  10. System for multidimensional analysis of growth and migration of neurons and neuro

    SBC: MICROBRIGHTFIELD, INC.            Topic: NIMH

    DESCRIPTION (provided by applicant): This project aims at developing the Orion microscope system, a highly innovative combined software/hardware product, which will facilitate automated investigations of dynamics of migration of neuronal precursors and neurite outgrowth in vitro using time-lapse video-microscopy (TLVM). To achieve this goal, the Orion microscope system will combine novel software ...

    SBIR Phase II 2012 Department of Health and Human Services

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