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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Oral transmucosal drug delivery system for naltrexone

    SBC: BIONEX PHARMACEUTICALS LLC            Topic: NIAAA

    DESCRIPTION (provided by applicant): The proposed SBIR Phase II project aims at developing a new drug product, the naltrexone orally dissolving film (ODF), for treatment of alcohol dependence. The naltrexone ODF is a small, thin, and flexible film, containing naltrexone hydrochloride and other excipients. It is applied intra-orally and adheres to the oral mucosa to affect a rapid onset of action d ...

    SBIR Phase II 2012 Department of Health and Human Services
  2. Effect of ScanCap Technology on Medication Adherence and Hypertension Outcomes

    SBC: Concordance Health Solutions, Inc.            Topic: NIA

    DESCRIPTION (provided by applicant): In this Phase II SBIR project, Concordance Health Solutions (CHS) will continue development of the ScanCap System and test its effectiveness on adherence rates and hypertension patient outcomes The ScanCap System is anelectronic reminder cap that is seamlessly programmed at the pharmacy and incorporated into original packaging for prescription medications. The ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. Arm Motor Rehabilitation, Entertainment and Cognition System for the Elderly

    SBC: Bright Cloud International Corp            Topic: NIA

    DESCRIPTION (provided by applicant): It is hypothesized that the use robotic rehabilitation tables coupled with virtual reality games with elderly stroke survivors residents in skilled nursin facilities (SNFs) will: 1) improve and maintain upper extremityuni-manual and bimanual function, reach, strength and ADL independence; 2) improve and maintain cognition (memory, focus, problem solving); and ...

    SBIR Phase II 2012 Department of Health and Human Services
  4. Protein Therapeutics for Muscular Dystrophy

    SBC: TRIM-EDICINE, INC.            Topic: NIAMS

    DESCRIPTION (provided by applicant): SBIR 1R43AR060019 Phase II application: Protein Therapeutics for Muscular Dystrophy Principal Investigator: Takizawa, Norio Project Summary: This application requests for a Phase II project for our initial SBIR grant addressing the use of a novel protein therapeutic agent, MG53, for the treatment of muscular dystrophy (1R43AR060019). Our Phase I studi ...

    SBIR Phase II 2012 Department of Health and Human Services
  5. Connective Tissue Motion Measure 2

    SBC: STROMATEC, INC            Topic: NCCAM

    DESCRIPTION (provided by applicant): Connective tissue dysfunction is emerging as a potentially important, and so far mostly overlooked, factor in the pathophysiology of chronic low back pain (LBP). We have developed and tested a novel instrument (StromaGlide) and test (Connective Tissue Motion Measure - CTMM) -quantifying the functional behavior of perimuscular connective tissues. The results of ...

    SBIR Phase II 2012 Department of Health and Human Services
  6. Software to Enrich the Noun Lexicons and Lexical Learning of Children with Autism

    SBC: LAUREATE LEARNING SYSTEMS, INC.            Topic: NIDCD

    DESCRIPTION (provided by applicant): The objective of this project is to develop and field-test prototype software for a research-based vocabulary development program featuring a combined lexical-cognitive approach to noun acquisition. The target population for the curriculum will be 3-8 year old children with Autism Spectrum Disorders (ASD), as well as a broad range of other children with languag ...

    SBIR Phase II 2012 Department of Health and Human Services
  7. Off-the-shelf Dental Regeneration Technologies

    SBC: INNOVATIVE ELEMENTS, LLC            Topic: NIDCR

    DESCRIPTION (provided by applicant): Dentin forms the bulk of the tooth and is covered by enamel in the crown of the tooth and cementum in the root. When dental caries breaks down enamel and involves the dentin, the patient experiences pain and thermal sensitivity. The acute phase of dental pulp infection is typically associated with excruciating pain, and if not properly managed, can lead to per ...

    SBIR Phase II 2012 Department of Health and Human Services
  8. Obese diabetic (type II) mouse model without leptin/leptin-receptor defects

    SBC: PRECLINOMICS, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): An estimated 23.6 million people (7 percent of the population) in the United States have diabetes; 90 to 95 percent of all diagnosed cases are type 2 diabetes (CDC, 2007). Obesity and metabolic syndrome are the leadingcauses of type 2 diabetes. The search for new and more effective therapies to address the growing number of Americans with type 2 diabetes and re ...

    SBIR Phase II 2012 Department of Health and Human Services
  9. Enabling Technology to Prepare Ultrapure Dialysate in Dialysis Clinics

    SBC: NOVAFLUX TECHNOLOGIES, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): The clinical significance of chronic pro-inflammatory reactions in dialysis patients due to exposure to endotoxin has become a central issue in nephrology. The European Renal Association urges the routine use of ultrapure dialysate with bacteria and endotoxin levels of lt 0.1 CFU/ml and lt 0.03 EU/ml, respectively. In the US, the maximum allowable limit of ba ...

    SBIR Phase II 2012 Department of Health and Human Services
  10. Point-of Care System for Determination of Bilirubin Capacity in Neonates

    SBC: AVIV BIOMEDICAL INC            Topic: NIBIB

    DESCRIPTION (provided by applicant): Uncontrolled hyperbilirubinemia (jaundice) in neonates has long been known to lead to neurological dysfunction including irreversible athetoid cerebral palsy with speech, ocular and hearing impairments, and even death.Contemporary management is based upon monitoring the total serum bilirubin (TBS), taking into account other clinical parameters such as birth wei ...

    SBIR Phase II 2012 Department of Health and Human Services

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