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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Inhibitors of Mycobacterial Protein Tyrosine Phosphatase B (mPTPB) for therapy of

    SBC: AARDEN PHARMACEUTICALS, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Inhibitors of Mycobacterial Protein Tyrosine Phosphatase B (mPTPB) for therapy of tuberculosis Aarden Pharmaceuticals Project Summary/Abstract The need exists for a new, breakthrough therapeutic for tuberculosis (TB). Current treatment regimens with toxic chemotherapeutic drugs are too long, causing poor compliance which results in reduced efficacy and the emer ...

    STTR Phase I 2013 Department of Health and Human Services
  2. Proteomic differentiation of leukemia cells based on multiplexed arrays and mass

    SBC: Tymora Analytical Operations, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Although some gene mutations can predict response to certain targeted therapies, single-gene testing has limits. Multiple important signaling pathways that may be the causes of human malignancy have continuously been discovered and dissected. Pathway and network diagnostic tests are challenging but are clearly on the way. Through this NIH STTR Phase I study, we ...

    STTR Phase I 2013 Department of Health and Human Services
  3. Novel VLP Adjuvant based on the VesiVax system

    SBC: Euclid Diagnostics LLC            Topic: NCI

    DESCRIPTION (provided by applicant): Over one million prostate biopsies are performed in the US each year to diagnose approximately 200,000 cases of prostate cancer. The majority of these biopsies are performed needlessly. The overall objective of this project is to develop a secondary prostate cancer diagnostic test that can be performed on men with elevated PSA in order to identify patients in n ...

    SBIR Phase I 2013 Department of Health and Human Services
  4. NIEHS- Device Agnostic Environmental/Agent Data Collection and Integration with

    SBC: APEX Therapeuitcs, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): Our long-term goal is to develop a novel therapeutic strategy for childhood acute lymphoblastic leukemia (ALL), with focus on relapsed T-cell leukemia. We intend to accomplish this by targeting a unique molecular masterregulator using a new generation of compounds. ALL is the most frequent cancer of the childhood. Although significant progress has been achieved ...

    SBIR Phase I 2013 Department of Health and Human Services
  5. Identification and Validation of Targets of Phenotypic High Throughput Screening

    SBC: Prosolia, Inc.            Topic: NIGMS

    DESCRIPTION: Development of an Intelligent Sample Introduction System for Mass Spectrometry There is a pressing need for new technologies that enable rapid measurements without significant compromise to the analytical data. Herein, we propose to develop arobust mass spectrometry (MS) based surface sampling device that enables direct analysis of a variety of materials including biological tissue a ...

    SBIR Phase I 2013 Department of Health and Human Services
  6. Multi-Functional Guidewire for Peripheral Vasculature

    SBC: 3dt Holdings, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Over 8 million Americans have peripheral vascular disease (PAD). Percutaneous transluminal artery (PTA) treatment of severe PAD involves the use of balloons and stents, but delivery of these therapies is often suboptimal due to inaccuracies in angiographic assessment of vessel size or a lack of proper functional vessel assessment. Additional tools aid clinician ...

    SBIR Phase I 2013 Department of Health and Human Services
  7. Portable device for monitoring water balance in elderly

    SBC: 3dt Holdings, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Transseptal (TS) access for left heart procedures is an important and rapidly growing space for diagnostics and therapy delivery with an expected total of over 10 million U.S. patients. In the U.S. and/or Europe, TS access procedures are used for atrial fibrillation (AF) ablation, left atrial appendage (LAA) closure, patent foramen ovale (PFO) closure, and trea ...

    SBIR Phase I 2013 Department of Health and Human Services
  8. A mechanism-based computational tool to optimize pulmonary drug delivery

    SBC: 3dt Holdings, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Coronary artery disease (CAD) is a national and worldwide epidemic that places the largest clinical and economic burden on the healthcare system of any disease condition. Patients with stable and acute coronary conditions are often treated with percutaneous coronary intervention (PCI), including stenting. Up to 85% of all coronary stents are under-deployed lead ...

    SBIR Phase I 2013 Department of Health and Human Services
  9. Bioartificial Brain Slices for Drug Screening

    SBC: MICROBRIGHTFIELD, INC.            Topic: NIMH

    DESCRIPTION (provided by applicant): It has become evident that the microvasculature (i.e., the vasculature visible at the light microscopic level) plays a critical role in the plasticity of he brain under various physiological and pathological conditions,including fundamental processes in neuroplasticity such as axonal, dendritic and synaptic plasticity during brain development, learning, recover ...

    SBIR Phase I 2013 Department of Health and Human Services
  10. A national screening test for hearing, administered by telephone.

    SBC: COMMUNICATION DISORDERS TECHNOLOGY, INC            Topic: NIDCD

    DESCRIPTION (provided by applicant): An estimated 36 million US citizens have impaired hearing, but only one in five has had a hearing test. As noted by a recent NIDCD Working Group, In the US there are no readily accessible low-cost hearing screening programs. The authors of this proposal, in collaboration with scientists from Indiana University and VU University Medical Center of Amsterdam, ha ...

    SBIR Phase II 2013 Department of Health and Human Services

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