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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Compact sheath-flow-free multichannel flow cytometer

    SBC: Adeptas, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Flow cytometers are valuable tools for the rapid analysis of cells and macromolecules for both research and diagnostic purposes. Ideally, flow cytometry based analysis could benefit more researchers and clinicians if the units were more affordable, smaller, and even portable. New fabrication techniques and design approaches developed in the microfluidics and la ...

    SBIR Phase I 2005 Department of Health and Human Services
  2. Multi-frequency impedance sensor for cell analysis

    SBC: Adeptas, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Broadband impedance analysis of individual cells yields a wealth of information about cell size, viability, morphology and interior structure. Cell dielectric properties including membrane conductivity, cytoplasmic conductivity, and membrane capacitance can be derived from multi-frequency impedance data and used to differentiate and enumerate cell populations i ...

    SBIR Phase I 2005 Department of Health and Human Services
  3. Low Cost Automated Urinalysis using Spectral Data

    SBC: Advanced Digital Imaging Research, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Clinical urinalysis is performed to examine the chemical and formed particle composition of urine. It is used as a screening and/or diagnostic tool to detect different metabolic and kidney disorders, urinary tract infections, diabetes and pregnancy. Routine urinalysis consists of a physical (color, clarity, odor), chemical (protein, glucose, nitrites, etc.), an ...

    SBIR Phase I 2005 Department of Health and Human Services
  4. Phase II Clinical Trial of Lactoferrin in Asthma

    SBC: AGENNIX, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The purpose of this research is to determine the efficacy of orally administered recombinant human lactoferrin (rhLF) in Phase II clinical trials in patients with mild to moderate asthma. Asthma is one of the most prevalent chronic inflammatory diseases in the United States affecting approximately 15 percent of the population. Despite intensive research on as ...

    SBIR Phase II 2005 Department of Health and Human Services
  5. Antimicrobial & Immunization for Bacterial Gastritis

    SBC: Amarillo Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Helicobacter pylori (Hp), a gastric bacterial pathogen of humans; infection is the cause of type B gastritis and is also strongly associated with gastric carcinoma (intestinal type) and gastric MALT lymphoma. Combination antimicrobial therapy (triple therapy with a bismuth salt, metranidazole and a broad spectrum antibiotic) is successful in 80% of Hp-infected ...

    SBIR Phase I 2005 Department of Health and Human Services
  6. Ultra Rapid Methods for Streamlined Tissue-to-RT-PCR

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This Phase II proposal aims to simplify, expedite, and stabilize the recovery of high quality RNA from tissue samples. In Phase I, we demonstrated the feasibility of a hands-off, closed tube tissue disruption method termed "MELT" (Multi-Enzymatic Liquefaction of Tissue). MELT enlists potent catabolic enzymes to liquefy tissue within minutes without invasive ...

    SBIR Phase II 2005 Department of Health and Human Services
  7. Cost-Effective Manufacturing of Pharmaceutical mRNA

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The overall objective of this proposal is to develop methods for the cost-effective, large-scale synthesis (up to kilograms amounts) of capped, polyadenylated RNA. Several companies are using capped RNA to produce human vaccines against cancers and infectious diseases such as HIV and biowarfare agents. Ambion's patented mMESSAGEmMACHINE(r) kit provides high- ...

    SBIR Phase II 2005 Department of Health and Human Services
  8. Enabling RNA Analyses from Formaldehyde-fixed Tissues

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term objectives of this proposal are to permit the isolation of RNA from fixed and imbedded tissues for gene expression analysis. The widespread use of tissue fixation and embedding in both clinical and research settings has resulted in the accumulation of large stores of fixed and embedded tissues in medical schools, hospitals, and universities. The ...

    SBIR Phase II 2005 Department of Health and Human Services
  9. Bead-array for rapid risk-stratification in leukemia

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Accurate differentiation of fusion transcripts derived from chromosome translocations is of critical importance for optimizing treatment strategies for leukemia. However, as the number of leukemia associated translocations is steadily increasing, single-tube, multiplex detection of multiple fusion gene transcripts becomes challenging. The overall goal of this p ...

    SBIR Phase I 2005 Department of Health and Human Services
  10. Sensitive expression profiling in fixed archived tissue

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Archives of formalin-fixed paraffin embedded (FFPE) human histological tissue samples, probably numbering in the millions of tissue blocks, constitute a tremendous, yet underutilized, historical resource for studying gene expression changes associated with human disease states. Unlike freshly acquired samples, there is usually greater documented medical hist ...

    SBIR Phase I 2005 Department of Health and Human Services

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