Award Data

DESCRIPTION (provided by applicant): Influenza is characterized by recurrent annual epidemics and periodic major worldwide pandemics. Because of the high disease-related morbidity and mortality, direct and indirect socio-economic impacts of influenza are enormous. In the last 100 years, there have been 3 major influenza pandemics. It has been about thirty years since the last pandemic. A new pand ...

Microcosm, Inc. is proposing to complete the buildup of the suborbital rocket (SR-M) vehicle and launch this vehicle within twelve months of the authority to proceed. The suborbital rocket SR-M can carry up to a 2,400 pound payload. The SR-M offers considerable flexibility and performance while achieving low mission cost. Variations of the vehicle can be created to form the core of various mission ...

Efficient structures requiring low-volume and low-mass have an important role in future military and commercial missions especially in theatre of space. These structures can increase the peformance of applications requiring large apertures such as space-based intelligence, surveillance, and reconnasissance systems. These structures can also be efficient as inflatable, deployable target simulator ...

Hardware- and software-in-the-loop models offer an efficient and scalable approach for analysis of distributed C4ISR applications executing on heterogeneous networks. A virtual laboratory that integrates a physical test-bed with a much larger simulated network, can incorporate realistic physical effects while simultaneously scaling the analysis to much larger networks than are physically accessi ...

DESCRIPTION (provided by applicant): Vical Inc. of San Diego, Ca. is the largest GMP manufacturer of plasmid DNA for vaccine clinical trials in the world. We have manufactured GMP plasmid DNA vaccines that are being used or entering clinical trials for HIV (in the US and China), malaria (up to 9 plasmids), Ebola, WNV, and SARS. Vical has undertaken an internal Product Development Program that focu ...

DESCRIPTION (provided by applicant): The goal of this study is to identify the genetic determinants of late-onset Alzheimer's disease (AD). The proposed study uses Perlegen Sciences' high-density oligonucleotide array-based genotyping platform to genotype over 1.5 million single nucleotide polymorphisms (SNPs) across the genome in the context of a whole-genome association study of late-onset AD. ...

DESCRIPTION (provided by applicant): Treatment and prevention of hepatitis C virus (HCV) infections remains a major challenge for controlling this worldwide health problem; existing therapies are only partially effective and no vaccine is currently available. RNA interference offers the potential of a novel therapeutic approach for treating HCV infections. Toward this end, we are developing small ...

The objective of this proposal is to develop a preliminary brassboard implementation for an H-60 system and for the AN/ALE-47, and demonstrate the interfaces through simulated flight using the ADVAYK brassboard. All designs will be virtually simulated and validated to ensure the desired behavior of the existing system is captured. The designs for each of the three projects will be validated vir ...

DESCRIPTION (provided by applicant): Stroke is the 3rd leading cause of death in the U.S. and is also a leading cause of severe, long-term disability. The total cost of stroke to the United States is estimated at about $43 billion per year. The only FDA-approved treatment for acute ischemic stroke is recombinant tissue plasminogen activator (rt- PA). However, the therapeutic window of rt-PA is on ...

DESCRIPTION (provided by applicant): Infection with the human immunodeficiency virus (HIV) has led to one of the most costly and devastating epidemics of the last two decades. Untreated, the virus slowly destroys the immune system, leading to significant morbidity and virtually 100% mortality within two to twenty years after initial infection. Fortunately, recent advances in antiretroviral therap ...